Department of Pathology & Genetics Genetics Centre
Department of Pathology & Genetics Genetics Centre
Department of Pathology & Genetics Genetics Centre
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CategoryPostnatalDiagnosis*TestPeripheral BloodCulture (Karyotype)Fanconi AnemiaFluorescence in situhybridization (FISHonly) - BloodChorionic VillusSample (CVS) -KaryotypeChorionic VillusSample (CVS) - FISH +Karyotype<strong>Department</strong> <strong>of</strong> <strong>Pathology</strong> & <strong>Genetics</strong><strong>Genetics</strong> <strong>Centre</strong>Cytogenetics UnitService ListReferencecodeSampleTAT (Days)Price(UAE Dhs)L03543-5ml <strong>of</strong> fresh venousblood taken in a14-21 700lithium heparinL0352 (green tube)14-21 700vacutainerL0362L0355L03663-5 ml bloodin lithium heparintubeCVS in sterile culturemediaCVS in sterile culturemedia5-7 100014-21 900FISH 48 hoursKaryotype14-21 Days1400PrenatalDiagnosisAmniocentesis (AF) -KaryotypeL035115 mlAmniotic Fluid14-21 900Amniocentesis (AF) –KaryotypeFISH + KaryotypeL036515 mlAmniotic FluidFISH 48 hoursKaryotype14-21 Days1400Cord Blood (PUBS) –KaryoptypeL03573-5 ml bloodin lithium heparintube7-10 700CancerCytogeneticsLeukemia - KaryotypeLymphoma - KaryotypeSolid Tumor -KaryotypeBone Marrow(FISH + Karyotype)L0359Bone marrowin lithium heparin tube7-10 900L0369 Tumor tissue 7-14 1000L0367Bone marrowin lithium heparin tube7-10 1400Solid Tumor( FISH + Karyotype)L0368Tumor tissue in sterilemedia7-14 1400Page 1 <strong>of</strong> 4Cytogenetics Unit, Tel: +971-4-2193454/9, Toll Free: 800GENE (4363), Fax: +971-4-3113247, P.O.Box:9115, Dubai, U.A.E, e-mail: skmurthy@dha.gov.ae
CancerCytogeneticsBreast Cancer -Her2/neu FISHL0370Prepared 5 micronUnstained histologyslides5-7 1100Prader-Willi syndrome(15q11 - q13)Angelman syndrome(15q11 - q13)Miller Dieker syndrome(17p13)Smith-Magenissyndrome (17p11)MolecularCytogenetics(MicrodeletionSyndromes)FISH&KaryotypeWilliams syndrome(7q11.2)DiGeorge/Velocardi<strong>of</strong>acial syndrome(22q11.2)22q13.3 deletionsyndrome1p36 deletionsyndromeL03633-5 ml bloodin lithium heparin tube5-7 1400Cri-du-chat (5p-)Kallman syndrome(Xp22.3)Steroid SulfataseDeficiency (STS)(Xp22.3)SRY (Yp11)Bone Marrow / SolidTumorBcr/ablt(9;22)(q34;q11.2)Hematology/OncologyFISH andKaryotypePML/RARAt(15;17)(q22;q21.1)TEL/AML1t(12;21)(p13;q22)L03673-5 ml bloodin lithium heparin tube7-10 1400AML-M4eoinv(16)IGH/CCND1t(11;14)(q13;q32)Burkitt's lymphomat(2;8) , t(8;14) , t(8;22)Page 2 <strong>of</strong> 4Cytogenetics Unit, Tel: +971-4-2193454/9, Toll Free: 800GENE (4363), Fax: +971-4-3113247, P.O.Box:9115, Dubai, U.A.E, e-mail: skmurthy@dha.gov.ae
MLL 11q23Hematology/OncologyALLTrisomy8CLL del(13q) Trisomy12L0367Bone marrowin lithium heparin tube 7-10 1400Retinoblastomadel(13)(q14)Y microdeletionby PCR(Male infertility)Whole GenomeMicroarray study20 STS markersincluding DAZ, AZFa,AZFb, AZFc, SRY andothersY-microdeletion +karyotypeChromosomalMicroarrayCMA 105L039110 ml Whole blood5-7 500in EDTA tubeL039214-21 1000L0397 10ml whole in EDTA tube 4-6 Weeks 3000Fibroblast (Skin)Fibroblast (Skin)KaryotypeL0364Skin tissue in steriletransport media4-5 Weeks 900FamilyScreeningChromosomes(Parents only)Peripheral BloodCulture (Karyotype)L03963-5ml <strong>of</strong> fresh venousblood taken in a lithiumheparin(green tube)Vacutainer14-21 700A complete request form including all details <strong>of</strong> the patient and reason for referral is mandatory. The requestform can be down loaded from the website.Please note: All FISH tests will be carried out depending on the availability <strong>of</strong> the specific probe. Pricing formore than one probe set used (e.g. in CML, AML, ALL etc) will vary depending on the battery <strong>of</strong> test requiredfor the specific diagnosis.Please call and confirm before ordering the test.* For Stat cases (e.g. SBCU babies etc.) the reporting turn around time (TAT) for peripheral blood karyotypingis 5 days. Please indicate in the request.**Microarry testing by array-CGH is <strong>of</strong>fered on special request. Please call for further information.*** Please note that the general tissue culture failure rate (international statistics) for product <strong>of</strong> conception (POC) isaccepted to be around 40% due to unavoidable reasons such as tissue type, cell viability, method <strong>of</strong> collection,Page 3 <strong>of</strong> 4Cytogenetics Unit, Tel: +971-4-2193454/9, Toll Free: 800GENE (4363), Fax: +971-4-3113247, P.O.Box:9115, Dubai, U.A.E, e-mail: skmurthy@dha.gov.ae
sterility, time <strong>of</strong> collection, delay in sending the sample, etc. CVS and/or skin sample <strong>of</strong> the fetus is found to be thebest suitable tissue for successful tissue culture <strong>of</strong> POC.Note: Test pricing is subject to be change upon periodical reviews.Sending samples to the cytogenetic laboratory :1) For Peripheral Blood Chromosomal analysis, 3-5ml <strong>of</strong> fresh venous blood taken in a lithium heparin (green tube)vacutainer tube .After collection shake the tube by inverting a couple <strong>of</strong> times to avoid clotting. Blood sampleswill be accepted on Sundays, Mondays and Thursdays only.2) Bone marrow samples: Collect 2-3 ml <strong>of</strong> bone marrow in green cap lithium heparin tube. Avoid clotting byinverting the tube a couple <strong>of</strong> times after collection. Samples will be accepted from Sunday-Wednesday.3) For prenatal diagnosis amniotic fluid (15 ml, no blood contamination) and chorion villi sample (CVS in sterileculture media) to be collected in sterile tube. Before collection <strong>of</strong> sample please call the lab to obtain these tubes.4) Do not freeze any sample. If required to be stored overnight, keep at 4 o C.All samples should be sterile, transportedat room temperature and must reach the laboratory before 1.00 p.m.For more information please contact:Dr. Sabita K. Murthy (Consultant & Head <strong>of</strong> Cytogenetics Unit) : +971 4 219 3454Cytogenetics Laboratory: +971 4 219 3459skmurthy@dha.gov.aeUpdated on Nov, 2010Page 4 <strong>of</strong> 4Cytogenetics Unit, Tel: +971-4-2193454/9, Toll Free: 800GENE (4363), Fax: +971-4-3113247, P.O.Box:9115, Dubai, U.A.E, e-mail: skmurthy@dha.gov.ae