Download Pharmacy Curriculum Draft (NCRC); 2011

Delhi, 1986.4. Remington’s Pharmaceutical Sciences, 21 st Ed, Mack PublishingCompany, USA, 2005.5. John Sharp, Good Pharmaceutical Manufacturing Practice, 6 thEd,Rational and Compliance. 2009.PHARMACEUTICS –V (BIOPHARMACEUTICS) (WRITTEN)Paper 4100 Marks1. DEFINITIONS AND TERMINOLOGY:Biopharmaceutics, GenericEquivalence, Bioavailability, Bioequivalence, Drug Disposition,Therapeutics, Pharmacokinetics; LADMER (Liberation, absorption,distribution, Metabolism, elimination and Response) System; andTherapeutic Equivalents.2. GASTRO-INTESTINAL ABSORPTION:Forces which help intransmembrane movements, Anatomical and physiological factorsinfluencing absorption of drugs. Physicochemical properties of drugsaffecting absorption. Absorption of different oral dosage forms.3. BIOLOGICAL HALFLIFE AND VOLUME OF DISTRIBUTION:Introduction, types, methods of determination and application4. DRUG CLEARANCE:Introduction, Mechanism, Models,determination and relationship of clearance with half-life.5. PHARMACOKINETICS: Introduction, Linear and Non-linearPharmacokinetics Application of pharmacokinetics in clinical situations.6. BIOAVAILABILITY AND BIOEQUIVALENCEa. Introduction.b. Bioavailability types, parameters, significance and study protocol.c. Methods of Assessment of Bioavailabilityd. Bioequivalence study designs, components and application, report format7. CONCEPT OF COMPARTMENT(S) MODELS:I. One compartment open model.155 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,