Ordinance and Syllabus - Bhagat Phool Singh Mahila ...

Paper Code: BPL-302Pharmaceutical Chemistry-VIII (Medicinal Chemistry-I)L -- T -- P Total Credits: 044 -- -- Total Marks: 100External Marks: 50Internal Marks: 50Paper Objectives:Objective of this subject is to understand the Basic Principles of Medicinal Chemistry& modern approaches for drug designing. Paper also covers synthetic procedures,mode of action, uses, structure activity relationship including physicochemicalproperties of some classes of drugs.UNIT IBasic Principles of Medicinal Chemistry: Physico-chemical aspects (Optical,geometric and bio-isosterism) of drug molecules and biological action, Drug-receptorinteraction including transduction mechanisms.Principles of Drug Design (Theoretical Aspects): Traditional analog (QSAR) andmechanism based approaches (Introduction of graph theory, applications of quantummechanics, Computer Aided Drug Designing (CADD) and molecular modeling.UNIT IISynthetic procedures of selected drugs, mode of action, uses, structure activityrelationship including physicochemical properties of the drugs acting at Synapticand neuro-effector junction sites:Cholinergics and Anticholinesterases.Adrenergic drugs.Antispasmodic and anti ulcer drugs.Neuromuscular blocking agents.UNIT IIISynthetic procedures of selected drugs, mode of action, uses, structure activityrelationship including physicochemical properties of the following classes ofdrugs:Antihistamines.Eicosanoids.Analgesic-antipyretics, anti-inflammatory (non-steroidal) agents.Drugs affecting uterine motility: Oxytocics (including oxytocin, ergot alkaloids andprostaglandins).Biochemical approaches in drug designing wherever applicable should be discussed.UNIT IV Synthetic procedures of following selected drugs: Adrenaline, Phenylephrine,Edorphonium Chloride, Dicyclomine, Neostigmine bromide, Cyclopentolate HCl,92