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Ordinance and Syllabus - Bhagat Phool Singh Mahila ...

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Paper Code: BPL-402Pharmaceutical Chemistry-X (Medicinal Chemistry-III)L -- T -- P Total Credits: 044 -- -- Total Marks: 100External Marks: 50Internal Marks: 50Paper Objectives: Medicinal chemistry is a branch of chemistry also involving aspects ofbiological, medical <strong>and</strong> pharmaceutical sciences. It is concerned with the invention,discovery, design, identification <strong>and</strong> preparation of biologically active compounds, theinterpretation of their mode of interaction at the molecular level, the construction of theirstructure-activity relationships, <strong>and</strong> study of their metabolism.UNIT IDrug metabolism <strong>and</strong> Concepts of Prodrugs.Synthetic procedures of selected drugs, mode of action, uses, structure activityrelationship (including physicochemical aspects) of the following classes of drugs.(Biochemical approaches in drug designing wherever applicable should be discussed):Antineoplastic agents.UNIT IIAntimetabolites (including sulfonamides).Chemotherapeutic agents used in Protozoal, Parasitic <strong>and</strong> other infectionAnti-viral including anti - HIVagents.Immunosuppressives <strong>and</strong> immunostimulants.UNIT IIIAmino acids, peptide, nucleotides <strong>and</strong> related drugs:Thyroid <strong>and</strong> Anti thyroid drugsInsulin <strong>and</strong> oral hypoglycemic agents.Peptidomimetics <strong>and</strong> nucleotidomimetics.Diagnostic agents.Pharmaceutical Aids.UNIT IV Synthetic procedures of following selected drugs: Diethyl carbamazine,Thiabendazole, Sulphadiazine, Sulphamethoxazole, Trimethoprim,Cycloserine,Chloramphenicol, Nalidixic acid, Norfloxacin, Nitorfurantoin, Isoniazid, Ethambutol,Ethonamide, Clofazimine, Ketoconazole, Clotrimazole, Chlorambucil, Melphalan,Thio-TEPA, 5-Fluorouracil, Cisplatin, Tolbutamide, Rosiglitazone, Pioglitazone, L-Thyroxine, Methylthiouracil, Methimazole, Azathioprone, Primaquine, Amodiaquine,Pyrimethamine, Metronidazole, Thioacetazole, Pyrazinamide.125

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