Download Pharmacy Curriculum Draft (NCRC); 2011
Download Pharmacy Curriculum Draft (NCRC); 2011 Download Pharmacy Curriculum Draft (NCRC); 2011
hydride reduction and wolf krishnner reduction friedel craft’s reaction,Perkin reaction, Cannizzaro reaction. Mannich Reaction3. REACTIVE INTERMEDIATES AND FREE RADICALS: Introduction,Generation, stability and Reaction of the following intermediates:Carbocations, Carbanions, Carbenes, Nitrenes,Benzynes, Type ofreactions:An Overview. Free radicals, Free radical scavengers and theirapplications.4. CARBONIUM ION REARRANGEMENTS: Pinacol-Pinacolone, wigner-Meerwein, Wolf, Hofmann and Beckmann rearrangements.5. CARBANIONS: Condensation reaction (Aldol condensation Favorskiirearrangement; writing reaction)PHARM 323 PHARMACEUTICAL CHEMISTRY-II (ORGANIC-I)[Lab.]Cr. Hr.: 01 Marks: 50NOTE: - Practicals of the subject shall be designed from time to time on the basis ofthe above mentioned theoretical topics and availability of the facilities, e.g.OrganicPreparations: Benzoic acid, Aspirin, Acetanilide, Iodoform, Nitrophenol, 3-nitrophthalic acid, Benzhydrol and 2,4-Dinitrochlorobenzene.Recommended Books:1. Peter Sykes, A guide Book to Mechanism in Organic Chemistry,Longman, New York, 6 th Ed, 1991.2. E L Eliel, Stereochemistry of Carbon Compounds, Tata McGraw- Hill,New Delhi, 1992.3. Rehman and M Younis, Organic Chemistry for B.Sc. students, IlmiKitab Khana, Lahore, 1997.4. L Finar, Organic Chemistry Vol I, Person Education Asia, 6th Ed., NewDelhi, 2001.5. Raj K Bansel, Organic Reaction Mechanism, Tata McGraw-Hill, NewDelhi, 1992.6. Furaiss Brian, Practical Organic Chemistry, 5th Ed., ELBS, London.7. Sykes A P, Guide Book to Mechanism in Organic Chemistry, 6th Ed.,Lonsmen Co, UK, 2008.8. Roberts J D and Caserio M C, Basic Principles of organic Chemistry,24 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
1990.9. Naser-ud-Din, Introduction to Stereochemistry, Ghafoor StationeryMart, Peshawar, 1994.10. Bhal B S, Textbook of Organic Chemistry, S Chand & Co, New Delhi,16 th Ed., 2007.11. L.G. Wade, Organic Chemistry, Prentice Hall, New York, U.S.A., 7 thEd., 2010.PHARM 324 PHARMACEUTICAL BIO-CHEMISTRY-II [Th.]Cr. Hr.: 03 Marks: 1001. METABOLIC FATE OF BIOMOLECULES (Anabolism and Catabolism):a. Carbohydrates: Introduction to metabolism, Brief introduction to the digestionand absorption of carbohydrates, Aerobic and anaerobic breakdown of Glucose,Glycolysis, Pentose Phosphate Pathway, Glycogenolysis, Glycogenesis,Gluconeogenesis, Citric acid cycle, Energetics of various metabolic processes.b. Lipids: Brief introduction to the digestion and absorption of lipids, Oxidation offatty acids through b-oxidation, Biosynthesis of fatty acids, neutral lipids andcholesterol.c. Proteins and Amino acids: Brief introduction to the digestion and absorption ofproteins and amino acids, Metabolism of essential and non-essential aminoacids, Biosynthesis and catabolism of Haemins and porphyrin compounds.d. Bioenergetics: Principles of bioenergetics. Electron transport chain andoxidative phosphorylation.2. REGULATION OF METABOLIC PROCESSESa. Role of Vitamins: Physiological role of Fat-soluble (A, D, E and K) andWater-soluble (Thiamin, Riboflavin, Pantothenic acid, Niacin, Pyridoxalphosphate, Biotin, Folic acid, Cyanocobalamin- members of B-complex familyand Ascorbic acid), Coenzymes and their role in the regulation of metabolicprocesses.b. Receptor mediated regulation (Hormones): Mechanism of action of hormones,Physiological roles of various hormones, Site of synthesis and target sites ofhormones.c. Secondary Messengers: Role of cAMP, Calcium ions and phosphoinositol in theregulation of metabolic processes.d. Gene Expression: Replication, Transcription and Translation (Gene expression)Introduction to Biotechnology and Genetic Engineering, Basic principles ofRecombinant DNA technology, Pharmaceutical applications, Balance ofCatabolic, Anabolic and Amphibolic processes in human metabolism, Acid-Base and Electrolyte Balance in Human body.3. INTRODUCTION TO CLINICAL CHEMISTRY:Introduction and Importanceof25 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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hydride reduction and wolf krishnner reduction friedel craft’s reaction,Perkin reaction, Cannizzaro reaction. Mannich Reaction3. REACTIVE INTERMEDIATES AND FREE RADICALS: Introduction,Generation, stability and Reaction of the following intermediates:Carbocations, Carbanions, Carbenes, Nitrenes,Benzynes, Type ofreactions:An Overview. Free radicals, Free radical scavengers and theirapplications.4. CARBONIUM ION REARRANGEMENTS: Pinacol-Pinacolone, wigner-Meerwein, Wolf, Hofmann and Beckmann rearrangements.5. CARBANIONS: Condensation reaction (Aldol condensation Favorskiirearrangement; writing reaction)PHARM 323 PHARMACEUTICAL CHEMISTRY-II (ORGANIC-I)[Lab.]Cr. Hr.: 01 Marks: 50NOTE: - Practicals of the subject shall be designed from time to time on the basis ofthe above mentioned theoretical topics and availability of the facilities, e.g.OrganicPreparations: Benzoic acid, Aspirin, Acetanilide, Iodoform, Nitrophenol, 3-nitrophthalic acid, Benzhydrol and 2,4-Dinitrochlorobenzene.Recommended Books:1. Peter Sykes, A guide Book to Mechanism in Organic Chemistry,Longman, New York, 6 th Ed, 1991.2. E L Eliel, Stereochemistry of Carbon Compounds, Tata McGraw- Hill,New Delhi, 1992.3. Rehman and M Younis, Organic Chemistry for B.Sc. students, IlmiKitab Khana, Lahore, 1997.4. L Finar, Organic Chemistry Vol I, Person Education Asia, 6th Ed., NewDelhi, 2001.5. Raj K Bansel, Organic Reaction Mechanism, Tata McGraw-Hill, NewDelhi, 1992.6. Furaiss Brian, Practical Organic Chemistry, 5th Ed., ELBS, London.7. Sykes A P, Guide Book to Mechanism in Organic Chemistry, 6th Ed.,Lonsmen Co, UK, 2008.8. Roberts J D and Caserio M C, Basic Principles of organic Chemistry,24 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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