Ordinance and Syllabus - Bhagat Phool Singh Mahila ...

Paper Code: BPL-301 Pharmaceutical Chemistry-VII (Pharmaceutical Analysis-II)L -- T -- P Total Credits: 044 -- -- Total Marks: 100External Marks: 50Internal Marks: 50Paper Objectives:Study of this subject gives knowledge about different techniques used for the estimation ofdrugs. Students are given the basic knowledge regarding the components of these techniques.It includes the study of column, thin layer, gas-liquid chromatography, HPLC and GC-MS,potentiometry, polarography, radiochemical techniques and differential scanningcolorimetry.UNIT I Electrochemistry: The electric cell, electrode potential, half cells, types of half cells,sign convention, Nernst equation, the salt bridge, activity series, standard potential,standard hydrogen electrode, measuring the relative voltage of half cells, calculationsof standard potential, reference electrodes, indicator electrodes. Potentiometry: Theoretical considerations, ion-selective electrodes, measurement ofpotential, location of end point equipment, analytical application, direct measurementof a metal concentration, differential curve, determination of ksp, pH measurementdead-stop titrations; pH meter, pH definition, relation to pH to potential, equipmentand applications. Conductometry: Conductometric titrations and their applications.UNIT IIPolarography and its applications: theory of mass transport processes, currentprocesses, current potential relationship, polarization, choice of electrodes, effect ofoxygen, instrumentation, calculation of concentration, laboratory design and safety.Amperometric tirations and its applications.Coulometry: Coulometric titrations, its principles and applications, controlledpotential coulometry, cell design, instrumentation, advantages and limitations, andelectrode selection.Extraction: Extraction procedure, separation of drug from Excipients, liquid-liquidextraction, separation of mixtures by extraction, distribution law, successiveextraction, the Craig method of multiple extraction, continuous counter-currentextraction, effect of temperature, pH, inert solute, association, ion-pair formation, theemulsion problem in extraction.UNIT III Fundamentals of Chromatography: Introduction and theory of underlying differenttypes of chromatography techniques like- Column chromatography, thin layerchromatography, paper and circular chromatography, adsorbents and solvents used inthese techniques. TLC: TLC in quantitative estimation.75