zetrine syrup - Lomus Pharmaceuticals Pvt. Ltd.

ZETRINE Tablet/SyrupDosage Forms/CompositionTablet: Each film coated tablet contains cetrizine dihydrochloride 10 mgSyrup: Each 5 ml contains contains cetrizine dihydrochloride 5 mgPharmacological IndexAntihistamineINDICATIONSymptomic relief of allergic conditions (hayfever, urticaria, rhinitis, conjunctivitis),angioedema, Kimura's disease.Pregnancy Risk FactorBContraindicationsHypersensitivity to cetirizine, hydroxyzine, or any componentWarnings/PrecautionsCetirizine should be used cautiously in patients with hepatic or renal dysfunction andthe elderly. Use in breast-feeding women is not recommended. Doses >10 mg/day maycause significant drowsiness.Adverse Reactions>10%: Central nervous system: Headache has been reported to occur in 10% to 12% ofpatients, drowsiness has been reported in as much as 26% of patients on high doses1% to 10%:Central nervous system: Somnolence, fatigue, dizzinessGastrointestinal: Xerostomia

tract, blood vessels, and respiratory tract.Pharmacodynamics/KineticsOnset of effect: Within 15-30 minutesAbsorption: Oral: RapidMetabolism: Exact fate is unknown, limited hepatic metabolismHalf-life: 8-11 hoursTime to peak serum concentration: Within 30-60 minutesUsual DosageAdults: 10 mg once dailt or 5 mg bid.Children: 6 months-2 years: 2.5 mg once daily2.5 years: 5mg once daily or 2.5 mg bid> 6 years: 10mg once daily or 5 mg bidPatient InformationTake as directed; do not exceed recommended dose. Avoid use of other depressants,alcohol, or sleep-inducing medications unless approved by prescriber. You mayexperience drowsiness or dizziness (use caution when driving or engaging in tasksrequiring alertness until response to drug is known); or dry mouth, (frequent smallmeals, frequent mouth care, chewing gum, or sucking hard candy may help). Reportpersistent sedation, confusion, or agitation; persistent nausea or vomiting; changes inurinary pattern; blurred vision; chest pain or palpitations; or lack of improvement orworsening or condition. Breast-feeding precautions: Breast-feeding is notrecommended.LOMUS Drug Information CenterLomus Pharmaceuticals Pvt. Ltd.P.O. Box No 4506, Lomus House (Corporate office),Kailash Chour, Lazimpat, Kathmandu, NepalPh: 4436396 (Hunting Line). Fx: 977-1-4436395E-mail: druginfo@lomus.com.np