Ordinance and Syllabus - Bhagat Phool Singh Mahila ...

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Paper Code: BPL-302Pharmaceutical Chemistry-VIII (Medicinal Chemistry-I)L -- T -- P Total Credits: 044 -- -- Total Marks: 100External Marks: 50Internal Marks: 50Paper Objectives:Objective of this subject is to understand the Basic Principles of Medicinal Chemistry& modern approaches for drug designing. Paper also covers synthetic procedures,mode of action, uses, structure activity relationship including physicochemicalproperties of some classes of drugs.UNIT IBasic Principles of Medicinal Chemistry: Physico-chemical aspects (Optical,geometric and bio-isosterism) of drug molecules and biological action, Drug-receptorinteraction including transduction mechanisms.Principles of Drug Design (Theoretical Aspects): Traditional analog (QSAR) andmechanism based approaches (Introduction of graph theory, applications of quantummechanics, Computer Aided Drug Designing (CADD) and molecular modeling.UNIT IISynthetic procedures of selected drugs, mode of action, uses, structure activityrelationship including physicochemical properties of the drugs acting at Synapticand neuro-effector junction sites:Cholinergics and Anticholinesterases.Adrenergic drugs.Antispasmodic and anti ulcer drugs.Neuromuscular blocking agents.UNIT IIISynthetic procedures of selected drugs, mode of action, uses, structure activityrelationship including physicochemical properties of the following classes ofdrugs:Antihistamines.Eicosanoids.Analgesic-antipyretics, anti-inflammatory (non-steroidal) agents.Drugs affecting uterine motility: Oxytocics (including oxytocin, ergot alkaloids andprostaglandins).Biochemical approaches in drug designing wherever applicable should be discussed.UNIT IV Synthetic procedures of following selected drugs: Adrenaline, Phenylephrine,Edorphonium Chloride, Dicyclomine, Neostigmine bromide, Cyclopentolate HCl,92
Propanthaline bromide, Benzhexol, Omeprazole, Pentoprazole, Rabeprazole,Ranitidine, Roxatidine, Diphenhydramine, Chlorpheneramine, Promethazine,Mepyramine, Cyclizine, Sodium chromoglycollate, Aspirin, Ibuprofen, Indomehtacin,Phenazone, Phenyllbutazone, Oxyphenbutazone, Diclofenac, Piroxicam, Tenoxicam,Celecoxib, Valdecoxib,Allopurinol, Probenecid.Note: Instruction for Examiner:The Semester examination in each theory subject shall be of 50 marks. The examiner will setnine questions. Student will attempt five questions. First question would be of short answertype question covering all four Units (2.5 Marks per Unit) & it would be compulsory. Twoquestions will be set from each unit & out of which candidate will attempt one question. EachQuestion shall be of 10 marks.Suggested Readings (Latest Editions):1. Wilson and Gisvold’s, “Textbook of Organic Medicinal and PharmaceuticalChemistry”, Philadelphia: J. Lippincot Co.2. W. O. Foye, “Principles of Medicinal Chemistry”, Philadelphia: Lea and Febiger.3. C. Hansch, “Comprehensive Medicinal Chemistry”, Pregman Press Oxford.4. Y. C. Martin, “Quantitative Drug Design”, New York: Marcel Dekker, Inc.5. Exploring QSAR• Vol. I- C. Hansch and A. Leo.,“Fundamentals and Applications in Chemistryand Biology”, Washington: American Chemical Society.• Vol.II- C. Hansch, A. Leo and D. Hockman, “Hydrophobic, Electronic andSteric Constants”, Washington: ACS Books Catalog.6. M. E. Wolff, “Burger’s Medicinal Chemistry”, New York: John Wiley & Sons.7. T. Nogardy, “Medicinal Chemistry – A Biochemical Approach”, New York, Oxford:Oxford University Press.93
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BPS Mahila Vishwavidyalaya, Khanpur
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7.2 The examination in each semeste
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9.4 Adhoc Grace:If there is any dis
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10. Promotion:11. Division:WhereCi
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16. General Guidelines:16.1 Where t
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Drug chargesPre-packagingCentral st
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Note: Instruction for Examiner:The
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Autonomic nervous system: Physiolog
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Paper Code: BPL-107 REMEDIAL BIOLOG
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Suggested Readings (Latest Editions
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Paper Code: BPP-113Pharmaceutical C
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Paper Code: BPP-117REMEDIAL BIOLOGY
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products i.e. PVP, Dextran, absorba
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Suggested Readings (Latest Editions
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Note: Instruction for Examiner:The
Page 31 and 32: Note: Instruction for Examiner:The
Page 33 and 34: Paper Code: BPP-112 Pharmaceutical
Page 37 and 38: measurement, large-scale equipment
Page 39 and 40: UNIT IVComplexometric Titrations: C
Page 41 and 42: Pyridine-piperidine: tobacco, areca
Page 45 and 46: nuclear hazards, Solid waste manage
Page 47 and 48: NOTE:Types of listeningStrategies f
Page 51 and 52: Paper Code: BPL-202Pharmaceutical C
Page 55 and 56: Paper Code: BPL-206Pharmaceutics-V
Page 57 and 58: Paper Code: BPL-208Computer Science
Page 59 and 60: Paper Code: BPL-210Pharmaceutical M
Page 61 and 62: Paper Code: BPP-212Pharmaceutical C
Page 63 and 64: Paper Code: BPP-216Pharmaceutics-V
Page 65 and 66: Paper Code: BPL-301 Pharmaceutical
Page 67 and 68: Paper Code: BPL-303 Pharmaceutics-V
Page 69 and 70: Paper Code: BPL-305Pharmaceutics-VI
Page 71 and 72: Paper Code: BPL-307Pharmacology-II
Page 73 and 74: Paper Code: ENG-301Communication Sk
Page 75 and 76: Paper Code: FFA-100Communicative Fr
Page 77 and 78: Paper Code: LAW- 001Legal LiteracyL
Page 81: Paper Code: BPP-313Pharmaceutics-VI
Page 87 and 88: Suggested Readings (Latest Editions
Page 93 and 94: Paper Code: BPP-314Pharmaceutics-VI
Page 95 and 96: Paper Code: BPP-318Pharmacology-III
Page 97 and 98: Nifedipine, Procainamide, Verapamil
Page 99 and 100: Packaging of Pharmaceutical Product
Page 103 and 104: UNIT IVAnti-epileptics drugs.Anti-P
Page 105 and 106: Types of closures used for the ster
Page 111 and 112: Paper Code: BPP-417Pharmaceutics -X
Page 113 and 114: Paper Code: BPP-421Pharmacology-IV
Page 119 and 120: Paper Code: BPL-406Pharmaceutics -X
Page 121 and 122: Paper Code: BPL-408Pharmacology-V (
Page 123 and 124: Paper Code: BPL-410Pharmacology-VI
Page 127 and 128: Paper Code: BPP-416Pharmaceutics -X
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