Paper Code: BPL-401Pharmaceutical Chemistry-IX (Medicinal Chemistry-II)L -- T -- P Total Credits: 044 -- -- Total Marks: 100External Marks: 50Internal Marks: 50Paper Objectives: Study of this subject covers the theory of drug action, stereochemistry <strong>and</strong>drug action, alkaloids <strong>and</strong> relation of structure <strong>and</strong> biological activity of organic medicinalagents. Protein <strong>and</strong> steroidal hormones, antibiotics, <strong>and</strong> synthetic drugs of differentpharmacological activity are also included.Synthetic procedures of selected drugs, mode of action, uses, structure activityrelationship including Physico-Chemical properties of the following classes of drugs:UNIT I Steroids <strong>and</strong> related drugs: Steroidal nomenclature <strong>and</strong> stereochemistry, <strong>and</strong>rogens<strong>and</strong> anabolic agents, estrogens, <strong>and</strong> progestational agents, adrenocorticoids.UNIT IIGeneral AnestheticsLocal AnestheticsHypnotics <strong>and</strong> SedativesOpioid analgesicsAntitussivesAnticonvulsantsAntiparkinsonism drugsCNS stimulantsPsychopharmacological agents (neuroleptics, antidepressants, anxiolytics).UNIT IIIDiureticsCardiovascular drugsAnticoagulant <strong>and</strong> Antiplatelet drugs.Biochemical approaches in drug designing wherever applicable should be discussed.UNIT IV Synthetic procedures of following selected drugs: Procaine, Benzocaine,Lignocaine, Cinchocaine, Thiopentone, Phenobarbitone, Hexobarbitone, Diazepam,Mehtaqualone, PheNew Yorktoin, Troxidone, Pethidine, N-methylmorphine,Chlorpromazine, Trifluoperazine, Amitryptiline, Nikethamide, Cholesterol,Dihydroepi<strong>and</strong>rosterone, Oestradiol, Diethylstilbosterol, Progesterone, Cortisoneacetate, Stigmasterol, Norethisterone, Testosterone, Triamcinolone, Furosemide,Acetazolamide, Chlorthiazide, Hydrochlorthiazie, Spironolactone, Triametrene,106
Nifedipine, Procainamide, Verapamil, Propranolol, Methyldopa, Clonidine,Guanethidine, Hydrallazine, Phentolamine, Clofibrate, Warfarin, Phenindione.Note: Instruction for Examiner:The Semester examination in each theory subject shall be of 50 marks. The examiner will setnine questions. Student will attempt five questions. First question would be of short answertype question covering all four Units (2.5 Marks per Unit) & it would be compulsory. Twoquestions will be set from each unit & out of which c<strong>and</strong>idate will attempt one question. EachQuestion shall be of 10 marks.Suggested Readings (Latest Editions):1. Wilson <strong>and</strong> Gisvold’s, “Textbook of Organic Medicinal <strong>and</strong> PharmaceuticalChemistry”, Philadelphia: J. Lippincot Co.2. W. O. Foye, “Principles of Medicinal Chemistry”, Philadelphia: Lea <strong>and</strong> Febiger.3. C. Hansch, “Comprehensive Medicinal Chemistry”, Pregman Press Oxford.4. Y. C. Martin, “Quantitative Drug Design”, New York: Marcel Dekker, Inc.5. M. E. Wolff, “Burger’s Medicinal Chemistry”, New York: John Wiley & Sons.6. T. Nogardy, “Medicinal Chemistry – A Biochemical Approach”, New York, Oxford:Oxford University Press.107