Metabolism of Ammonia <strong>and</strong> Nitrogen Containing Monomers: Nitrogen balance.Biosynthesis of amino acids. Catabolism of amino acids. Conversion of amino acidsto specialized products, Assimilation of ammonia. Urea. cycle, metabolic disorders ofurea cycle. Metabolism of sulphur containing amino acids. Porphyrin biosynthesis.formation of bile pigments. hyperbilirubinemia. Purine biosynthesis. Purinenucleotide interconversion. Pyrimidine biosynthesis. <strong>and</strong> Formation ofdeoxyribounucleotides.UNIT IVBiosynthesis of Nucleic Acids: Brief introduction of genetic organization of themammalian genome, alteration <strong>and</strong> rearrangements of genetic material, Biosynthesisof DNA <strong>and</strong> its replication. Mutation. Physical & chemical mutagenesis /carcinogenesis. DNA repair mechanism. Biosynthesis of RNA.Genetic Code <strong>and</strong> Protein Synthesis: Genetic code. Components of proteinsynthesis. <strong>and</strong> Inhibition of protein synthesis. Brief account of genetic engineering<strong>and</strong> polymerase chain reactions.Regulation of gene expression.Note: Instruction for Examiner:The Semester examination in each theory subject shall be of 50 marks. The examiner will setnine questions. Student will attempt five questions. First question would be of short answertype question covering all four Units (2.5 Marks per Unit) & it would be compulsory. Twoquestions will be set from each unit & out of which c<strong>and</strong>idate will attempt one question. EachQuestion shall be of 10 marks.Suggested Readings (Latest Editions):1. “Harper’s Review of Biochemistry”, California: Lange Medical Publications.2. A. L. Lehninger, “Principles of Biochemistry”, New Delhi: CBS Publishers.3. L. Stryer, “An Introduction to Biochemsitry”, San Francisco: Freeman <strong>and</strong> Company.4. B. Harrow <strong>and</strong> A. Mazur, “Textbook of Biochemistry”, Philadelphia: W. B. SaundersCompany5. E. E. Conn <strong>and</strong> P. K. Stumpf, “Outlines of Biochemistry”, New York: Jone Wiley &Sons.62
Paper Code: BPL-204Pharmaceutical Chemistry-VI (Organic Chemistry-II)L -- T -- P Total Credits: 044 -- -- Total Marks: 100External Marks: 50Internal Marks: 50Paper Objectives: The area of application of Organic Chemistry is vast <strong>and</strong> includesPharmaceuticals. The objective of the paper is to review <strong>and</strong> study fundamentals of OrganicChemistry in identifying <strong>and</strong> synthesizing organic compounds essentially employed as drugs<strong>and</strong> pharmaceuticals. By studying this subject, the students usually underst<strong>and</strong> differentorganic reactions <strong>and</strong> their mechanisms. Knowledge about different organic molecules, theiruse in pharmacy <strong>and</strong> basic Terms <strong>and</strong> techniques in organic chemistry are highlighted.UNIT I: Heterocyclic compounds:UNIT IIStudy of fundamentals of heterocyclic compounds, nomenclature, method of synthesis<strong>and</strong> important chemical reactions of the following: Five membered Heterocycles:Furan, Thiophene, Pyrrole, Thiazole, oxazole, imidazole, Pyrazole. Six memberedHeterocycles: Pyridine, pyridazine, Pyrimidine, Pyrazine, Pyrones. Benz-fusedHeterocycles: Quinoline, Isoquinoline, Indole.Carbohydrates: An account of the chemistry of Arabonose, Ribose, mannose,Glucose, fructose, Sucrose, Lactose, Cellulose, starch, Glycogen <strong>and</strong> dextrans,Structure elucidation of glucose, sucrose, starch.Lipids: Study of chemistry of fixed oils, fats <strong>and</strong> waxes.UNIT IIIProteins <strong>and</strong> Amino Acids: Isolation <strong>and</strong> general methods of synthesis of aminoacids <strong>and</strong> physico-chemical properties. General classification of proteins <strong>and</strong> endgroup analysis.Structural features of DNA <strong>and</strong> RNA.UNIT IVα,β-Unsaturated carbonyl compounds.Electrocyclic, Cycloaddition <strong>and</strong>sigmatropic reactions.Neighbouring group effects.Catalysis by transition metal complexes.Stereoselective <strong>and</strong> stereospecific reactions.63
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UNIT IVAnti-epileptics drugs.Anti-P
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Types of closures used for the ster
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Suggested Readings (Latest Editions
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Suggested Readings (Latest Editions
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Paper Code: BPP-421Pharmacology-IV
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Paper Code: BPL-402Pharmaceutical C
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Paper Code: BPL-404Pharmaceutical C
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