Download Pharmacy Curriculum Draft (NCRC); 2011
Download Pharmacy Curriculum Draft (NCRC); 2011 Download Pharmacy Curriculum Draft (NCRC); 2011
2. HEAT TRANSFER.3. DRYING: Theories of drying, Drying of Solids, Classification of dryers,General Methods, Fluidized Bed systems, Pneumatic systems, Spray dryer,Freeze dying.4. MIXING: Fundamentals, Mechanisms, Mixing Equipment used inLiquid/Liquid, Liquid/Solid and solid/solid mixing, Communition (sizereduction), Reasons for size reduction, Factors affecting size reduction, sizeanalysis, Sieving, Energy Mills (Ball Mill, Endrumer, Edge Rumer,Disintegrant, Colloid Mill, Hammer Mill, Cutter Mill, and Fluid Energy Milletc.).5. COMMUNITION (SIZE REDUCTION): Reasons for size reduction,Factors affecting size reduction, size analysis, Sieving, Energy Mills (BallMill, Endrumer, Edge Rumer, Disintegrant, Colloid Mill, Hammer Mill,Cutter Mill, and Fluid Energy Mill etc.).6. CLARIFICATION AND FILTRATION: Theory, Filter media, Filter aids,Filter selection and Equipment (Leaf filter, Filter press, Melta filters andRotary filters).7. EVAPORATION: General principles of Evaporation, Evaporators andEvaporation under reduced pressure.8. COMPRESSION AND COMPACTION: The solid-air Interface, Angle ofRepose, Flow rates, Mass volume relationship, Density, Heckel Plots,Consolidation, Granulation, Friability, Compression (dry method, wetmethod, slugging), Physics of Tabletting, tabletting machines and otherequipment required, problems involved in tabletting, tablet coating,Capsulation (Hard and Soft gelatin capsules).PHARM 615 PHARMACEUTICS-VII (Industrial Pharmacy-I) [Lab.]Cr. Hr.: 01 Marks: 50NOTE:- Practical of the subject shall be designed from time to time on the basis ofthe above mentioned theoretical topics and availability of the facilities,e.g. Manufacture of Tablets by Wet Granulation Method, by Slugging andby Direct Compression. Coating of Tablets (Sugar Coating, Filmcoatingand Enteric Coating). Clarification of liquids by various processes.Size Reduction. Homogenization. Ampoule filling, sealing andsterilization clarity and leakage tests in injectables. Capsule filling bysemi automatic machines. Manufacture of sustained action drugs. TabletsTests like Disintegration. Dissolution. Friability. Hardness and thicknesstests. Determination of weight variation in tablets. Density of powder.Particle size analysis.68 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
(Note: A minimum of 10 practicals will be conducted).Recommended Books:1. Lachman, Theory and Practice of Industrial Pharmacy, 3 rd Ed,VerghesePublishing House, Bombay, 2009.2. Cooper and Gunn’s, Tutorial Pharmacy, 6 th Ed, CBS Publishers &Distributors, New Delhi, 2004.3. Bentley’s Pharmaceutical Text Book, CBS Publishers & Distributors, NewDelhi, 1986.4. Remington’s Pharmaceutical Sciences, 21 st Ed, Mack PublishingCompany, USA, 2005.5. John Sharp, Good Pharmaceutical Manufacturing Practice, 6 thEd,Rational and Compliance. 2009.PHARM 616 PHARMACEUTICS-VIII (Biopharmaceutics-I) [Th.]Cr. Hr.: 03 Marks: 1001. DEFINITIONS AND TERMINOLOGY:Biopharmaceutics, GenericEquivalence, Bioavailability, Bioequivalence, Drug Disposition,Pharmacokinetics; LADMER Libtation, absorption, distribution, metabolism,elimination and response) Sustem, and Therapeutic Equivalents.2. GASTRO-INTESTINAL ABSORPTION:Forces which help intransmembrane movements, Anatomical and physiological factorsinfluencing absorption of drugs. Physicochemical properties of drugsaffecting absorption. Absorption of different oral dosage forms.3. BIOLOGICAL HALFLIFE AND VOLUME OF DISTRIBUTION:Introduction, types, methods of determination and application4. DRUG CLEARANCE:Introduction, Mechanism, Models,determination and relationship of clearance with half-life.5. PHARMACOKINETICS: Introduction, Linear and Non-linearPharmacokinetics Application of pharmacokinetics in clinical situations.6. BIOAVAILABILITY AND BIOEQUIVALENCEa. Introduction.b. Bioavailability types, parameters, significance and study protocol.c. Methods of Assessment of Bioavailabilityd. Bioequivalence study designs, components and application, report format7. CONCEPT OF COMPARTMENT(S) MODELS:I. One compartment open model.a. Intravenous Injection (Bolus) b. Intravenous infusion.II. Multicompartment models.69 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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2. HEAT TRANSFER.3. DRYING: Theories of drying, Drying of Solids, Classification of dryers,General Methods, Fluidized Bed systems, Pneumatic systems, Spray dryer,Freeze dying.4. MIXING: Fundamentals, Mechanisms, Mixing Equipment used inLiquid/Liquid, Liquid/Solid and solid/solid mixing, Communition (sizereduction), Reasons for size reduction, Factors affecting size reduction, sizeanalysis, Sieving, Energy Mills (Ball Mill, Endrumer, Edge Rumer,Disintegrant, Colloid Mill, Hammer Mill, Cutter Mill, and Fluid Energy Milletc.).5. COMMUNITION (SIZE REDUCTION): Reasons for size reduction,Factors affecting size reduction, size analysis, Sieving, Energy Mills (BallMill, Endrumer, Edge Rumer, Disintegrant, Colloid Mill, Hammer Mill,Cutter Mill, and Fluid Energy Mill etc.).6. CLARIFICATION AND FILTRATION: Theory, Filter media, Filter aids,Filter selection and Equipment (Leaf filter, Filter press, Melta filters andRotary filters).7. EVAPORATION: General principles of Evaporation, Evaporators andEvaporation under reduced pressure.8. COMPRESSION AND COMPACTION: The solid-air Interface, Angle ofRepose, Flow rates, Mass volume relationship, Density, Heckel Plots,Consolidation, Granulation, Friability, Compression (dry method, wetmethod, slugging), Physics of Tabletting, tabletting machines and otherequipment required, problems involved in tabletting, tablet coating,Capsulation (Hard and Soft gelatin capsules).PHARM 615 PHARMACEUTICS-VII (Industrial <strong>Pharmacy</strong>-I) [Lab.]Cr. Hr.: 01 Marks: 50NOTE:- Practical of the subject shall be designed from time to time on the basis ofthe above mentioned theoretical topics and availability of the facilities,e.g. Manufacture of Tablets by Wet Granulation Method, by Slugging andby Direct Compression. Coating of Tablets (Sugar Coating, Filmcoatingand Enteric Coating). Clarification of liquids by various processes.Size Reduction. Homogenization. Ampoule filling, sealing andsterilization clarity and leakage tests in injectables. Capsule filling bysemi automatic machines. Manufacture of sustained action drugs. TabletsTests like Disintegration. Dissolution. Friability. Hardness and thicknesstests. Determination of weight variation in tablets. Density of powder.Particle size analysis.68 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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