New Drugs Antiplatelets-Antithrombotics - John Fanikos, RPh, MBA ...
New Drugs Antiplatelets-Antithrombotics - John Fanikos, RPh, MBA ...
New Drugs Antiplatelets-Antithrombotics - John Fanikos, RPh, MBA ...
- No tags were found...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
BOREALIS-AFBiotinylated IdraparinuxCASSEOPEIANon-Valvular AFPrior Stroke or TIA>2 Risk factorsSymptomaticPulmonaryEmbolism+/- DVTRRWarfarin INRadjustedOnce DailyBiotinylatedIdraparinux 3.0mgOnce WeeklyEnoxaparin 1 mg per kg dailyWarfarin INRadjustedOnce DailyBiotinylatedIdraparinux 3.0mgOnce Weekly1. All strokes or non CNSsystemic embolic events2. Major Bleeding or Death1. Recurrence of VTE at 3 and 6months2. Major BleedingPatients Reaching PrimaryEndpoint in 7 DaysDEATH OR MI in 7 Days65432108765432107.24.6SEPIA-ACS1 TIMI 42 Results3.8 3.60.035 0.07 0.105 0.14 0.175 UFH+Ept4.8Death, MI, UrgentRevascularization2.8Dose (mg/kg/hr)4.3RR vs 1.16 0.74 0.61 0.58 0.69ControlDeath or MI at 7 Days2.6 2.7 2.80.035 0.07 0.105 0.14 0.175 UFH+EptDose (mg/kg/hr)RR vs 0.98 0.57 0.52 0.56 0.58Control6.24.9Patients with ThromboticComplications During PCITIMI Major and MInorBleeding7654321065432106.2Thrombotic ComplicationsDuring PCI52.90.035 0.07 0.105 0.14 0.175 UFH+Ept1.6 1.63.5Dose (mg/kg/hr)3.10.035 0.07 0.105 0.14 0.175 UFH+Ept3.4Dose (mg/kg/hr)3.2RR vs 2.52 2.06 1.17 1.44 1.31ControlMajor or Minor BleedingRR vs 0.61 0.61 1.15 1.26 2.02ControlSabatine M. et al. Lancet 2009;374:787-7955.42.42.7REG1 Anticoagulation System• Comprisedof anaptamerbasedanticoagulant• RB006, &its matchedantidote,RB007REG1AnticoagulationSystem• Comprised of anaptamer-basedanticoagulant• Protein bindingoligonucleotide• Direct IXainhibitor•RB006, & itsmatched antidote,RB007Dyke CK. Circulation2006:114:2490-2497Baseline DataStudyDrugTimeline of ProceduresInformed consent will be executed prior to administration of any sedativesClopidogrel 600 mg loading dose and ASA 250-500 mg at least 4 hours prior to PCIPatients who receive heparin during diagnostic cath will wait at least 4 hours for the PCI procedureACTPTT (lab)Whole BloodPTT (POC)5 min 15 minPCIEndTnT, CKMB, CK q8h x 3Immediately Post4 hoursPCIRoll-In andRoll-In andGroup IGroup I:Complete ReversalPartial Reversaland Sheath PullororGroup II:HeparinComplete ReversalSheath PullandSheath Pull14 daysEnd of Follow-upIndefiniteASAClopidogrelrecommend12 months