Royan International Research Award - Royan Institute

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ANNUAL REPORTROYAN I n s t i t u t eThe institute’s vision is to attain new heights in biotechnology research, shaping biotechnology into a premierprecision tool of the future for creation of wealth, ensuring social justice and also efficiently bridging sciencewith daily life.Department of Reproduction and DevelopmentThe mechanisms of in vivo and in vitro embryo development are of paramount importance in the field ofAssisted Reproductive Technology (ART), dairy farming and biopharming. Although much effort has been putinto the establishment of sequential media, further advances are required in order to overcome in vitro stressfor embryo development.Main goals within this research area• Establishment of different methods for somatic cell nuclear transfer (SCNT) or cloning• Production of transgenic animals via cloning, sperm and germ cells• Production of novel culture media for in vitro embryo development• Cryopreservation of gametes, embryos and reproductive tissues• Increasing cloning efficiency by epigenetic modification• Establishment of a screening test for the assessment of sperm integrity• Establishment of novel sperm selection procedures for ARTThe mission of this department is to achieve world-class applicative approaches in transgenesis in the hope ofproducing recombinant proteins.Focused areas of the department• Somatic cell nuclear transfer• Transgenesis• Cryobiology• Novel sperm selection procedure• Sperm functional tests• Sperm biologyDepartment of Molecular BiotechnologyFollowing the production of the first recombinant protein in 1978, insulin, extensive research has been undertakenfor the purpose of producing other recombinant proteins. Different strategies can be utilized for the productionof recombinant proteins; which include proteins produced via bacteria, plants, cell culture and through milkproduction in transgenic animals. Although the production of recombinant proteins through the former methodsmight be the easiest and most straight forward procedures; however, research has shown that the production ofrecombinant proteins through the latter methods might be more functional due to post-translational modifications,which are very similar to the native protein. Therefore, one of the main missions of this group is to master andestablish efficient methods for producing recombinant proteins through cell culture and animal transgenesis.The main goals of this department• Production and construction of efficient vectors for producing recombinant proteins• Cloning of appropriate genes• Genetic manipulation of the genes for pharmaceutical purposes• Increasing gene transfection through non-viral procedures• Isolation and maintenance of the stable transformants of mammalian cells• Homologous or site directed recombination of genes into a target genome78
ANNUAL REPORTDepartment of Cell and Molecular BiologyHead of DepartmentDr Mohammad HosseinNasr EsfahaniPrincipal Investigators<strong>Research</strong> AssistantsPhD in EmbryologyUniversity of CambridgeDepartment of AnatomyGamete and Embryology groupUK-CB2-3DY.1988-1991BSc Human BiologyUniversity of LondonKing’s College London.1985-1988EmbryologistHallam Medical Centre, UK1991-1992•••••M. Hosseini, DVMKh. Karbalaei, MScY. Khazaei, PhDS. Tanhaei, MScM. Tavalaei, MSc• M. R. Deemeh, MSc• K. Dormiani, PhD• Mo. Forouzanfar, PhD• K. Ghaedi, PhD• M. Hajian, MSc• M. A. Hamiditabar, MD• F. Karamali, MSc• A. Khaghani, DVM• S. H. Khodaei, MSc• A. Kiani, MSc• Z. Nasiri, MSc• S. Ostad Hosseini, MSc• A. Salamian, MSc• F. Shadanlo, MSc79
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Royan International Research Award - Royan Institute

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