Note: Instruction for Examiner:The Semester examination in each theory subject shall be of 50 marks. The examiner will setnine questions. Student will attempt five questions. First question would be of short answertype question covering all four Units (2.5 Marks per Unit) & it would be compulsory. Twoquestions will be set from each unit & out of which c<strong>and</strong>idate will attempt one question. EachQuestion shall be of 10 marks.Suggested Readings (Latest Editions):1. William Kemp, “Organic Spectroscopy”, London: Macmillan Press Ltd.2. Willard, Merritt, Dean <strong>and</strong> Settle, “Instrumental Method of Analysis”, New Delhi:CBS Publishers.3. K. A. Conners, “A Textbook of Pharmaceutical Analysis”, New York: WileyInterscience.4. Silverstein et al., “Spectrometric Identification of Organic Compounds”, UnitedKingdom: John Wiley.5. Skoog, “Fundamental of Analytical Chemistry”, New York: Saunders CollegePublishing.6. John R. Dyer, “Applications of Absorption Spectroscopy of Organic Compounds”,New Delhi: Prentice Hall.128
Paper Code: BPL-406Pharmaceutics –XI (BioPharmaceutics & Pharmacokinetics)L -- T -- P Total Credits: 044 -- -- Total Marks: 100External Marks: 50Internal Marks: 50Paper Objective:The concepts of bioavailability <strong>and</strong> administration, absorption, distribution, metabolism <strong>and</strong>excretion of drugs are required to study the drug pharmacokinetic parameters, dosage regimedesign, therapeutic drug monitoring, in-vivo evaluation of drugs <strong>and</strong> bioavailability studies.Also the studies relating for population pharmacokinetics, determination of frequency,duration <strong>and</strong> quantity of drugs given for particular disease <strong>and</strong> schedule of drugs in variousailments & in different age groups.UNIT IIntroduction to Biopharmaceutics <strong>and</strong> Pharmacokinetics <strong>and</strong> their role in formulationdevelopment <strong>and</strong> clinical setting.Biopharmaceutics: Passage of drug across biological barrier (passive diffusion, activetransport, facilitated diffusion <strong>and</strong> pinocytosis).Factors influencing absorption: Physiochemical, physiological <strong>and</strong> pharmaceutical.Drug distribution in the body, plasma protein binding.UNIT II Pharmacokinetics, Significance of plasma drug concentration measurement,Compartmental model: definition <strong>and</strong> scope. Pharmacokinetics of drug absorption: Zero order <strong>and</strong> first order absorption rateconstant using wagner-Nelson <strong>and</strong> Loo-Riegelman method. Volume of distribution<strong>and</strong> distribution coefficient. Compartment kinetics: One compartment <strong>and</strong> two compartment models.Determination of pharmacokinetics parameters from plasma <strong>and</strong> urine data after drugadministration by intravascular <strong>and</strong> oral route.UNIT IIICurve fitting (method of residuals), regression procedures. Clearance concept,mechanism of renal clearance, clearance ratio, determination of renal clearance.Hepatic elimination of drugs, first pass effect, extraction ratio, hepatic clearance,billiary excretion, enterohepatic circulation.Non-linear pharmacokinetics with special reference to one compartment model afterI.V. drug administration, Michales Menten equation, determination of non-linearity(saturation mechanism).UNIT IVDosage regimen adjustment for repeated therapy.Clinical pharmacokinetics: Definition <strong>and</strong> scope, Dosage adjustment in patients with<strong>and</strong> without renal <strong>and</strong> hepatic failure.129
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7.2 The examination in each semeste
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10. Promotion:11. Division:WhereCi
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16. General Guidelines:16.1 Where t
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Drug chargesPre-packagingCentral st
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Note: Instruction for Examiner:The
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Autonomic nervous system: Physiolog
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Paper Code: BPL-107 REMEDIAL BIOLOG
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Paper Code: BPP-113Pharmaceutical C
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Paper Code: BPP-117REMEDIAL BIOLOGY
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products i.e. PVP, Dextran, absorba
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Note: Instruction for Examiner:The
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Note: Instruction for Examiner:The
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Paper Code: BPP-112 Pharmaceutical
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Paper Code: BPP-116 Pharmaceutical
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measurement, large-scale equipment
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UNIT IVComplexometric Titrations: C
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Pyridine-piperidine: tobacco, areca
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Note: Instruction for Examiner:The
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nuclear hazards, Solid waste manage
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NOTE:Types of listeningStrategies f
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Paper Code: BPP-213 Pharmaceutical
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Paper Code: BPL-202Pharmaceutical C
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Paper Code: BPL-204Pharmaceutical C
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Paper Code: BPL-206Pharmaceutics-V
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Paper Code: BPL-208Computer Science
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Paper Code: BPL-210Pharmaceutical M
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Paper Code: BPP-212Pharmaceutical C
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Paper Code: BPP-216Pharmaceutics-V
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Paper Code: BPL-301 Pharmaceutical
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