helmapren susp. - Lomus Pharmaceuticals Pvt. Ltd.

Drug InteractionsMay inhibit CYP1A2 enzyme (mild)Increased effect: Dexamethasone increases plasma levels of albendazole metabolites;praziquantel may increase plasma concentrations of albendazole by 50%; albendazoleinhibits hepatic cytochrome P-450 1A and may consequently interact by increasing theconcentrations of many drugs which are metabolized by this route; food (especiallyfatty meals) increases the oral bioavailability by 4-5 timesMechanism of ActionActive metabolite, albendazole, causes selective degeneration of cytoplasmicmicrotubules in intestinal and tegmental cells of intestinal helminths and larvae;glycogen is depleted, glucose uptake and cholinesterase secretion are impaired, anddesecratory substances accumulate intracellulary. ATP production decreases causingenergy depletion, immobilization, and worm death.Pharmacodynamics/KineticsAbsorption: Oral absorption is poor (