Download Pharmacy Curriculum Draft (NCRC); 2011

F I N A L P R O F E S S I O N A LPHARMACEUTICAL CHEMISTRY-IV (MEDICINAL CHEMISTRY)(WRITTEN)Paper 1Note:100 MarksThe topics will be taught with special reference to their Pharmaceutical Applications.1. INTRODUCTION TO MEDICINAL CHEMISTRY:Chemical constitution and biological activity: (Receptor, Theory, StructureActivity Relationships (SAR) and Drug Metabolism). Modern concept of rationaldrug design, pro drug, combinatorial chemistry and computer aided drug design(CADD) and concept of antisense molecules.2. DRUG TARGETS AND DRUG DESIGNING:i. Introduction and types of Drug targetsii. Introduction to Molecular modeling and computational chemistryiii. Structure based designingiv. Ligand-based designingv. Various techniques in drug synthesis3. GENERAL PROPERTIES, CHEMISTRY BIOLOGICALACTION,STRUCTURE ACTIVITY RELATIONSHIP ANDTHERAPEUTICAPPLICATIONS OF THE FOLLOWING:(a) Hormones: Steroidal Hormones (Testosterone, Progesterone, Estrogen,Aldosteron and Cortisol), Proteinous Hormones (Insulin, Glucagon, Oxytocinand Vassopressin).(b) Anti-neoplasticAgents: Tamoxifen, Fluorouracil, Mercapturine, Methotrexateand Vincristine.(c) Sedatives and Hypnotics: Benzodiazepines, Barbiturates, Paraldehyde,Glutethimide, Chloral hydrate, and alcohols.(d) Anaesthetics: Local anaesthetics (Procaine, Lignocaine, Eucaine, Cocaine andBenzocaine), General anaesthetics (Cyclopropane, Halothane, Nitrous oxide,Chloroform, Thiopental Sodium, Ketamine, Methohexital, Thioamylal Sodium,Fantanyl Citrate, Tribromo ethanol).161 | Pakistan Pharmacist Federation; www.pharmacistfed.pk, www.pharmafed.wordpress.com,www.pharmarev.com, info@pharmacistfed.pk,