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Ordinance and Syllabus - Bhagat Phool Singh Mahila ...

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Paper Code: BPL-406Pharmaceutics –XI (BioPharmaceutics & Pharmacokinetics)L -- T -- P Total Credits: 044 -- -- Total Marks: 100External Marks: 50Internal Marks: 50Paper Objective:The concepts of bioavailability <strong>and</strong> administration, absorption, distribution, metabolism <strong>and</strong>excretion of drugs are required to study the drug pharmacokinetic parameters, dosage regimedesign, therapeutic drug monitoring, in-vivo evaluation of drugs <strong>and</strong> bioavailability studies.Also the studies relating for population pharmacokinetics, determination of frequency,duration <strong>and</strong> quantity of drugs given for particular disease <strong>and</strong> schedule of drugs in variousailments & in different age groups.UNIT IIntroduction to Biopharmaceutics <strong>and</strong> Pharmacokinetics <strong>and</strong> their role in formulationdevelopment <strong>and</strong> clinical setting.Biopharmaceutics: Passage of drug across biological barrier (passive diffusion, activetransport, facilitated diffusion <strong>and</strong> pinocytosis).Factors influencing absorption: Physiochemical, physiological <strong>and</strong> pharmaceutical.Drug distribution in the body, plasma protein binding.UNIT II Pharmacokinetics, Significance of plasma drug concentration measurement,Compartmental model: definition <strong>and</strong> scope. Pharmacokinetics of drug absorption: Zero order <strong>and</strong> first order absorption rateconstant using wagner-Nelson <strong>and</strong> Loo-Riegelman method. Volume of distribution<strong>and</strong> distribution coefficient. Compartment kinetics: One compartment <strong>and</strong> two compartment models.Determination of pharmacokinetics parameters from plasma <strong>and</strong> urine data after drugadministration by intravascular <strong>and</strong> oral route.UNIT IIICurve fitting (method of residuals), regression procedures. Clearance concept,mechanism of renal clearance, clearance ratio, determination of renal clearance.Hepatic elimination of drugs, first pass effect, extraction ratio, hepatic clearance,billiary excretion, enterohepatic circulation.Non-linear pharmacokinetics with special reference to one compartment model afterI.V. drug administration, Michales Menten equation, determination of non-linearity(saturation mechanism).UNIT IVDosage regimen adjustment for repeated therapy.Clinical pharmacokinetics: Definition <strong>and</strong> scope, Dosage adjustment in patients with<strong>and</strong> without renal <strong>and</strong> hepatic failure.129

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