Download Pharmacy Curriculum Draft (NCRC); 2011
Download Pharmacy Curriculum Draft (NCRC); 2011 Download Pharmacy Curriculum Draft (NCRC); 2011
a. Two compartment open model.b. IV bolus, IV infusion and oral administrationIII. Non-compartmental Model.Statistical Moment Theory; MRT for various compartment models;Physiological Pharmacokinetic model.PHARM 617 PHARMACEUTICS-VIII (Biopharmaceutics-I) [Lab.]Cr. Hr.: 01 Marks: 50NOTE:- Practical of the subject shall be designed from time to time on the basis ofthe above mentioned theoretical topics and availability of the facilities,e.g. Blood Sampling Techniques (In Laboratory Animals like dog,rabbits, mice etc. in human beings), In-vitro dissolution studies, Optionaldose determination, Measurement of rate of Bioavailability,Determination of relative and absolute bioavailability. Plasma level-timecurve (Determination of Pharmacokinetic parameters). Determination ofplasma protein binding. Urinary sampling techniques. In Laboratoryanimals. In humans. Renal excretion of drugs or drug disposition.Recommended Books:1. Leon Shargel, Applied Pharmacokinetics and Biopharmaceutics,Appleton & Lange, New York, 5th Ed., 2008.2. Malcoln Rouland, Thomous N Tozer, Clinical Pharmacokinetics, William& Willkins, London, 1995.3. Milo Gibaldi, Biopharmaceutics and Clinical Pharmacokinetics, 4 thEd,Marchel& Dakker Inc, New York, 2008.4. Gibbson and Skett, Introduction to Drug Metabolism, 3 rd Ed,Champ &Hall, London, 2001.5. Robert E Notari, Biopharmaceutics and Clinical Pharmacokinetics, 4 th Ed,Marchel & Dakker Inc, New York, 1988.6. Sarfraz Niazi, Text Book of Biopharmaceutics & ClinicalPharmacokinetics. Appleton-Century-Crofts, New York, 1985.7. Gul Majid Khan,Biopharmaceutics: Text Book for Pharmacy Students &Working Pharmacists[ISBN978-969-9101-00-7]8. Gul Majid Khan,Text Book of Biopharmaceutics & Pharmacokinetics forPost Graduate Students9. Gul Majid Khan,Laboratory Manual of Biopharmaceutics&Pharmacokinetics[ISBN 978-969-9101-02-1]10. Stephen H Curry, Drug disposition and pharmacokinetics, Black WellScientific Publishing, Oxford, 1983.11. Avraham Yacobi, Toxicokinetics and New Drug Development, ParamountPress, New York, 1989.12. P Macheras, C Reppas and J B Dressman, Biopharmaceutics of orallyadministered drugs, Ellis Horwood Limited, London (1995).13. Albert P Li, In vitro approaches for evaluation of drug efficacy andtoxicity, CRC Press LLC USA, 2004.70 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
14. Ronald D Schoenwald, Pharmacokinetics in drug discovery andDevelopment, CRC Press LLC, USA, 2002.PHARM 618 PHARMACEUTICS-IX (Pharmaceutical QualityManagement-I) [Th.]Cr. Hr.: 03 Marks: 1001. INTRODUCTION:(a) Basic concepts about introduction of pharmaceutical industry inrelevance to quality assurance and quality control departments, testing,quality management system, quality assurance, quality control,Standard.(b) General understanding of good laboratory practices and validation2. QUALITY CONTROL OF SOLID DOSAGE FORMS:(a) Physical tests: Hardness, Thickness and Diameter, Friability,Disintegration, Weight Variation.(b)Chemical tests: Content uniformity, Assay of active ingredients anddissolution tests of Powders, Granules, Tablets and Capsules.3. QUALITY CONTROL OF SYRUPS AND ELIXIRS:Viscosity, itsdetermination and application in the Quality Control of Pharmaceuticals,Weight per ml and Assay of active ingredients.4. QUALITY CONTROL OF SUPPOSITORIES: Disintegration test,Uniformity of weight, Assay of active ingredients, Liquefaction time test andBreaking test.5. QUALITY CONTROL OF STERILE PRODUCTS(PARENTERALS):Sterility Test and Sterile section management, Leaker’stest, Clarity test, Pyrogen test for Parenteral and other sterile preparations,Assay for active ingredients.PHARM 619 PHARMACEUTICS-IX (Pharmaceutical QualityManagement-I) [Lab.]Cr. Hr.: 01 Marks: 50NOTE:-Practical of the subject shall be designed from time to time on the basis of theabove mentioned theoretical topics and availability of the facilities, e.g.Assay of various spirits, tinctures, extracts, syrups and elixirs, Assay ofOintments and suppositories, Assay of tablets and capsules, Test foralkalinity of glass, Determination of alcohol contents in thePharmaceutical preparations and Pyrogen test. Sterility test,71 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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14. Ronald D Schoenwald, Pharmacokinetics in drug discovery andDevelopment, CRC Press LLC, USA, 2002.PHARM 618 PHARMACEUTICS-IX (Pharmaceutical QualityManagement-I) [Th.]Cr. Hr.: 03 Marks: 1001. INTRODUCTION:(a) Basic concepts about introduction of pharmaceutical industry inrelevance to quality assurance and quality control departments, testing,quality management system, quality assurance, quality control,Standard.(b) General understanding of good laboratory practices and validation2. QUALITY CONTROL OF SOLID DOSAGE FORMS:(a) Physical tests: Hardness, Thickness and Diameter, Friability,Disintegration, Weight Variation.(b)Chemical tests: Content uniformity, Assay of active ingredients anddissolution tests of Powders, Granules, Tablets and Capsules.3. QUALITY CONTROL OF SYRUPS AND ELIXIRS:Viscosity, itsdetermination and application in the Quality Control of Pharmaceuticals,Weight per ml and Assay of active ingredients.4. QUALITY CONTROL OF SUPPOSITORIES: Disintegration test,Uniformity of weight, Assay of active ingredients, Liquefaction time test andBreaking test.5. QUALITY CONTROL OF STERILE PRODUCTS(PARENTERALS):Sterility Test and Sterile section management, Leaker’stest, Clarity test, Pyrogen test for Parenteral and other sterile preparations,Assay for active ingredients.PHARM 619 PHARMACEUTICS-IX (Pharmaceutical QualityManagement-I) [Lab.]Cr. Hr.: 01 Marks: 50NOTE:-Practical of the subject shall be designed from time to time on the basis of theabove mentioned theoretical topics and availability of the facilities, e.g.Assay of various spirits, tinctures, extracts, syrups and elixirs, Assay ofOintments and suppositories, Assay of tablets and capsules, Test foralkalinity of glass, Determination of alcohol contents in thePharmaceutical preparations and Pyrogen test. Sterility test,71 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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