Ordinance and Syllabus - Bhagat Phool Singh Mahila ...

Paper Code: BPL-202Pharmaceutical Chemistry-V (Pharmaceutical Biochemistry)L -- T -- P Total Credits: 044 -- -- Total Marks: 100External Marks: 50Internal Marks: 50Paper Objectives: Students are taught those areas of biochemistry which are important forthe understanding of metabolic disorders relevant to common disturbances of body functions,gene structure and functions. General introduction and basic biochemistry of proteins,carbohydrates, bioenergetics, lipids, etc., including biochemistry of enzymes and metabolicfate of nitrogen is also taught. The syllabus also includes replication and expression ofgenetic information. Metabolic basis of biochemistry in relation to human metabolism,digestion and intestinal absorption are also taught.UNIT IIntroduction: Biochemical organization of the cell and transport processes across cellmembrane.The concept of free energy, determination of change in free energy - fromequilibrium constant and reduction potential, bioenergetics, production of A TP andits biological significance.Enzymes: Nomenclature, enzyme kinetics and its mechanism of action, mechanismof inhibition, enzymes and iso-enzymes in clinical diagnosis, immobilization ofenzymes. Co-enzymes: Vitamins as co-enzymes and their significance. Metals as coenzymesand their significance.Carbohydrate Metabolism: Conversion of polysaccharide to glucose-I-phosphate,Glycolysis and fermentation and their regulation, Gluconeogenesis andglycogenolysis, Metabolism of galactose and galactosemia, Role of sugar nucleotidesin biosynthesis, and Pentosephosphate pathway.UNIT IIThe Citric Acid Cycle: Significance, reactions and energetic of the cycle,Amphibolic role of the cycle, and Glyoxalic acid cycle.Lipids Metabolism: Oxidation of fatty acids, oxidation & energetic, β-oxidation,Biosynthesis of ketone bodies and their utilization. Biosynthesis of saturated andunsaturated fatty acids, Control of lipid metabolism, Essential fatty acids &eicosanoids (prostaglandins, thromboxanes and leukotrienes), phospholipids, andsphingolipids.Biological Oxidation : Redox-potential, enzymes and co-enzymes involved inoxidation reduction & its control, The respiratory chain, its role in energy capture andits control, Energetics of oxidative phosphorylation, Inhibitors of respiratory chainand oxidative phosphorylation, Mechanism of oxidative phosphorylation.UNIT IIINitrogen & Sulphur Cycle: Nitrogen fixation. ammonia assimilation, nitrificationand nitrate assimilation, Sulphate activation. sulphate reduction. Incorporation ofsulphur in organic compounds, Release of sulphur from organic compounds.61