Annual Report - Mental Health Research Institute
Annual Report - Mental Health Research Institute
Annual Report - Mental Health Research Institute
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2010<br />
<strong>Annual</strong> <strong>Report</strong><br />
<strong>Mental</strong> <strong>Health</strong><br />
<strong>Research</strong> <strong>Institute</strong><br />
Image: Microscopic image of a human cerebrum
Vision<br />
To be a global leader in research that improves the lives of people affected<br />
by mental illness including psychotic illness (schizophrenia and depression)<br />
and neurodegenerative diseases (dementia and Alzheimer’s disease).<br />
Mission<br />
• To undertake sustainable, high quality, basic scientific, clinical and public<br />
health research<br />
• To promote understanding of, and investment in, research through advocacy<br />
• To educate clinicians and researchers<br />
• To provide expert commentary on the scientific basis of mental/psychiatric<br />
illness and dementia<br />
Structure<br />
The <strong>Institute</strong> is governed by a Board which is legally responsible for ensuring<br />
that the <strong>Institute</strong>’s work is directed towards its stated objectives. This Board<br />
comprises the Deans from the Medical Faculties of Monash University and<br />
The University of Melbourne, the <strong>Institute</strong>’s Executive Director, and up to 12<br />
other voluntary members.<br />
The <strong>Institute</strong> is formally affiliated with The University of Melbourne, Monash<br />
University and Melbourne <strong>Health</strong>.<br />
2010 was Linh Lam’s second year working as a research assistant at MHRI. She joined the <strong>Institute</strong> after completing<br />
her honours year and now works on cell culture, histology, APP purification, animal work, molecular biology and<br />
other laboratory duties. <strong>Research</strong> assistants provide essential support to senior scientists. Linh enjoys the friendly<br />
atmosphere and colleagues she works with at MHRI, as well as the contribution she can make to society.<br />
The image Linh holds shows alpha-synuclein, a protein thought to aggregate in Parkinson’s disease.
Contents<br />
4 Board of Directors<br />
8 Chair’s <strong>Report</strong><br />
10 Executive Director’s <strong>Report</strong><br />
14 Rebecca L Cooper Laboratory<br />
18 Behavioural Neuroscience Laboratory<br />
22 Molecular Psychopharmacology /<br />
Northern Psychiatry <strong>Research</strong> Centre<br />
25 Neuropathology Laboratory<br />
26 Oxidation Biology Laboratory<br />
29 Synaptic Neurobiology Laboratory<br />
30 Clinical <strong>Research</strong> Group<br />
34 Clinical Discovery Unit<br />
36 Victorian Brain Bank Network<br />
38 Psychotropic Drug Advisory Service<br />
41 The Dax Centre<br />
44 Development and Communications<br />
48 Publications<br />
56 Financials<br />
87 Personnel<br />
95 Donations (Thank you)<br />
111 Further Information
4<br />
Board of Directors<br />
CHAIR – Dr Sandra Hacker AO<br />
MBBS, DPM, FRANZCP, FAICD<br />
Sandra Hacker is a psychiatrist. She works in private practice and as Liaison Psychiatrist at the Heart/Lung<br />
Transplant Unit. She is Chair of the Australian <strong>Health</strong> Ethics Committee of the National <strong>Health</strong> and Medical<br />
<strong>Research</strong> Council and a Director of the Dax Centre.<br />
Dr Hacker was appointed to the MHRI Board in 2000 and became Chair in 2008. She is Chair of the<br />
<strong>Institute</strong>’s Policy and Human Resources and Nomination Committees, and a member of the Audit and Risk<br />
Management Committee.<br />
DEPUTY CHAIRMAN – Mr Trevor Clark OAM<br />
ACIS, FAMI, FAICD, CPM<br />
Trevor Clark is the Director of management consultancy, TM Clark & Associates. He has been awarded<br />
a Medal of the Order of Australia, recognising his outstanding contribution to the community.<br />
Mr Clark was appointed to the MHRI Board in 1998 and became Deputy Chair in 2002. He is Chair of the<br />
<strong>Institute</strong>’s Development Council and a member of the Policy and Human Resources<br />
and Nomination Committees.<br />
EXECUTIVE DIRECTOR – Laureate Professor Colin Masters<br />
BMedSc (Hons), MBBS, MD, Hon DLitt WAust, FRCPath, FRCPA, FAA, FTSE<br />
Colin Masters is a Laureate Professor at The University of Melbourne and a former Director of Prana<br />
Biotechnology. He is one of the world’s best known authorities on Alzheimer’s disease.<br />
Professor Masters was appointed as the <strong>Institute</strong>’s Executive Director in 2007. He is an ex officio member<br />
of the <strong>Institute</strong>’s Audit and Risk Management, Policy and Human Resources, Intellectual Property and<br />
Commercialisation, and Scientific Advisory Committees.<br />
Images (from left to right): Dr Sandra Hacker AO | Mr Trevor Clark OAM | Laureate Professor Colin Masters
Professor James Angus AO<br />
BSc, PhD, FAA<br />
James Angus is Dean of the Faculty of Medicine, Dentistry and <strong>Health</strong> Sciences at The University of<br />
Melbourne. He is also a Fellow and former Member of Council at the Australian Academy of Science.<br />
Professor Angus was appointed to the MHRI Board in 2003. He is Chairman of the <strong>Institute</strong>’s Scientific<br />
Advisory Committee and a member of the Nominations Committee.<br />
Mr Rob Gerrand<br />
BA, FAMI, FAICD<br />
Rob Gerrand heads the marketing and communications consultancy Gerrand & Associates. He is also<br />
Chair of Parks Victoria, a Director of Alfred <strong>Health</strong> and Chair of <strong>Health</strong>y Parks <strong>Health</strong>y People Global Ltd.<br />
He is a former General Manager of Group Public Affairs at ANZ. Previous board appointments include the<br />
Financial Planning Association of Australia, the Koorie Heritage Trust and the Melbourne Convention and<br />
Marketing Bureau. He was the Founding President of the Monash Alumni Association, and in 1994 was<br />
appointed Adjunct Professor at Deakin University. He is a published author.<br />
Mr Gerrand was appointed to the MHRI Board in 1995 and is a member of the Audit and Risk Management<br />
Committee. He is a member of the <strong>Institute</strong>’s Development Council and represents the MHRI Board on the<br />
Project Committee of the Melbourne Neuroscience Project.<br />
Ms Jennifer Labourne<br />
BBus, FCPA<br />
Ms Labourne was Deputy Chair of <strong>Health</strong> Purchasing Victoria, is a member of the Board of Parks Victoria<br />
and Director of Finance & Business Services at Colac Area <strong>Health</strong>. She was previously a partner at Ernst<br />
& Young and has been involved on various committees of the Australian Society of Certified Practicing<br />
Accountants (CPAs).<br />
Jennifer Labourne was appointed to the MHRI Board in 2007. She is Chair of the <strong>Institute</strong>’s Audit and Risk<br />
Management Committee.<br />
Images (from left to right): Professor James Angus AO | Mr Rob Gerrand | Ms Jennifer Labourne<br />
5
6<br />
Board of Directors<br />
continued<br />
Mr Andrew Stripp<br />
MSc (Clin Psychol), BBSc(Hons)<br />
Andrew Stripp is the Deputy Chief Executive Officer at Alfred <strong>Health</strong>. Previous roles include Director,<br />
Strategic Projects, Department of Human Services (DHS) and Director, Southern Metropolitan Region (DHS).<br />
Mr Stripp was appointed to the MHRI Board in July 2009.<br />
Professor Steve Wesselingh<br />
MBBS, FRACP, PhD<br />
Professor Steve Wesselingh is Dean of the Faculty of Medicine, Nursing and <strong>Health</strong> Sciences at Monash<br />
University. Prior to taking up the Deanship in 2007, Professor Wesselingh was Director of the Burnet <strong>Institute</strong>.<br />
From 1994 to 1997 he was on the Board of the Australian Society for Medical <strong>Research</strong> (ASMR), acting as<br />
President in 1998. He is recognised internationally as an expert in viruses that affect the human brain.<br />
He has held National <strong>Health</strong> and Medical <strong>Research</strong> Council (NHMRC) Program and Project Grants and<br />
also a number of National <strong>Institute</strong>s of <strong>Health</strong> (NIH, USA) and Australian <strong>Research</strong> Council (ARC) grants.<br />
Professor Wesselingh was appointed to the MHRI Board in 2007 and is a member of the Scientific<br />
Advisory Committee.<br />
Professor Ingrid Winship<br />
MBChB, MD, FRACP, FACD<br />
Ingrid Winship is Professor of Adult Clinical Genetics at The University of Melbourne and Executive Director<br />
of <strong>Research</strong>, Melbourne <strong>Health</strong>. Previous appointments include Head, Adult and Cancer Genetics,<br />
Genetic <strong>Health</strong> Services Victoria (2004-2006) and Associate Dean, <strong>Research</strong>, Faculty of Medical and<br />
<strong>Health</strong> Sciences, University of Auckland (1999-2004) and Clinical Director, Northern Regional Genetic<br />
Service, Auckland District <strong>Health</strong> Board (1994-2004).<br />
Professor Winship was appointed to the MHRI Board in June 2009.<br />
Images (from left to right): Mr Andrew Stripp | Professor Steve Wesselingh | Professor Ingrid Winship
Development Council<br />
The <strong>Institute</strong>’s Development Council supports<br />
the <strong>Institute</strong>’s fundraising activities.<br />
Chairman, Trevor Clark OAM<br />
Peter Bennell<br />
David Dean<br />
Rob Gerrand<br />
Doug George AM<br />
Ian Farrington<br />
Roger Flynn<br />
Geoff Marshall<br />
George McMaster<br />
Jenny Mills<br />
Martin Ryan<br />
Scientific Advisory Committee<br />
Chairman, Professor James Angus<br />
Professor Steve Wesselingh<br />
Professor Sam Berkovic<br />
Professor John Furness<br />
Professor Bruce Tonge<br />
Professor Assen Jablensky<br />
Professor Tony Burgess<br />
Professor Colin Masters (ex officio)<br />
Organisational Memberships<br />
Australian Association of<br />
Medical <strong>Research</strong> <strong>Institute</strong>s<br />
(AAMRI - includes The Australian Synchrotron)<br />
Australia Israel Chamber of Commerce<br />
BioMelbourne Network<br />
Bio21<br />
<strong>Mental</strong> <strong>Health</strong> Council of Australia<br />
<strong>Mental</strong> Illness Fellowship of Victoria<br />
National Neuroscience Facility<br />
Neurosciences Victoria<br />
<strong>Research</strong> Australia<br />
<strong>Annual</strong> General Meeting<br />
The <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong>’s <strong>Annual</strong><br />
General Meeting will be held on 19th May, 2011.<br />
7
8<br />
Chair’s <strong>Report</strong><br />
Dr Sandra Hacker AO<br />
It has been a busy and exciting year implementing our strategic plan to support our vision to be a<br />
global leader in research that improves the lives of people affected by mental illness.<br />
Critical to our strategic plan was the need to develop and raise the profile of our brand. To address this,<br />
the Board decided that our corporate image should be updated. A new logo was adopted to represent<br />
the progressive nature of the <strong>Institute</strong>, which is at the forefront of mental illness research.<br />
The logo represents a modern day puzzle. A dislodged blue piece symbolises the solution that we strive<br />
to find each day through our research, which will enable better diagnosis, treatment and, ideally, the<br />
prevention of mental illness. The colours chosen for our new corporate logo are friendly and soothing for<br />
our many stakeholders who face the day to day turmoil of living with, or caring for someone who has a<br />
mental illness.<br />
The Melbourne Neuroscience Project continued to keep us busy throughout the year. Completion of the<br />
Austin facility is expected in early 2011 and the Parkville facility in mid 2011. These two facilities, along<br />
with a Centre for Translational Neuroscience at the Royal Melbourne Hospital, have been named the<br />
Melbourne Brain Centre. Much work is under way to ensure equipment is in place so that our researchers<br />
can continue their important work immediately on re-location. We look forward to celebrating the opening<br />
of these two buildings in 2011.<br />
Over the last eighteen months we have seen a number of Directors leave the board. We thank Jennifer<br />
Williams and Katarina Klaric for their hard work over the years. In particular, we owe great thanks to<br />
Professor Gad Trevaks who worked tirelessly for the <strong>Institute</strong> over a great many years. As recent additions to<br />
the Board we welcome Professor Ingrid Winship, Executive Director of <strong>Research</strong> at Melbourne <strong>Health</strong> and<br />
Mr Andrew Stripp, Deputy Chief Executive Officer at the Alfred Hospital.<br />
The tireless efforts of our Development Council have resulted in $1.34 million being raised this year to<br />
support the <strong>Institute</strong>’s activities. In addition, they have been focusing on the establishment of some<br />
exciting new fundraising events. A highlight will be a culinary event at Crown Entertainment Centre that<br />
will see teams led by Shannon Bennett of Vue de Monde in Melbourne and Matt Moran of ARIA in Sydney<br />
battle it out to prove once and for all which city has the best food.<br />
Once again, we must thank the Victorian State Government who offer continued support through both<br />
the Department of <strong>Health</strong> and the Department of Innovation, Industry and Regional Development who<br />
provide both recurrent and project grants including Operational Infrastructure Support.<br />
Dr Sandra Hacker AO
The image Dr Hacker holds shows how Purkinje cells (the large cell bodies) are typically arranged in a<br />
single row at the junction of the molecular and granular layers of the cerebellum 9
10<br />
Executive Director’s <strong>Report</strong><br />
Professor Colin L. Masters MD<br />
The highlight of 2010 has been the commitment by the Federal Government’s Cooperative <strong>Research</strong><br />
Centre (CRC) Program to advance Australia’s research efforts in the area of <strong>Mental</strong> <strong>Health</strong>. The <strong>Mental</strong><br />
<strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> (MHRI) successfully led a bid that attracted $23 million to establish the CRC<br />
for <strong>Mental</strong> <strong>Health</strong> with partners including CSIRO, Pfizer, Mercy <strong>Health</strong>, Edith Cowan University, Hall & Prior<br />
and the McCusker Foundation.<br />
The CRC for <strong>Mental</strong> <strong>Health</strong> will conduct research to identify and develop biomarkers for the diagnosis of<br />
various mental illnesses and develop new and more effective therapeutics for their treatment. Another $27<br />
million was awarded to a group including our neighbours, Orygen Youth <strong>Health</strong>, to focus on youth mental<br />
health issues.<br />
This unprecedented amount of funding for mental health research will provide a much needed boost to<br />
further our research activities and gain a better understanding of mental illnesses including Alzheimer’s<br />
disease, Parkinson’s disease and psychotic illness such as schizophrenia and mood disorders.<br />
The CRC for <strong>Mental</strong> <strong>Health</strong> will be based on the successful Australian Imaging, Biomarkers and Lifestyle<br />
(AIBL) study, a clinical cohort established to predict early signs of Alzheimer’s disease, with similar cohorts<br />
being established to assist with studies into psychoses and Parkinson’s disease.<br />
The AIBL study has continued to attract interest around the world. It has secured further funding from<br />
pharmaceutical companies and from CSIRO through the Science and Industry Endowment Fund. Such<br />
funding will ensure that the study continues for at least the next three years.<br />
Our Kearney Visiting Professor, Julie Anderson from California’s Buck <strong>Institute</strong>, gave the 17th <strong>Annual</strong> John<br />
Cade Lecture this year. Professor Anderson presented an interesting and well-attended public lecture on<br />
the role of iron in Parkinson’s disease and the development of new drugs to treat this debilitating disease.<br />
Professor Colin Masters holds an image of C. elegans as seen under a microscope. These worms offer a<br />
new research tool to model diseases of ageing and identify new drugs.
12<br />
Executive Director’s <strong>Report</strong><br />
continued<br />
A number of MHRI researchers have been recognised this year for their professional achievements including:<br />
• Professor Ashley Bush, who was among 28 leaders in technological science, engineering and innovation<br />
elected as Fellows of the Australian Academy of Technological Sciences and Engineering (ATSE) and<br />
was also joint recipient of The Royal Australian and New Zealand College of Psychiatrists’ Shering-Plough<br />
Senior <strong>Research</strong> Award, recognising excellence in research in psychiatry;<br />
• Dr Blaine Roberts and Dr James Duce, who received the new Young Investigator Award from the<br />
Bethlehem Griffiths <strong>Research</strong> Foundation;<br />
• Professor Michael Berk, who was Highly Commended for his Outstanding Individual Achievement in<br />
<strong>Mental</strong> <strong>Health</strong>care in the Victorian Public <strong>Health</strong>Care Awards;<br />
• Professor Catriona McLean, who was awarded the Crawford Mollison Prize by the AMA for ‘outstanding<br />
work’ in the field of Pathology in Victoria as well as the Noel Callahan Medal from the Irish Neurological<br />
Society. She also received the National Citation award for outstanding contribution to student learning from<br />
the Australian Learning and Teaching Council (ALTC) and an Honourable mention for the TAMSS Teaching<br />
Recognition award.<br />
During the year, Melbourne welcomed Professor Ian Everall to the position of Cato Professor of Psychiatry<br />
and Head of the Department of Psychiatry, The University of Melbourne. We have been working closely<br />
with Professor Everall since his arrival to coordinate neuropsychiatry research efforts and we look forward<br />
to continuing this important partnership in 2011.<br />
The year ahead will be very exciting as we finalise our plans for relocation to the new Parkville Facility of the<br />
Melbourne Brain Centre in October 2011. We are currently reviewing our equipment needs and completing<br />
space allocation in readiness for our move.<br />
We thank both the State and Commonwealth Governments for their assistance in providing purpose built<br />
facilities to house some of the world’s best neuroscientists from MHRI, The University of Melbourne and<br />
Florey Neuroscience <strong>Institute</strong>s.<br />
John and Lorraine Bates are generous donors to the <strong>Institute</strong>. We are grateful for their support and the<br />
wonderful support we receive from each of our donors. A full list of donors appears later in this report.<br />
The image being held by John and Lorraine is of a stain for iron accumulation in neurons within the brain.<br />
Colin L. Masters MD
14<br />
Rebecca L Cooper Laboratory<br />
Head: Professor Brian Dean<br />
The Rebecca L Cooper Laboratory aims to identify the molecular pathways that are affected by<br />
schizophrenia, bipolar disorder and major depressive disorders. Understanding the pathophysiology<br />
of these diseases will enable rationale-based drug design that targets the proteins or RNA involved in<br />
disease processes. Such drugs will improve the wellbeing of people who suffer from these debilitating<br />
disorders, many of whom do not achieve satisfactory outcomes from the treatments currently available.<br />
Highlights<br />
Identifying a subgroup within patients with schizophrenia<br />
Elizabeth Scarr and her colleagues in the Muscarinic Receptor Group continue to investigate why a<br />
sub-group has lost approximately 75% of their cortical muscarinic M1 receptors. This subgroup, identified by<br />
Elizabeth in 2009, comprises about 25% of all cases of schizophrenia within the Victorian Brain Bank Network.<br />
The group are comparing changes in the expression of all known genes in the brains of people in this<br />
subgroup to those of other people with schizophrenia who have not lost muscarinic receptors, as well as<br />
control subjects. This study will also compare gene expression in mice that do not have muscarinic M1<br />
receptors (through genetic engineering) to that in wild type mice.<br />
It appears that the different pathways are altered in the cortex of subjects with decreased levels of<br />
muscarinic receptors. This evidence strongly suggests that there are different biochemical causes of<br />
this form of schizophrenia, compared with the disorder affecting people who have not lost muscarinic<br />
receptors. This project is funded by the National <strong>Health</strong> and Medical <strong>Research</strong> Council (NHMRC).<br />
The group is now investigating pathways in the brain that are only altered in this subgroup. This will help<br />
elucidate the underlying cause of this form of schizophrenia, potentially revealing new ways to treat<br />
people who experience it.
Proinflammatory pathways and depression<br />
In 2009, the Rebecca L Cooper Laboratory was the first to show a 150% increase in transmembrane tumour<br />
necrosis factor in the cortex of subjects with depression; an increase not apparent in schizophrenia.<br />
Changes in the same protein have now been found in bipolar disorder as well.<br />
Since tumour necrosis factor is a central molecule in the proinflammatory pathways, this initially suggested<br />
that those pathways were affected in depression. However, new data suggest that changes in the brains of<br />
people with mood disorders are more likely to reflect a role for tumour necrosis factor in cell to cell signalling.<br />
Brian Dean and the team are now looking at the tumour necrosis factor driven pathways in mood<br />
disorders to understand how they can cause depression.<br />
Staff achievements<br />
Brian Dean’s NHMRC Fellowship was renewed and he was elected President of Biological Psychiatry<br />
Australia, President of the Melbourne Chapter of the Society of Neuroscience and Treasurer of Collegium<br />
Internationale Neuro-Psychopharmacologicum, the Worldwide Neuropsychopharmacology Society.<br />
Brian was also invited to address the announcement of the NHMRC Fellowship Program by the Honorable<br />
Mark Butler MP, Minister for <strong>Mental</strong> <strong>Health</strong> and Ageing.<br />
Elizabeth Scarr won an Australian <strong>Research</strong> Council (ARC) Future Fellowship, was a member of the<br />
Executive Committee of the Australian Society for Psychiatric <strong>Research</strong> and is a member of the Executive<br />
Committee of Biological Psychiatry Australia. Elizabeth was invited to the Ministerial announcement of the<br />
ARC Future Fellowship Program where she met Senator Kim Carr, Minister for Innovation, Industry, Science<br />
and <strong>Research</strong>.<br />
Myoung Suk Seo and Won Je Jeon won travel awards to the Second Asian Congress of Schizophrenia<br />
<strong>Research</strong> in Seoul, Korea.<br />
15
Rebecca L Cooper Laboratory<br />
continued<br />
Conferences & presentations<br />
Australian Society for Neuroscience, Sydney, Australia (January 2010)<br />
Schizophrenia <strong>Research</strong> Society Conference, Florence, Italy (April 2010)<br />
The CINP World Congress, Hong Kong (June 2010)<br />
Combio, Melbourne, Australia (October 2010)<br />
Society for Neuroscience, San Diego, USA (November 2010)<br />
<strong>Annual</strong> Meeting of the American College of Neuropsychopharmacology, Miami, USA (December 2010)<br />
Professor Brian Dean is head of the Rebecca L Cooper Laboratory and one of the longest serving researchers at the <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong>.<br />
He leads a group of scientists working to better understand what happens in the brain of people who suffer depression, bipolar disorder and schizophrenia.<br />
Much of his research utilises post-mortem brain tissue from the Victorian Brain Bank Network.<br />
The image Brian holds is from an imaging study showing muscarinic receptors in tissue samples from the brains of people with schizophrenia. The one on<br />
the right is from the subgroup identified by Brian’s team who have lost most of these receptors. 17
18<br />
Behavioural<br />
Neuroscience Laboratory<br />
Head: Associate Professor Maarten van den Buuse<br />
The Behavioural Neuroscience Laboratory uses behavioural animal models to study brain<br />
neurotransmitter mechanisms involved in schizophrenia. We use state-of-the-art automated equipment<br />
for in vivo experiments, including photocell activity meters, automated video analysis of behaviour,<br />
prepulse inhibition of startle and models of learning and memory in rodents. This in vivo work is<br />
complemented with human studies, receptor binding autoradiography, and molecular studies.<br />
Highlights<br />
Stress, BDNF and schizophrenia<br />
The ‘two-hit’ hypothesis of schizophrenia states that stress early in development increases vulnerability<br />
to later stressful events, leading to a higher risk of developing psychosis. Previous work in the laboratory<br />
established animal models to study this interaction and suggested an important role of the neurotrophic<br />
factor, BDNF.<br />
Maren Klug continued her PhD project to study the effects of neurodevelopmental stress in geneticallymodified<br />
mice that only produce about half of the normal levels of BDNF. These mice are being treated<br />
with stress hormone. The long-term effects of this combined genetic and treatment approach is<br />
characterised in a battery of behavioural tests, including learning and memory.<br />
Rachel Hill was instrumental in establishing neurochemical methods to assess the impact of<br />
neurodevelopmental stress on the brain, such as on BDNF levels and NMDA glutamate receptors.<br />
While Maren’s initial work was done on mice from a breeding colony at the <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong><br />
<strong>Institute</strong>, Sally Martin established a new breeding colony of these animals at the Florey Neuroscience<br />
<strong>Institute</strong>s which will facilitate the transition of this work into the new Melbourne Brain Centre in 2011.<br />
Elizabeth Manning commenced a PhD project looking at another aspect of this ‘two-hit’ model: chronic<br />
treatment with metamphetamine, which may induce psychosis in vulnerable individuals.<br />
Shane Thwaites also started a PhD project and established an EEG-based model of sensory gating<br />
in rats. Shane is currently assessing the effect of different acute and chronic treatments relevant to<br />
schizophrenia in this new animal model, which may become a valuable resource to investigate the effects<br />
of neurodevelopmental factors in schizophrenia-like behaviour.<br />
This work on neurodevelopmental stress and schizophrenia is supported by a Project Grant from the<br />
National <strong>Health</strong> and Medical <strong>Research</strong> Council (NHMRC).
Reelin and behaviour<br />
Paul Halley and Maaike Labots characterised behavioural changes in mice with a genetic deficit in reelin<br />
production. This protein plays an important role in brain development and its levels are reduced in the<br />
brains of patients with schizophrenia.<br />
Reelin heterozygous mice showed marked sex-specificity in their behavioural changes. Further studies<br />
by Jac Kee Low and Perrin Kwek demonstrated that removing the source of sex steroid hormones could<br />
influence the behavioural deficits seen in these mice, as studied in behavioural tests of psychosis-like<br />
behaviour and of sensory gating (the process by which the brain responds to external stimuli). The role<br />
of reelin in schizophrenia was the subject of a successful project application to the NHMRC enabling this<br />
work to continue in 2011.<br />
Sex steroid hormones and neurodevelopment<br />
Supported by a NHMRC Project Grant, Andrea Gogos and Perrin Kwek continued their pharmacological<br />
studies on how oestrogen and testosterone can modulate behaviour and central neurotransmitter activity.<br />
They published an extensive pharmacological study suggesting that oestrogen blocks disruption of<br />
prepulse inhibition by an action on the dopamine system in the brain. Prepulse inhibition is a model of<br />
sensory gating that is disrupted in schizophrenia. This effect of oestrogen was confirmed by receptor<br />
binding studies performed by Carolina Chavez and Marianne Hollaus, which showed changes in<br />
dopamine D2 receptor density and dopamine transporter density, but not several other neurotransmitter<br />
parameters, in rats which had different circulating levels of oestrogen.<br />
Rachel Hill continued her work on developmental aspects of sex steroid hormone involvement in<br />
behaviour. She published on enhanced levels of BDNF in the hippocampus of mice with a genetic<br />
deficit of the serotonin-2C receptor. She also demonstrated sex dependent and region-specific changes<br />
in the activity of the BDNF receptor, TrkB, in mice with a genetic deficit of BDNF production. Candy Wu<br />
commenced a PhD project and worked with Rachel to study the interaction of serotonin-1A receptor<br />
function and BDNF in mice. This work is expected to elucidate the interaction of BDNF and serotonin in<br />
developmental animal models of schizophrenia and depression.<br />
19
20<br />
Behavioural<br />
Neuroscience Laboratory<br />
continued<br />
Glutathione<br />
Levels of the endogenous radical scavenger, glutathione, are reduced in the brain in schizophrenia.<br />
In collaboration with Ashley Bush, Michael Berk and David Copolov, Olivia Dean and Chris Choy published<br />
research on an animal model of experimentally-induced glutathione depletion. Olivia described<br />
disruptions of prepulse inhibition regulation in these animals, whereas Chris Choy showed that a previously<br />
published deficit in short-term spatial memory could be reversed if the animals were treated with the<br />
glutathione precursor, N-acetyl-cysteine.<br />
These findings may help to understand the involvement of oxidative stress in schizophrenia and the<br />
mechanisms by which drugs that counteract oxidative stress may be clinically beneficial.<br />
Staff achievements<br />
Maarten van den Buuse organised, chaired and presented a symposia at the CINP Congress in Hong<br />
Kong, and at the Australasian Cognitive Neuroscience Conference in Melbourne.<br />
Wendy Adams was awarded her PhD at The University of Melbourne (thesis title: Investigating the role of<br />
serotonin in the hippocampus in schizophrenia: lesion studies in animal behavioural models) and is now<br />
pursuing postdoctoral studies at the University of British Columbia, Vancouver.<br />
Maaike Labots and Emma Ruimschotel completed internships (Honours equivalent) in the laboratory and<br />
obtained their degrees at Leiden University and the University for Applied Science, <strong>Institute</strong> for Life Sciences<br />
and Chemistry, Utrecht, The Netherlands, respectively. Jac Kee Low was awarded her BSc (Hons) degree at<br />
The University of Melbourne.<br />
Conferences & presentations<br />
Australasian Schizophrenia Conference, Sydney, Australia (September 2010)<br />
Serotonin Club meeting, Montreal, Canada (July 2010)<br />
Society for Neuroscience meeting, San Diego, USA (November 2010)<br />
Australian Neuroscience Society meeting, Sydney, Australia (January 2010)<br />
Australasian Cognitive Neuroscience Conference, Melbourne, Australia (November 2010)<br />
Collegium Internationale Neuro-Psychopharmacologicum Meeting, Hong Kong (July 2010)
John and Lorraine Bates have supported research at the <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> through regular donation for over 20 years. “MHRI does ground<br />
breaking research into mental illness” says John,“particularly schizophrenia, which is of great importance to us”. Because of the generosity of donors like John<br />
and Lorraine, the <strong>Institute</strong> can complete high risk pilot projects that can lead to new discoveries, and purchase equipment that can accelerate research progress.<br />
The image John and Lorraine hold shows a light micrograph of a section through the cerebellum of the brain.<br />
21
22<br />
Molecular Psychopharmacology /<br />
Northern Psychiatry <strong>Research</strong> Centre<br />
Head: Associate Professor Suresh Sundram<br />
The Molecular Psychopharmacology Laboratory is dedicated to understanding the molecular pathology of<br />
psychotic disorders such as schizophrenia and bipolar disorder. It aims to develop better and more effective<br />
markers and interventions for these illnesses. We do this by investigating how psychotropic medications and<br />
drugs interact with receptors and intracellular signalling mechanisms in nerve cells (neurons).<br />
The understanding gained from this work can then be tested in clinical populations through the Northern<br />
Psychiatry <strong>Research</strong> Centre (NPRC) leading to the development of new treatments and markers. Moreover,<br />
the NPRC can collect clinical material and biological samples that can be examined in the laboratory to<br />
better understand these disorders.<br />
Highlights<br />
Investigating how antipsychotic drugs work<br />
The mainstay of treatment for psychotic disorders including schizophrenia and bipolar disorder are<br />
antipsychotic drugs. These agents have been in use for over 50 years but we still have a limited<br />
understanding of how they work.<br />
The Molecular Psychopharmacology Laboratory has been working to understand why one antipsychotic<br />
drug, clozapine, is effective in people for whom other antipsychotic drugs are not. From this we hope to<br />
gain insight into the pathology of psychotic disorders and more effective ways of treating them.<br />
We have previously described a novel pathway of action where clozapine interacts with the epidermal<br />
growth factor (EGF) system to signal intracellularly to the mitogen activated protein kinase / extracellular<br />
signal regulated kinase (MAPK/ERK) cascade in brain cells. The EGF system has been implicated in the<br />
pathology of schizophrenia and is involved in regulating many cell and brain processes that may be<br />
disturbed in the illness.<br />
Avril Pereira and her team have subsequently been investigating which proteins are activated in the brain<br />
consequent to clozapine treatment. In collaboration with Peter Crouch, David Bowser and Anthony White<br />
from The University of Melbourne, this work received a three year NHMRC Project Grant commencing in<br />
2010. Two further papers have been submitted for publication.<br />
In parallel with the laboratory-based aspects of the project, Sujeevan Sinnatamby and the NPRC have<br />
been collecting clinical data and biological samples from people who are receiving treatment with<br />
clozapine. We will use these data to determine if there are specific genetic variants that can predict<br />
response to clozapine treatment. Biological samples are being collected with the help of funding from the<br />
Marian and EH Flack Trust.
The development of this type of screening test will<br />
help prevent unnecessary exposure to the toxic<br />
effects of clozapine for many people, and streamline<br />
potential responders to earlier and more effective<br />
intervention.<br />
This work has been sustained by the generous and<br />
ongoing support of One in Five to understand the<br />
pathology of schizophrenia and hopefully develop<br />
more effective interventions. Our preliminary data<br />
have demonstrated results strongly supporting<br />
our hypothesis that the EGF system correlates<br />
with symptoms in people with treatment-resistant<br />
schizophrenia treated with clozapine.<br />
Sensory integration in schizophrenia<br />
In collaboration with Olivia Carter and students,<br />
the group is examining sensory deficits in<br />
schizophrenia. Previous research has shown that<br />
healthy individuals are both accurate and fast<br />
when it comes to integrating visual information in<br />
different areas of visual space. In contrast, people<br />
with schizophrenia tend to be selectively impaired<br />
on tasks that assess visual integration.<br />
This study has demonstrated that integration of sensory<br />
information is affected across a number of psychotic<br />
disorders and shows some correlation with symptoms.<br />
The group are currently testing whether this deficit<br />
is also present in other sensory modalities. They<br />
have developed an auditory version of the test in<br />
conjunction with Dr Ken McAnally from Defence<br />
Science and Technology Organisation (DSTO).<br />
Such findings will inform us about the changes in<br />
brain function with reference to specific symptoms<br />
across the range of psychotic disorders.<br />
Dr Avril Pereira knew that science was what she wanted to do from a very early age.<br />
Her parents encouraged this interest and when she was still quite young gave her a fairly<br />
serious microscope, which led Avril to dissecting leaves and pricking her thumb to draw blood<br />
for examination. But it was early career work with patients at the Royal Melbourne Hospital that<br />
really fostered her interest in medical research.<br />
Avril has worked at the <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> since 1996. She is now a senior<br />
researcher in the Molecular Psychopharmacology Laboratory, examining how antipsychotic<br />
drugs work in brain cells.<br />
The image Avril holds is that of mouse cortex showing EGF receptors stained brown on the<br />
surface of the neuron (brain cell). 23
24<br />
Molecular Psychopharmacology /<br />
Northern Psychiatry <strong>Research</strong> Centre<br />
continued<br />
Improved <strong>Health</strong> Care delivery<br />
The NPRC, through Russell D’Souza, is undertaking<br />
two major studies examining new treatments for<br />
people with schizophrenia. They are also about<br />
to commence three studies examining new<br />
treatments for people with bipolar disorder and<br />
major depression opening new therapeutic options<br />
for these illnesses. Through grant funding from<br />
beyondblue, Suresh Sundram and the Northern<br />
Clinical <strong>Research</strong> Centre demonstrated that<br />
acculturation is a significant mediator of major<br />
depression and anxiety in people with chronic<br />
physical disorders.<br />
Staff achievements<br />
Suresh Sundram was appointed as an external<br />
consultant to the Australian Human Rights<br />
Commission on mental health issues. In<br />
conjunction with Alison Harrington and Gary<br />
Ennis, Suresh also received a Gold Medal in the<br />
2010 Victorian Public <strong>Health</strong>Care Awards for their<br />
novel method of patient observation in acute<br />
adult psychiatric inpatient units, which resulted in<br />
improved patient and staff safety.<br />
Vaidy Swaminathan received a three year postgraduate<br />
scholarship from the Schizophrenia<br />
<strong>Research</strong> <strong>Institute</strong>.<br />
Avril Pereira was awarded an Early Career<br />
Investigator Award by the Australasian<br />
Schizophrenia Conference.<br />
Conferences & presentations<br />
IndoGlobal Psychiatry Initiative <strong>Annual</strong> Meeting,<br />
Jaipur, India (January 2010)<br />
Schizophrenia International <strong>Research</strong> Conference,<br />
Florence, Italy (April 2010)<br />
International <strong>Mental</strong> <strong>Health</strong> Conference:<br />
Schizophrenia: Where do we go from here?,<br />
Invercargill, New Zealand (May 2010)<br />
Collegium Internationale Neuro-<br />
Psychopharmacologicum Meeting,<br />
Hong Kong (July 2010)<br />
Australasian Schizophrenia Conference,<br />
Sydney, Australia (September 2010)<br />
Biological Psychiatry Australia Meeting,<br />
Melbourne, Australia (September 2010)<br />
International Conference on Schizophrenia,<br />
Chennai, India (October 2010)<br />
Society for Bipolar Disorder India,<br />
Mumbai, India (October 2010)<br />
The Melbourne Brain Symposium,<br />
Melbourne, Australia (November 2010)
Neuropathology Laboratory<br />
Head: Professor Colin Masters<br />
This group is building a better understanding of the molecular mechanisms that contribute to<br />
Alzheimer’s disease.<br />
Specifically, the work aims to isolate the proteins responsible for the neuro-toxicity observed in<br />
Alzheimer’s disease. Isolation of the protein species responsible for Alzheimer’s disease would provide<br />
a great insight into how the disease is caused and its processes.<br />
New information would be used to guide the development of new drugs to prevent or stop the<br />
progression of the disease.<br />
Highlights<br />
Disease marker identification<br />
Over the past year we have improved our techniques to look at peptides in the blood through an<br />
international collaboration with Professor Edward Dratz from Montana State University. Preliminary results,<br />
obtained by Scott Lafoon, indicate that there are several differences in proteins present in diseased<br />
individuals as compared to healthy people. We are continuing the collaboration and aim to identify<br />
proteins that may provide an early diagnosis of Alzheimer’s disease.<br />
Isolation of toxic proteins<br />
In our quest to identify the protein responsible for cell death in Alzheimer’s disease, we have further<br />
developed the methods by which we isolate proteins. By using a wide variety of techniques we are able to<br />
isolate several different forms of the most likely protein, the amyloid beta (Aß) peptide. We are now in the<br />
process of developing further techniques to stabilise this protein for further characterisation. To achieve<br />
high quality identification of the proteins using an advanced Mass Spectrometer we have developed a<br />
collaborative arrangement with Dr Tara Pukala from Adelaide University.<br />
In addition, we have moved from small scale methods to a much larger preparative protocol, which<br />
should provide quite a large amount of protein for future identification and biophysical studies.<br />
Identification of detergent agents to inhibit amyloid formation<br />
An important step toward the overall objective to identify toxic proteins involved in Alzheimer’s disease is<br />
the use of detergents to release proteins from the tissue. In addition to releasing protein, these detergents<br />
are also useful for keeping the isolated protein stable so that further studies may be conducted.<br />
Thus we decided to identify detergents able to reduce the aggregation of the Aß peptide. We screened<br />
96 detergents and identified 30 compounds that inhibit the aggregation process. These detergents will<br />
now be used to further improve our isolation protocols.<br />
25
26<br />
Oxidation Biology Laboratory<br />
Head: Professor Ashley Bush<br />
The Oxidation Biology Laboratory conducts research into Alzheimer's disease and other<br />
neurodegenerative illnesses including Parkinson's disease, Motor neurone disease, Huntington's disease,<br />
dementia with Lewy Bodies and Niemann Pick Disease Type C.<br />
Directed by NHMRC Australia Fellow Professor Ashley Bush, the laboratory examines three major themes in<br />
order to develop new therapeutic approaches based on insights gained:<br />
• Oxidative stress in neurological disorders;<br />
• The molecular and cellular basis of neurotoxicity associated with the deposition of aggregating proteins<br />
in neurodegenerative disorders;<br />
• Understanding the interactions between cellular proteins and biologically important metals.<br />
<strong>Research</strong>ers believe that the hallmark proteins associated with Alzheimer's disease - the Amyloid Precursor<br />
Protein (APP) and its cleavage product amyloid beta (Aß) - are components of the system that regulates<br />
the import and export of the vital trace metals - copper, zinc and iron - within the brain. Even a subtle<br />
imbalance in the normally tight regulation of metals can permit these proteins to interact abnormally and<br />
generate destructive free radicals by redox chemistry.<br />
Highlights<br />
James Duce identified a novel role for APP as a ferroxidase, involved in regulating iron levels within cells.<br />
These ground-breaking results, which showed that the iron-regulating (or ‘ferroxidase’) activity is 75%<br />
decreased in Alzheimer’s disease brain tissue, were published in the high impact ‘Cell’ journal and help<br />
to explain the elevation of iron in neurons in Alzheimer’s disease.<br />
This paper has since opened up a large field of enquiry that ramifies to other organs and diseases,<br />
with separate new projects developing on systemic and brain iron homeostasis. As a testament to<br />
the importance of these findings, James has been invited to present lectures at several international<br />
conferences and universities throughout the year, and also wrote an intensive review entitled ‘Biological<br />
Metals and Alzheimer’s disease: Implications for Therapeutics and Diagnostics’ which was recently<br />
published in the Progress in Neurobiology journal.<br />
James has also been actively involved in an additional line of research, in close collaboration with Blaine<br />
Roberts and other external research groups. Together they are determining the importance of copperbinding<br />
in superoxide dismutase 1 (SOD1). This work is of relevance to amyotrophic lateral sclerosis, a form<br />
of Motor neurone disease, which affects nerve cells in the brain and spinal cord that control voluntary<br />
muscle movement.<br />
Linh Lam holds an image showing a light micrograph of a section through the cerebellum of the brain.
Ya Hui Hung continued to investigate the interaction of copper and cholesterol and how these interactions<br />
may impact on the neurodegenerative process. This work was discussed in her major review article on<br />
the role of copper in the brain and Alzheimer’s disease published in the Journal of Biological Inorganic<br />
Chemistry. A figure illustrating the copper transport pathway in brain cells prepared by Ya Hui also<br />
featured on the journal cover.<br />
In 2010, Ya Hui established a novel line of research for our laboratory into Niemann Pick Disease Type C<br />
(NPC or ‘Childhood Alzheimer’s’). This fatal neurodegenerative disorder shares a number of pathological<br />
features with Alzheimer’s disease. The project will investigate the role of metals in the pathogenesis of NPC<br />
and related diseases. Preliminary findings showed that, in parallel to Alzheimer’s disease, there are indeed<br />
changes in metal content in the brain tissue from a mouse model of NPC. This work helped to forge a new<br />
collaboration with Dan Ory from Washington University School of Medicine.<br />
C. elegans Ageing and Neurodegeneration Unit<br />
Gawain McColl operates our invertebrate laboratory in which he is developing transgenic models<br />
for Alzheimer's and Parkinson's diseases. He established a roundworm ‘C. elegans’ model of<br />
neurodegeneration in which he plans to examine the role of metals in ageing, as well as to discover<br />
and evaluate new drugs to treat these neurodegenerative conditions. An article related to this work was<br />
published in Cell Metabolism and describes how lowered insulin-like signalling results in metabolic and<br />
physiological changes that impact on lifespan.<br />
27
28<br />
Oxidation Biology Laboratory<br />
continued<br />
Translational Medicine Unit<br />
In partnership with Melbourne pharmaceutical<br />
company Prana Biotechnology Ltd, Robert Cherny<br />
and David Finkelstein have overseen a team<br />
responsible for biological evaluation of a novel<br />
drug for the treatment of Parkinson's disease.<br />
Preclinical performance of the drug, PBT434, was<br />
presented at the 2nd World Parkinson's Congress in<br />
Glasgow in September 2010.<br />
Achievements<br />
Ashley Bush received the Royal Australian<br />
and New Zealand College of Psychiatrists<br />
Schering-Plough Senior <strong>Research</strong> Award and<br />
was successful in obtaining both a Senior<br />
Principal <strong>Research</strong> Fellowship and an Australia<br />
Fellowship from the National <strong>Health</strong> and Medical<br />
<strong>Research</strong> Council. The highly prestigious Australia<br />
Fellowship was awarded for his proposal entitled<br />
‘Translational Therapeutics and Diagnostics for<br />
Alzheimer’s Disease’.<br />
The group also received a NHMRC Project Grant,<br />
ARC Linkage Grant and NHMRC Program Grant.<br />
Conferences & presentations<br />
4th <strong>Annual</strong> Alzheimer's and Parkinson's Disease<br />
Symposium, Sydney, Australia (April 2010)<br />
RANZCP 2010 Congress, Auckland, New Zealand<br />
(May 2010)<br />
American Aging Association’s 39th <strong>Annual</strong> Meeting,<br />
Portland, Oregon, USA (June 2010)<br />
The Alzheimer's Association International<br />
Conference on Alzheimer's Disease, Honolulu, USA<br />
(July 2010)<br />
2nd World Parkinson Congress, Glasgow, UK<br />
(September-October 2010)<br />
CSIRO Preventative <strong>Health</strong> Flagship Scientific<br />
Retreat, Adelaide, Australia (October 2010)<br />
The 60th Fujihara Seminar ‘Zinc Signal and Cellular<br />
Functions’, Osaka, Japan (October 2010)<br />
2nd Metallomics <strong>Research</strong> Forum, Kyoto, Japan<br />
(November 2010)<br />
Boden <strong>Research</strong> Conference 2010 ‘Metals<br />
in Biological Systems’, Canberra, Australia<br />
(November-December 2010)
Synaptic Neurobiology Laboratory<br />
Heads: Dr Paul Adlard and Associate Professor David Finkelstein<br />
This laboratory focuses on understanding the role of metals in both normal and pathological aging,<br />
with a specific focus on understanding the basic cellular requirements for normal learning and memory.<br />
These studies will help provide direction for future drug therapy into conditions such as Alzheimer’s<br />
disease and normal age-related cognitive decline.<br />
Work in this Unit is funded by the Joan and Peter Clemenger Trust.<br />
Highlights<br />
Paul Adlard showed that the loss of presynaptic zinc release into the cortical glutamatergic synapse<br />
causes cognitive impairment. The animal model involved (ZnT3 knockouts) could be regarded as a<br />
phenocopy for Alzheimer’s disease, where synaptic zinc is trapped by amyloid and does not reach critical<br />
post-synaptic targets. He also found that ZnT3 levels decline with ageing, and that cognitive loss in aged<br />
mice (and in ZnT3 knockout mice) is rescued by treatment with zinc ionophores clioquinol and PBT2.<br />
These drugs, in development for Alzheimer’s disease, may therefore have potential as treatment not only<br />
for Alzheimer’s disease, but also for age-related cognitive decline – a much more common complaint<br />
(Adlard et al, Journal of Neuroscience, 2010).<br />
The group presented a winning bid to host the next International Society for Zinc Biology meeting, to be<br />
held in Melbourne, Australia in January 2012. This conference will bring scientists together from around the<br />
globe to share their latest results in the field of zinc biology.<br />
During 2010, we also initiated collaboration with researchers to provide us with a mouse model of<br />
schizophrenia (M1 knockout). This model will allow us to explore the underlying mechanisms of the<br />
impaired working memory that characterises schizophrenia.<br />
Conferences & presentations<br />
Zinc Signalling and Cellular Functions meeting, Osaka, Japan (October 2010)<br />
Australian Neuroscience Society, Auckland, New Zealand (January 2010)<br />
29
30<br />
Clinical <strong>Research</strong> Group<br />
Head: Dr Kathryn Ellis<br />
The Clinical <strong>Research</strong> Group aims to detect and understand biological, clinical and cognitive<br />
differences between healthy ageing and dementia, including Alzheimer’s disease. The group<br />
collects, stores and analyses data from human participants and human tissue samples.<br />
The multi-disciplinary team includes neuropsychologists, research nurses, molecular biologists,<br />
neuroimagers and bioinfomaticians. The group is currently involved in:<br />
• Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing;<br />
• the Dominantly Inherited Alzheimer’s Network (DIAN) study;<br />
• the Rates of Change in Cognition (ROCS) study;<br />
• the AIBL Active Clinical Trial;<br />
• the Older Australian Twin Study (OATS);<br />
• Dementia Collaborative <strong>Research</strong> Centre - Early Risk Diagnosis and Prevention.<br />
Highlights<br />
The AIBL Study<br />
The group has assessed and analysed data from over half of the 1112 person cohort. Scientists are currently<br />
analysing data looking for early diagnostic markers. The first phase of this study has been successfully<br />
completed and resulted in the partner Universities and organisations committing to a second phase of the<br />
AIBL study, which will run until 2013. Early results suggest some promising areas to explore further.<br />
Alan Rembach received funding from The Mason Foundation for a project that aims to develop a<br />
non-invasive blood-based test that can be used to determine an individual’s risk and/or provide early<br />
diagnosis of Alzheimer’s disease. Alan is working with Blaine Roberts, using high throughput, multiple<br />
analyte detection platforms, to detect plasma metals to help identify those at risk of developing the<br />
disease. The Mason Foundation has funded the project as part of its efforts to achieve enduring positive<br />
impact in the areas of Chronic Fatigue Syndrome and Alzheimer’s disease through medical research.<br />
Work on finding a potential biomarker commenced using High Performance Liquid Chromatography<br />
(HPLC) to fractionate AIBL baseline plasma samples. Proteins were further separated using 2D sodium<br />
dodecyl sulphate Polyacrylamide gel electrophoresis (SDS-PAGE). Work is continuing to identify proteins<br />
that vary in controls versus Alzheimer’s participants.<br />
Fifteen years ago, Bill Moseley heard Professor Colin Masters talking about his research on the radio. He was calling for healthy ageing volunteers to take part.<br />
Bill had recently retired and, encouraged by his wife, decided he could spare the time to help out.<br />
Bill didn’t have any friends or family with dementia. He just thought it was a worthwhile cause, and one that he was in a position to help. Since then Bill has<br />
completed numerous memory tests, MRI scans and blood tests and even a lumbar puncture as a volunteer for a range of studies including the current Australian<br />
Imaging Biomarkers and Lifestyle (AIBL) study of ageing.<br />
The image Bill holds shows how the plaques in Alzheimer’s disease are seen in post-mortem brain tissue when viewed under a miscroscope.
32<br />
Clinical <strong>Research</strong> Group<br />
continued<br />
NHMRC success and a physical exercise trial<br />
The group began a new NHMRC funded trial in collaboration with the National Ageing <strong>Research</strong><br />
<strong>Institute</strong>. The AIBL Active study is led by Professor Nicola Lautenschlager and will build on previous work<br />
to investigate the effectiveness of physical activity in delaying the progression of cognitive decline and<br />
cardiovascular disease (as measured by brain imaging). This is one of four new studies associated with<br />
AIBL that were successful in receiving NHMRC grants for 2011.<br />
Rate of Change Study<br />
The AIBL Rate of Change Study (AIBL- ROCS) is nearing completion. Nearly 200 volunteers from the AIBL<br />
group have been assessed at short intervals (1-3 months apart) with a brief cognitive assessment.<br />
The study aims to improve methods and trial design for future clinical studies of Alzheimer’s disease so that<br />
subjects are required for shorter time frames in order to decide whether or not treatments are effective.<br />
Data from this study has been presented at last year’s International Conference on Alzheimer’s Disease<br />
(ICAD) and the study has been well received by participants.<br />
Dominantly Inherited Alzheimer’s Network<br />
The DIAN study led by Washington University School of Medicine in St. Louis is a six-year, $16 million<br />
international research collaboration dedicated to understanding dominantly inherited forms of<br />
Alzheimer’s disease. This rare form of the disease is caused by an inherited genetic mutation and usually<br />
strikes earlier in life.<br />
Investigators hope to enrol volunteers from various USA sites, one site in the UK, and an Australian consortium.<br />
MHRI’s Clinical <strong>Research</strong> Group is leading Melbourne’s contribution to this important study.<br />
Internal growth<br />
Due to growth in research activity, four Neuropsychology research assistants have joined the group to<br />
assist with ongoing assessment of AIBL participants. The team has also grown to include four post-doctoral<br />
research students.<br />
A new Liquid Nitrogen tank has been custom made and delivered to cater for ongoing participant sample<br />
storage and to house future replenishments of the AIBL cohort and other CRG’s study samples.
Dementia Collaborative <strong>Research</strong> Centres<br />
The group is playing a key role in phase two of the Dementia Collaborative <strong>Research</strong> Centres (DCRC),<br />
being a partner of DCRC - Early Risk Diagnosis and Prevention. We have a number of projects focusing on<br />
blood biomarkers for Alzheimer’s disease, in addition to a study of a brain imaging compound which may<br />
have clinical utility in the coming years. This exciting work is being conducted in collaboration with the<br />
Australian National University, Austin <strong>Health</strong> and Edith Cowan University among other DCRC partners.<br />
Knowledge transfer<br />
The CRG disseminates its research to both the scientific community and the general public. <strong>Research</strong> from<br />
our group has been presented at a number of scientific conferences, as listed below.<br />
In conjunction with Alzheimer’s Australia, Victoria, we hold a yearly function for participants in the<br />
AIBL study. This includes presentations from leading scientists and provides a forum for questions and<br />
discussion. Participants are also kept up to date via regular mail-outs.<br />
Conferences & presentations<br />
Alzheimer’s Association International Conference on Alzheimer’s Disease (ICAD) and Related Disorders,<br />
Hawaii, USA (July 2010)<br />
International Psychogeriatric Association (IPA) Regional Meeting,<br />
Santiago de Compostela, Spain (September 2010)<br />
14th Congress, Pacific Rim College of Psychiatrists,<br />
Brisbane, Australia (October 2010)<br />
43rd National Conference of the Australian Association of Gerontology,<br />
Hobart, Australia (November 2010)<br />
Science of AIBL Day,<br />
Melbourne, Australia (December 2010)<br />
33
34<br />
Clinical Discovery Unit<br />
Head: Professor Michael Berk<br />
The Clinical Discovery Unit aims to further understand the underlying pathology of mental illness and to<br />
assist in the discovery of better treatments for people with these illnesses.<br />
This collaboration between Barwon <strong>Health</strong> and the <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> is investigating<br />
oxidative and inflammatory stress and psychiatric illnesses. At present, the group is conducting clinical<br />
trials investigating antioxidant treatments for psychiatric illnesses and working together on laboratorybased<br />
projects aimed at clarifying the underlying mechanisms.<br />
As part of the successful Cooperative <strong>Research</strong> Centre (CRC) bid, a number of trials developing novel<br />
therapies based on these pathways are pending.<br />
The Unit is involved in a range of trials to test the benefits of the antioxidant N-acetyl cysteine (NAC) on the<br />
symptoms of disorders including bipolar disorder, depression and autism. In conjunction with these trials,<br />
magnetic resonance spectroscopy is being used to investigate changes in biomarkers following NAC treatment.<br />
Highlights<br />
NAC in bipolar disorder<br />
In this trial all participants were given NAC for two months, after which participants were randomised to<br />
either continue NAC treatment or receive a placebo. Participants continued on the trial for a further six<br />
months and regular interviews were conducted to assess changes in participants’ symptoms. This study<br />
has been completed with the open label phase showing promising results. Results of the maintenance<br />
(randomised) phase will be available in the coming year.<br />
NAC in major depression<br />
This clinical trial is using a double blind, randomised design. As with the bipolar disorder trial, participants<br />
are maintained on their usual treatment and in addition were given either NAC or placebo. Participants<br />
take trial medication for three months. Four weeks following the end of the trial, a follow-up visit is<br />
conducted to establish how participants’ symptoms have changed following the discontinuation of NAC.<br />
The recruitment for this study exceeded the target of 180 participants with 269 people currently taking part.<br />
Recruitment will cease in late January 2011 and results will be analysed midyear.<br />
NAC in autism<br />
There is a lack of evidence clearly exploring the underlying pathophysiology of autism. This disorder not<br />
only has a debilitating effect on the child diagnosed, but also a large impact on the families of people<br />
who care for these children.
Current treatments are often suboptimal and<br />
many have little supporting scientific evidence.<br />
There is however, evidence to suggest alterations<br />
in oxidative and inflammatory pathways in autism<br />
that may contribute to the disorder.<br />
The new study aims to investigate NAC (compared<br />
to placebo) in a small group of children with newly<br />
diagnosed autism. The trial will include a six month<br />
treatment phase followed by two discontinuation<br />
visits to assess the child’s progress both while on<br />
NAC and after completion of the trial. This project is<br />
being undertaken by PhD student, Kristi Villagonzalo.<br />
Future directions<br />
In addition to our new trial in autism, Michael Berk<br />
and his team are planning to explore alternative<br />
treatments to depression and early intervention<br />
in mood disorders. A series of projects examining<br />
the biological foundations of both psychiatric<br />
illness and the effect of NAC are planned. These<br />
include MRS studies, analysis of peripheral markers,<br />
and investigation of the relationship of biological<br />
markers to changes in symptomatology. Studies<br />
of mitochondrially acting agents for bipolar<br />
disorder, and of statins and aspirin in depression<br />
are planned as part of the Cooperative <strong>Research</strong><br />
Centre (CRC).<br />
Staff Achievements<br />
In 2010, the Unit has received a National <strong>Health</strong><br />
and Medical <strong>Research</strong> Council (NHMRC) Project<br />
Grant, two separate Australian Rotary <strong>Health</strong><br />
<strong>Research</strong> Fund grants, a successful application for<br />
a NHMRC Post Doctoral Training Fellowship, grants<br />
from commercial partners and continued support<br />
from the Stanley Medical <strong>Research</strong> <strong>Institute</strong>.<br />
Conferences & presentations<br />
ISBD Biennial Conference 2010,<br />
Sao Paulo, Brazil (March 2010)<br />
IMH 2010 Masterclass,<br />
Vancouver, Canada (April 2010)<br />
International Society for Affective Disorders 5th<br />
Biennial Conference,<br />
Vancouver, Canada (April 2010)<br />
163rd <strong>Annual</strong> Meeting American<br />
Psychiatric Association,<br />
New Orleans, Louisiana, USA (May 2010)<br />
Collegium Internationale Neuro-<br />
Psychopharmacologicum,<br />
Hong Kong, China (June 2010)<br />
<strong>Annual</strong> Norwegian Early Intervention Conference,<br />
Bergen, Norway (September 2010)<br />
Swedish Psychiatric Association,<br />
Gothenburg & Malmoe, Sweden (October 2010)<br />
Danish Society of Affective Disorders,<br />
Copenhagen, Denmark (October 2010)<br />
Society for Neuroscience Meeting,<br />
San Diego, California, USA (November 2010)<br />
Australasian Society for Psychiatric <strong>Research</strong>,<br />
Sydney, Australia (December 2010)<br />
35
36<br />
Victorian Brain Bank Network<br />
Head: Professor Catriona McLean<br />
The Victorian Brain Bank Network (VBBN) collects, processes and stores post-mortem human brains<br />
and related samples from individuals who have had neurological diseases (i.e. Alzheimer’s disease,<br />
Motor neurone disease and Parkinson’s disease) or psychiatric disorders (i.e. bipolar mood disorder,<br />
depression and schizophrenia), as well as normal ‘control’ cases.<br />
The VBBN facilitates the study of brain diseases by providing tissue to researchers who use current<br />
technologies to unlock our understanding of how brain diseases occur. It is hoped that this will<br />
lead to improvements in diagnosis including early diagnostic tests, therapeutic interventions and<br />
preventative strategies.<br />
The VBBN also provides a vital neuropathological diagnostic service and supports continued education of<br />
medical and allied health professionals.<br />
Highlights<br />
Brain and/or spinal cord donations<br />
The VBBN has a total of 895 cases available for research, with 45 new donations received in 2010. New<br />
donations included cases diagnosed with Alzheimer’s disease, Frontotemporal dementias, Huntington’s<br />
disease, Lewy body disease, Motor neurone disease, Multiple sclerosis, Parkinson’s disease, schizophrenia<br />
and control ‘normal’ cases. The VBBN collection makes up 42% of the cases that are available for<br />
research within Australia.<br />
Tissues provided to researchers<br />
The VBBN provided tissue to 56 Australian and international research projects in 2010. The main research<br />
focus of these new and existing projects included Alzheimer’s disease and other dementias, Motor<br />
neurone disease, schizophrenia and bipolar disorder. The Rebecca L Cooper <strong>Research</strong> Laboratory and<br />
the Oxidation Biology Laboratory located at MHRI were among the tissue recipients.<br />
This equates to 5,849 diseased and ‘control’ samples being provided to researchers.<br />
<strong>Research</strong> outcomes utilising tissue from the VBBN resulted in 49 Australian and International publications<br />
and presentations in 2010.
Conferences & presentations<br />
International Society for Biological and Environmental Repositories (ISBER), ‘Diversity in Biobanking:<br />
Embracing differences, harnessing commonalities’, Rotterdam, The Netherlands (May 2010)<br />
Acknowledgment<br />
The VBBN would like to acknowledge the generosity shown by the donor and donor families in donating<br />
tissue to the VBBN. It is an act of great foresight and kindness to give at a time of loss, so that others may<br />
be helped in the future. The clinicians and researchers who benefit from these donations are very grateful<br />
to the donors and their families who support them in these decisions.<br />
37
38<br />
Psychotropic Drug Advisory Service<br />
Head: Professor Nicholas Keks<br />
The Psychotropic Drug Advisory Service provides the latest information on medicines used in psychiatry,<br />
as well as other drugs that can affect behaviour, thought and perception. Unbiased information is<br />
provided to psychiatrists, other medical practitioners, health care providers, consumers, carers and<br />
support agencies.<br />
The service responds to approximately 2000 enquiries each year. Most are received by telephone,<br />
however email enquiries are increasing. Requests for in-service training seminars and presentations to<br />
consumer and carer groups are welcome.<br />
The Department of <strong>Health</strong> funds the service and clinical support is provided by Professor Nicholas Keks at<br />
Monash University.<br />
Highlights<br />
Medications play an integral role in health management for people with a mental illness to alleviate the<br />
distressing symptoms that they experience. Managing these illnesses often requires the combination of a<br />
number of therapies that must be adapted and tailored to the unique needs of the individual.<br />
Drug treatments for mental illness are far from ideal and do not provide a cure. For some, the first<br />
medication they trial resolves their symptoms with few adverse effects. Others trial numerous options<br />
before optimal treatment is achieved. Finding an acceptable balance between therapeutic benefits and<br />
side effects is not always easy. Routine monitoring is required to ensure patient safety.<br />
The Psychotropic Drug Advisory Service can advise on current treatment options, comparison of agents,<br />
possible interactions with other medicines or complementary treatments. Information is available on the<br />
use of medicines in special groups such as the elderly, young, those with other physical conditions and<br />
pregnant or breast feeding women.
Presentations<br />
Each year Christine Culhane provides current information to a variety of professional and<br />
community groups.<br />
Christine presented a poster at the Collegium Internationale Neuropsychopharmacologicum Biannual<br />
Congress in Hong Kong in June 2010 and was invited to present at a satellite meeting of the Pharmacy<br />
Australia Congress for the Australian Association of Consultant Pharmacists in Melbourne in November.<br />
Strong links are maintained with a number of community groups and carer support organisations across<br />
Victoria including MIND Australia, and the Association of Relatives and Friends of the Emotionally and<br />
<strong>Mental</strong>ly Ill. A number of presentations to staff and consumer carer groups have been provided.<br />
Professional Development<br />
It is important in an ever changing environment to maintain currency and keep abreast of drugs in<br />
development, newly marketed drugs, adverse events and best practice. Reviewing the latest literature as<br />
well as attending professional development forums ensures that the information provided maintains a<br />
high quality and is current.<br />
Conferences & presentations<br />
CINP: Biannual meeting of the International College of Neuropsychopharmacologicum,<br />
Hong Kong (June 2010)<br />
Society of Hospital Pharmacists of Australia <strong>Annual</strong> Meeting,<br />
Melbourne, Australia (November 2010)<br />
Pharmacy Australia Congress Australian Association of Consultant Pharmacists Forum,<br />
Melbourne, Australia (November 2010)<br />
39
The Dax Centre<br />
Head: Dr Eugen Koh<br />
New beginnings<br />
The Dax Centre promotes mental health and wellbeing by fostering a greater understanding of the<br />
mind, mental illness and trauma through art and creativity. The Dax Centre has emerged out of the<br />
Cunningham Dax Collection, which has operated as a Unit within the <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong><br />
(MHRI) for the past 20 years.<br />
The Centre is preparing for a series of transitions that will take effect in 2011. It will move from being part<br />
of MHRI to being an independent incorporated entity, and from being an art gallery to becoming a<br />
multifaceted organisation: a hub for all who are interested in the art and mind.<br />
As part of the change, the Dax Centre is due to relocate to the new Melbourne Brain Centre facility at<br />
The University of Melbourne in late 2011. The new gallery will feature a semi-permanent exhibition and an<br />
access gallery for three temporary exhibitions each year. Two of these exhibitions will display works from<br />
the Cunningham Dax Collection, while one will feature work from external groups and organisations. This<br />
purpose built space will provide a state-of-the-art gallery, education resource centre, media room and<br />
curatorial and storage space, ensuring the long-term future of the Collection.<br />
The Cunningham Dax Collection, which has been in operation for more than 30 years, will continue<br />
to exist in its own right as a collection of creative works within the Dax Centre. It is anticipated that this<br />
internationally recognised collection will continue to grow from comprising 15,000 works to over 20,000<br />
works over the next five to ten years.<br />
In the past, the centre has focused on the collection and exhibition of art by people with experience of<br />
mental illness or trauma. In recent years, it has evolved to become a multifaceted institution where the<br />
emotional world is explored through art in many different ways. In addition to the usual activities of an art<br />
institution, such as acquisition, preservation and exhibition, the Dax Centre has developed an education<br />
program that is more assertive and diverse than those commonly found in galleries and museums.<br />
Graeme Doyle, ‘Untitled’, 1978, ballpoint pen and coloured pencil on paper, 36 x 27 cm<br />
Image across: Dr Eugen Koh first joined the Cunningham Dax Collection in 1999 as Senior Lecturer in Art in Psychiatry. He became the director when Dr Eric<br />
Cunningham Dax retired in 2002. He is a consultant psychiatrist and psychoanalytic psychotherapist in private practice. He chairs the Art in <strong>Mental</strong> <strong>Health</strong><br />
Working Group at St Vincent’s, which explores ways of using creative arts in a modern mental health service. Eugen is also a painter himself. The artwork Dr<br />
Eugen Koh holds is one of the works from the Cunningham Dax Collection, now a part of the Dax Centre. 41
42<br />
The Dax Centre<br />
continued<br />
Education<br />
The Dax Centre continued its successful collaboration with MHRI in running Mindfields, an innovative<br />
education program that incorporates art, mental health and neuroscience. It provides an invaluable<br />
educational resource to VCE students and teachers in regional and metropolitan schools and is the only<br />
program of its kind in Australia.<br />
The education team also continued work on the Dax Pack, a new educational resource for Year 11 and<br />
12 Psychology students and teachers. It will provide ideas and activities to assist teachers to create a<br />
safe and supportive classroom environment for teaching about mental health. The Dax Pack will address<br />
frequently held myths and misconceptions associated with mental illness through engaging, classroom<br />
based activities and will also provide online interactive activities for VCE students.<br />
Exhibitions<br />
Throughout 2010, the Centre continued to expand its exhibition program, touring exhibitions to more<br />
regional and rural areas, including Orange, Wodonga and Parliament House in Canberra.<br />
Onsite exhibitions explored a range of themes and included a collaboration with the Jewish Holocaust<br />
Centre, resulting in Out of the Dark: the Emotional Legacy of the Holocaust - a selection of artworks made by<br />
survivors, child survivors and children of survivors of the Holocaust. It explored the psychological effects of<br />
the Holocaust within and throughout these generations.<br />
This was followed by Avoiding the Void, an exhibition that reflected on and engaged with existential ideas<br />
and concerns, and Youth, Interrupted, which presented artworks created by young people in their teens<br />
and twenties whose lives were disrupted by mental illness or trauma. The works used in this exhibition<br />
were created in a variety of contexts ranging from psychiatric hospital art programs (1950s–1980s) to<br />
contemporary settings, including private studios, community art programs, VCE and tertiary art programs,<br />
and a Sri Lankan disaster relief camp.<br />
The final exhibition of 2010 was Picturing Mother and Child, which featured artworks from the Cunningham<br />
Dax Collection that depicted the mother-child relationship, exploring them from psychoanalytic and art<br />
historical perspectives.
‘000 Funding<br />
$320<br />
$100<br />
$220<br />
$250<br />
$50<br />
$10 Donations<br />
State government - general operations<br />
State government - projects<br />
Philanthropy - general operations<br />
Philanthropy - projects<br />
Revenue from programs<br />
<strong>Research</strong><br />
The Centre continues to develop the Art and the Emotional World of Children project, designed to<br />
enhance the emotional literacy of primary-aged children through art. Led by the Dax Centre, a group of<br />
primary school teachers and mental health and art therapy consultants are working together to establish<br />
the model for the program, which will include practical activities based around the art curriculum.<br />
It will produce unique innovative educational resources, a legacy that will benefit generations to come.<br />
The program will be trialled in several primary schools in Melbourne in 2011 with the aim of widespread<br />
implementation through teacher training by 2013.<br />
Funding<br />
The Dax Centre receives funding from the Victorian Government and philanthropic trusts for its core<br />
operations. Outreach programs such as touring exhibitions, its rural education program and other<br />
innovative projects are dependent on funding from philanthropic trusts and private donors.<br />
Onsite Exhibitions<br />
Picturing Mother and Child, 17 November 2010 - 9 April 2011<br />
Youth, Interrupted, 15 April - 6 November 2010<br />
Avoiding the Void, 3 February - 10 April 2010<br />
Out of the Dark: the Emotional Legacy of the Holocaust, 21 October 2009 - 23 January 2010<br />
Touring Exhibitions<br />
Beyond the Three Trees, Orange Regional Gallery, 16 April – 30 May 2010<br />
Healing Childhood Trauma, Family Therapy Conference, Melbourne Exhibition Centre, 6 – 8 October 2010<br />
Beyond the Three Trees, Wodonga Arts Space, 13 October – 7 November 2010<br />
Healing Childhood Trauma, Parliament House, Canberra, 8 November – 10 December 2010<br />
43
44<br />
Development and Communications<br />
Head: Mr Ross Johnstone<br />
The Development and Communications Unit is responsible for raising funds for research and awareness<br />
of the <strong>Institute</strong> and its work. Investment in research through philanthropy is essential if the <strong>Institute</strong> is<br />
to continue to pursue new and innovative pilot projects that might not otherwise be funded through<br />
competitive scientific grants. We are very grateful to the individuals, businesses and philanthropic trusts<br />
and foundations that support us.<br />
Program and equipment funding<br />
While competition for philanthropic funding continues to increase, we have been fortunate to receive<br />
project grants from the Joan and Peter Clemenger Trust, The Marian and EH Flack Trust and The Mason<br />
Foundation, as well as generous ongoing support from a number of trusts as listed in the donation pages<br />
of this report.<br />
A number of major gifts from individuals have enabled the purchase of new equipment, often in memory<br />
of loved ones who have passed away after a struggle with psychiatric or neurodegenerative illness.<br />
Events<br />
The <strong>Institute</strong> continued its partnership with the Royal Yacht Club of Victoria to hold the 4th annual <strong>Mental</strong><br />
<strong>Health</strong> Cup in February 2010. Businesses each sponsored one of eighteen yachts that raced across the<br />
bay with their corporate guests. A raffle on the day added to the excitement of the trophy presentations<br />
and helped contribute to the $50,000 raised through this event.<br />
A new team member was recruited to coordinate the growing number of events aimed at raising both<br />
funds and awareness. MHRI hosted a popular Comedy Fundraiser held at the Comic’s Lounge in March<br />
and is responsible for developing a new culinary event to be launched in April 2011, which is expected to<br />
become a highlight of the Melbourne social calendar.
One in Five continue to present popular events to raise funds for research. A new board was formed and<br />
is working to build the profile of the organisation. Participants in the annual Bolt Blowers Retro Surf event<br />
enjoyed great weather for the first time in the 5-year history of the event. The Extremely Long Lunch was<br />
held in August at Albert by the Lake and record numbers joined the Extreme Challenge in October as<br />
they took on the Melbourne Marathon on World <strong>Mental</strong> <strong>Health</strong> Day. One in Five is a highly valued partner<br />
providing vital funding for psychiatric research and we greatly appreciate the enormous amount of time<br />
and effort this volunteer group puts into the activities undertaken. Particular thanks go to Ryan Wavish and<br />
Linda Karafili who organise the Extreme Challenge every year.<br />
MHRI also benefited from a fundraising dinner presented by Disha, who funded the purchase of a new<br />
gel imaging system for the Rebecca L Cooper Laboratory.<br />
Donor relations<br />
Our individual donors play a huge role in the development of the <strong>Institute</strong>, providing ongoing funding for<br />
new projects and for equipment imperative to our work. In 2010, we conducted our inaugural donor survey,<br />
enhancing our understanding of who our donors are and how they would like us to engage with them.<br />
Results are impacting the way we communicate with existing donors and how we appeal for new ones.<br />
In recognition of the transformative impact donors can make by leaving a gift to a charity in their Will,<br />
the <strong>Institute</strong> engaged an experienced Bequest Officer to develop a strategy and engage donors in<br />
discussions about this method of support. As a result a number of donors have confirmed their intention<br />
to leave a bequest to the <strong>Institute</strong> in their Will.<br />
45
46<br />
Development and Communications<br />
continued<br />
Outreach<br />
The <strong>Institute</strong> continued to host school visits as part of the Mindfields education program for VCE<br />
psychology students, presented in partnership with the Cunningham Dax Collection. Our researchers and<br />
guest speakers from the <strong>Mental</strong> Illness Fellowship delivered talks about the brain and mental illness to over<br />
200 VCE students many of whom travelled from rural and outer suburban schools.<br />
The <strong>Institute</strong> launched a new program of casual but informative evenings called Wine & Wisdom.<br />
Donors and others were invited to hear a short lecture on schizophrenia in May and Alzheimer’s disease in<br />
September, before enjoying some conversation over a glass of wine.<br />
Thanks to John and Alison Kearney, the <strong>Institute</strong> was again able to present both a public and a scientific<br />
lecture by an esteemed international guest. The annual John Cade public lecture was presented by<br />
Professor Julie Andersen, the MHRI Kearney Visiting Professor 2010 from the Buck <strong>Institute</strong> for Age <strong>Research</strong><br />
in California, who is an expert on Parkinson’s disease.<br />
Development Council<br />
As always, the <strong>Institute</strong> is grateful for the support of the Development Council, which provides invaluable<br />
advice and assistance to help us achieve our fundraising and public relations goals. The Council is<br />
chaired by the <strong>Institute</strong>’s Deputy Chair, Trevor Clark OAM, and includes fellow Board member, Rob Gerrand,<br />
as well as other volunteer members drawn from the business community. We were pleased to welcome<br />
David Dean to the committee this year.<br />
Branding<br />
Following the <strong>Institute</strong>’s Strategic Review, a major branding project was undertaken. A new logo, created<br />
pro bono by The Egg, was adopted in September 2010 and the team is working to develop the brand<br />
across all our communications.<br />
Dr Eugen Koh holds one of the artworks from ‘Melancholia’, an upcoming exhibition at The Dax Centre.<br />
Joan Rodriquez, ‘The Phantom’, 1991, mixed media on paper, 60.9 x 57.2 cm
48<br />
Publications<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Adlard PA, Parncutt JM, Finkelstein DI, Bush AI: Cognitive Loss<br />
in Zinc Transporter-3 Knock-Out Mice: A phenocopy for the<br />
synaptic and memory deficits of Alzheimer’s disease?<br />
Journal of Neuroscience 2010, 30(5):1631-1636.<br />
Aggarwal S, Dodd S, Berk M. Restless leg syndrome<br />
caused by olanzapine: a case series. Current Drug Safety.<br />
2010:5(2) 139-141.<br />
Barakat A, Scarr EL, Dean B, Evin G: Decreased neuregulin<br />
c-terminal fragments in schizophrenia prefrontal cortex<br />
brodmann’s area. Schizophrenia <strong>Research</strong> 2010, 124(1-3):<br />
200-207.<br />
Baum L, Chan IHS, Cheung SKK, Goggins WB, Mok V, Lam L,<br />
Leung V, Hui E, Ng C, Woo J, Chiu HFK, Zee BCY, Cheng W,<br />
Chan MH, Szeto S, Lui V, Tsoh J, Bush AI, Lam CWK, Kwok T:<br />
Serum zinc is decreased in Alzheimer’s disease and serum<br />
arsenic correlates positively with cognitive ability.<br />
Biometals 2010, 23(1):173-179.<br />
Berk L, Hallam KT, Colom F, Vieta E, Hasty M, Macneil C,<br />
Berk M: Enhancing medication adherence in patients with<br />
bipolar disorder. Human Psychopharmacology: Clinical<br />
and Experimental 2010, 25(1):1-16.<br />
Berk M, Dean O, Hewitt K, Bush A, Kapczinski F, Jeavons S,<br />
Gama C, Malhi G, Copolov D, Cobb H, Fernandes B:<br />
Glutathione and redox biology in Bipolar Disorder; from<br />
pathophysiology to novel treatments. International Journal<br />
of Neuropsychopharmacology 2010, 13(1):11.<br />
Berk M, Dodd S, Dean OM, Kohlmann K, Berk L, Malhi GS:<br />
The validity and internal structure of the Bipolar Depression<br />
Rating Scale: data from a clinical trial of N-acetylcysteine<br />
as adjunctive therapy in bipolar disorder. Acta<br />
Neuropsychiatrica 2010, 22(5):237-242.<br />
Berk M, Hallam K, Malhi GS, Henry L, Hasty M, Macneil C,<br />
Yucel M, Pantelis C, Murphy B, Vieta E, Dodd S, McGorry PD:<br />
Evidence and implications for early intervention in bipolar<br />
disorder. Journal of <strong>Mental</strong> <strong>Health</strong> 2010, 19(2):113-126.<br />
Berk M, Henry LP, Elkins, KS, Harrigan SM, Harris MG, Herrman H,<br />
Jackson HJ, McGorry PD. The impact of smoking on clinical<br />
outcomes after First Episode Psychosis: Longer-term outcome<br />
findings from the EPPIC 800 follow-up study. The Journal of<br />
Dual Diagnosis. 2010; 6: 212-234<br />
Berk M, Munib A, Dean O, Malhi GS, Kohlmann K, Schapkaitz I,<br />
Jeavons S, Katz F, Anderson-Hunt M, Conus P, Hanna B,<br />
Otmar R, Ng F, Copolov DL, Bush AI. Qualitative methods<br />
in early-phase drug trials: Data and methods from a RCT of<br />
trial of N-acetyl cysteine in schizophrenia. Journal of Clinical<br />
Psychiatry. 2010; 34: 382-385.<br />
Berk M, Ng F, Dodd S, Goldberg JF, Malhi GS: Do we need to<br />
flick the switch? The need for a broader conceptualization<br />
of iatrogenic course aggravation in clinical trials of bipolar<br />
disorder. Psychiatry Clinical Neuroscience 2010, 64(4): 367-371.<br />
Boer S, Sanchez D, Reinieren I, van den Boom T, Udawela M,<br />
Scarr E, Ganfornina MD, Dean B: Decreased kainate<br />
receptors in the hippocampus of apolipoprotein D knockout<br />
mice. Progress in Neuro-Psychopharmacology and Biological<br />
Psychiatry 2010, 34(2):271-278.<br />
Boland MP, Hatty CR, Separovic F, Hill AF, Tew DJ,<br />
Barnham KJ, Haigh CL, James M, Masters CL, Collins SJ:<br />
Anionic phospholipid interactions of the prion protein n<br />
terminus are minimally perturbing and not driven solely by the<br />
octapeptide repeat domain. Journal of Biological Chemistry<br />
2010, 285(42):32282-32292.<br />
Boon WC, van den Buuse M, Wegener N, Martin S, Chua HK,<br />
Bush AI, Masters CL, Adlard PA, Li Q-X: Behavioural<br />
phenotype of APPC100.V717F transgenic mice<br />
over-expressing a mutant A beta-bearing fragment is<br />
associated with reduced NMDA receptor density.<br />
Behavioural Brain <strong>Research</strong> 2010, 209(1):27-35.<br />
Botella-Lopez A, Cuchillo-Ibanez I, Cotrufo T, Mok SS, Li Q-X,<br />
Barquero MS, Dierssen M, Soriano E, Saez-Valero J: beta-amyloid<br />
controls altered Reelin expression and processing in<br />
Alzheimer’s disease. Neurobiology of Disease 2010, 37(3):682-691.
Publications<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Bourgeat P, Chetelat G, Villemagne VL, Fripp J, Raniga P,<br />
Pike K, Acosta O, Szoeke C, Ourselin S, Ames D, Ellis KA,<br />
Martins RN, Masters CL, Rowe CC, Salvado O, Grp AR:<br />
beta-Amyloid burden in the temporal neocortex is related to<br />
hippocampal atrophy in elderly subjects without dementia.<br />
Neurology 2010, 74(2):121-127.<br />
Boyd A, Klug G, Schonberger LB, McGlade A, Brandel JP,<br />
Masters CL, Collins SJ: Iatrogenic Creutzfeldt-Jakob disease in<br />
Australia: time to amend infection control measures for<br />
pituitary hormone recipients? Medical Journal of Australia<br />
2010, 193(6):366-369.<br />
Brazier MW, Volitakis I, Kvasnicka M, White AR, Underwood JR,<br />
Green JE, Han S, Hill AF, Masters CL, Collins SJ: Manganese<br />
chelation therapy extends survival in a mouse model of M1000<br />
prion disease. Journal of Neurochemistry 2010, 114(2):440-451.<br />
Bush AI: Calcium is not all. Neuron 2010, 65(2):143-144.<br />
Callaly T, Ackerly CA, Hyland ME, Dodd S, O’Shea M, Berk M:<br />
A qualitative evaluation of a regional Early Psychosis Service<br />
3 years after its commencement. Australian <strong>Health</strong> Review<br />
2010, 34(4):382-385.<br />
Callaly T, Hyland M, Trauer T, Dodd S, Berk M: Readmission to an<br />
acute psychiatric unit within 28 days of discharge: identifying<br />
those at risk. Australian <strong>Health</strong> Review 2010, 34(3):282-285.<br />
Callaly T, von Treuer K, Dodd S, Berk M: <strong>Mental</strong> health services<br />
for young people - the challenge of integrating services.<br />
Acta Neuropsychiatrica 2010, 22(3):158-160.<br />
Caragounis A, Price KA, Soon CPW, Filiz G, Masters CL, Li Q-X,<br />
Crouch PJ, White AR: Zinc induces depletion and<br />
aggregation of endogenous TDP-43. Free Radical Biology<br />
and Medicine 2010, 48(9):1152-1161.<br />
Castle D, Gilbert M, Lauder S, Murray G, Chamberlain J,<br />
White C, Berk M, Berk L: Group-based psychosocial<br />
intervention for bipolar disorder Reply. British Journal<br />
Psychiatry 2010, 197(3):246.<br />
Castle D, Holdsworth C, Chamberlain J, Berk M, Berk L,<br />
Lauder S, Murray G, Schweitzer I, Piterman L, Gilbert M.<br />
A randomised trial of a comprehenisive group-based<br />
psychosocial intervention for bipolar disorder. British Journal<br />
of Psychiatry. 2010; 196: 383-388.<br />
Castle D, White C, Chamberlain J, Berk M, Berk L, Lauder S,<br />
Murray G, Schweitzer I, Piterman L, Gilbert M: Group-based<br />
psychosocial intervention for bipolar disorder:<br />
randomised controlled trial. British Journal of Psychiatry 2010,<br />
196(5):383-388.<br />
Chavez C, Hollaus M, Scarr E, Pavey G, Gogos A,<br />
van den Buuse M: The effect of estrogen on dopamine and<br />
serotonin receptor and transporter levels in the brain:<br />
An autoradiography study. Brain <strong>Research</strong> 2010, 1321:51-59.<br />
Chetelat G, Villemagne VL, Bourgeat P, Pike KE, Jones G,<br />
Ames D, Ellis KA, Szoeke C, Martins RN, O’Keefe GJ,<br />
Salvado O, Masters CL, Rowe CC and the Australian Imaging,<br />
Biomarkers and Lifestyle <strong>Research</strong> Group: Relationship<br />
between atrophy and ß-amyloid deposition in Alzheimer<br />
disease. Annals of Neurology 2010, 67(3):317-324.<br />
Chetelat G, Villemagne VL, Pike KE, Baron JC, Bourgeat P,<br />
Jones G, Faux NG, Ellis KA, Salvado O, Szoeke C, Martins RN,<br />
Ames D, Masters CL, Rowe CC and the Australian Imaging,<br />
Biomarkers and Lifestyle (AIBL) <strong>Research</strong> Group: Larger<br />
temporal volume in elderly with high versus low beta-amyloid<br />
deposition. Brain 2010, 133(11):3349-3358.<br />
Choy KHC, Dean O, Berk M, Bush AI, van den Buuse M:<br />
Effects of N-acetyl-cysteine treatment on glutathione<br />
depletion and a short-term spatial memory deficit in<br />
2-cyclohexene-1-one-treated rats. European Journal of<br />
Pharmacology 2010, 649(1-3):224-228.<br />
Collins SJ, McGlade A, Boyd A, Masters CL, Klug G: 14-3-3<br />
protein detection and sporadic CJD: the status quo serves<br />
well while awaiting progress. Journal of Neurology,<br />
Neurosurgery and Psychiatry 2010, 8(11):1181.<br />
49
50<br />
Publications<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Collins SJ, Schuur M, Boyd A, Lewis V, Klug GM, McGlade A,<br />
van Oosterhout A, Breedveld G, Oostra BA, Masters C,<br />
Van Duijn CM: No evidence for prion protein gene locus<br />
multiplication in Creutzfeldt-Jakob disease. Neuroscience<br />
Letters 2010, 472(1):16-18.<br />
Conus P, Abdel-Baki A, Harrigan S, Lambert M, McGorry PD,<br />
Berk M: Pre-morbid and outcome correlates of first episode<br />
mania with psychosis: Is a distinction between schizoaffective<br />
and bipolar 1 disorder valid in the early phase of<br />
psychotic disorders? Journal of Affective Disorders 2010,<br />
126(1-2):88-95.<br />
Conus P, Cotton S, Schimmelmann BG, Berk M, Daglas R,<br />
McGorry PD, Lambert M: Pretreatment and outcome<br />
correlates of past sexual and physical trauma in 118 bipolar<br />
1 disorder patients with a first episode of psychotic mania.<br />
Bipolar Disorders 2010, 12(3):244-252.<br />
Conus P, Ward J, Lucas N, Cotton S, Yung AR, Berk M,<br />
McGorry PD: Characterisation of the prodrome to a first<br />
episode of psychotic mania: Results of a retrospective study.<br />
Journal of Affective Disorders 2010, 124(3):341-345.<br />
Coulson CE, Williams LJ, Henry MJ, Berk M, Lubman DI,<br />
Brennan SL, Nicholson GC, Kotowicz MA, Korn S, Pasco JA:<br />
Patterns of alcohol use and associated physical and lifestyle<br />
characteristics according to new Australian guidelines.<br />
Australia and New Zealand Journal of Psychiatry 2010,<br />
44(10):946-951.<br />
Crouch PJ, Hung LW, Soon CP, Tew DJ, Perez KA, Adlard PA,<br />
Bush AI, Masters CL, Cherny RA, Li QX, Donnelly PS,<br />
Barnham KJ, White AR: The molecular mechanism of action<br />
for metal-ligand complexes as potential therapeutics for<br />
Alzheimer’s and other neurodegenerative diseases.<br />
Journal of Neurochemistry 2010, 115(1):10.<br />
Dean B, Cowie T, Sundram S, Pantelis C, Gibbons A, Scarr E:<br />
decreased cortical muscarinic receptors define a subgroup<br />
of subjects with schizophrenia. Schizophrenia <strong>Research</strong> 2010,<br />
117(2-3):252.<br />
Dean B, Tawadros N, Scarr E, Gibbons AS: Regionally-specific<br />
changes in levels of tumour necrosis factor in the dorsolateral<br />
prefrontal cortex obtained postmortem from subjects with<br />
major depressive disorder. Journal of Affective Disorders 2010,<br />
120(1-3):245-248.<br />
Dean O, Bush AI, Berk M, Copolov DL, van den Buuse, M:<br />
Interaction of glutathione depletion and psychotropic drug<br />
treatment in prepulse inhibition in rats and mice.<br />
Pharmacology, Biochemistry and Behaviour. 2010, 97(2):293-300.<br />
Dignam P, Parry P, Berk M: Detached from attachment:<br />
neurobiology and phenomenology have a human face.<br />
Acta Neuropsychiatrica 2010, 22(4):202-206.<br />
Dodd S, Brnabic AJM, Berk L, Fitzgerald PB, de Castella AR,<br />
Filia S, Filia K, Kelin K, Smith M, Montgomery W, Kulkarni J,<br />
Berk M: A prospective study of the impact of smoking on<br />
outcomes in bipolar and schizoaffective disorder.<br />
Comparative Psychiatry 2010, 51(5):504-509.<br />
Dodd S, Kulkarni J, Berk L, Ng F, Fitzgerald PB, de Castella AR,<br />
Filia S, Filia K, Montgomery W, Kelin K, Smith M, Brnabic A,<br />
Berk M: A prospective study of the impact of subthreshold<br />
mixed states on the 24-month clinical outcomes of bipolar 1<br />
disorder or schizoaffective disorder. Journal of Affective<br />
Disorders 2010, 124(1-2):22-28.<br />
D’Souza, R, Piskulic D, Sundram S: A brief dyadic group based<br />
psychoeducation program improves relapse rates in recently<br />
remitted bipolar disorder: A pilot randomised controlled trial.<br />
Journal of Affective Disorders 2010, 120(1-3):272-276.<br />
Duce JA, Bush AI: Biological metals and Alzheimer’s disease:<br />
Implications for therapeutics and diagnostics. Progessive<br />
Neurobiology 2010, 92(1):1-18.<br />
Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K,<br />
Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH,<br />
Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE,<br />
Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI:<br />
Iron-export ferroxidase activity of beta-amyloid precursor<br />
protein is inhibited by zinc in Alzheimer’s disease. Cell 2010,<br />
142(6):857-867.
Publications<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Dunai J, Labuschagne I, Castle DJ, Kyrios M, Rossell SL:<br />
Executive function in body dysmorphic disorder.<br />
Psychological Medicine 2010, 40(9):1541-1548<br />
Eichelsdoerfer JL, Evans JA, Slaugenhaupt SA, Cuajungco MP:<br />
Zinc dyshomeostasis is linked with the loss of mucolipidosis<br />
IV-associated TRPML1 Ion Channel. Journal of Biological<br />
Chemistry 2010, 285(45):34304-34308.<br />
Ellis KA, Rowe CC, Villemagne VL, Martins RN, Masters CL,<br />
Salvado O, Szoeke C, Ames D: Addressing population<br />
aging and Alzheimer’s disease through the Australian<br />
Imaging Biomarkers and Lifestyle Study: Collaboration with<br />
the Alzheimer’s Disease Neuroimaging Initiative. Alzheimer’s<br />
and Dementia 2010, 6(3):291-296.<br />
Evin G, Barakat A, Masters CL: BACE: Therapeutic target and<br />
potential biomarker for Alzheimer’s disease. International<br />
Journal of Biochemistry & Cell Biology 2010, 42(12):1923-1926.<br />
Faux NG, Ritchie CW, Gunn A, Rembach A, Tsatsanis A, Bedo<br />
J, Harrison J, Lannfelt L, Blennow K, Zetterberg H, Ingelsson M,<br />
Masters CL, Tanzi RE, Cummings JL, Herd CM, Bush AI:<br />
PBT2 rapidly improves cognition in Alzheimer’s disease:<br />
Additional Phase II Analyses. Journal of Alzheimers Disease<br />
2010, 20(2):509-516.<br />
Fink G, Editor in Chief. Stress of War, Conflict and Disaster.<br />
Elsevier, Amsterdam 2010.<br />
Fodero-Tavoletti MT, Villemagne VL, Paterson BM, White AR,<br />
Li Q-X, Camakaris J, O’Keefe GJ, Cappai R, Barnham KJ,<br />
Donnelly PS: Bis(thiosemicarbazonato) Cu-64 complexes for<br />
Positron Emission Tomography imaging of Alzheimer’s disease.<br />
Journal of Alzheimers Disease 2010, 20(1):49-55.<br />
Francey SM, Nelson B, Thompson A, Parker AG, Kerr M,<br />
Macneil C, Fraser R, Hughes F, Crisp K, Harrigan S, Wood SJ,<br />
Berk M, McGorry PD: Who needs antipsychotic medication in<br />
the earliest stages of psychosis? A reconsideration of benefits,<br />
risks, neurobiology and ethics in the era of early intervention.<br />
Schizophrenia <strong>Research</strong> 2010, 119(1-3):1-10.<br />
Fullerton JM, Tiwari Y, Agahi G, Heath A, Berk M, Mitchell PB,<br />
Schofield PR: Assessing oxidative pathway genes as risk<br />
factors for bipolar disorder. Bipolar Disorders 2010,<br />
12(5):550-556.<br />
Gavrilescu M, Rossell S, Stuart GW, Shea TL, Innes-Brown H,<br />
Henshall K, McKay C, Sergejew AA, Copolov D, Egan GF:<br />
Reduced connectivity of the auditory cortex in patients with<br />
auditory hallucinations: a resting state functional magnetic<br />
resonance imaging study. Psychological Medicine 2010,<br />
40(7):1149-1158.<br />
George AJ, Gordon L, Beissbarth T, Koukoulas I,<br />
Holsinger RMD, Perreau V, Cappai R, Tan SS, Masters CL,<br />
Scott HS, Li Q-X: A serial analysis of gene expression profile<br />
of the Alzheimer’s disease Tg2576 Mouse Model.<br />
Neurotoxicology <strong>Research</strong> 2010, 17(4):360-379.<br />
George S, Mok SS, Nurjono M, Ayton S, Finkelstein DI,<br />
Masters CL, Li Q-X, Culvenor JG: alpha-synuclein transgenic<br />
mice reveal compensatory increases in Parkinson’s<br />
disease-associated proteins DJ-1 and Parkin and have<br />
enhanced alpha-synuclein and PINK1 levels after<br />
Rotenone treatment. Journal of Molecular Neuroscience<br />
2010, 42(2):243-254.<br />
Gibbons AS, Thomas EA, Scarr E, Dean B: Low density<br />
lipoprotein receptor-related protein and Apolipoprotein E<br />
expression is altered in schizophrenia. Frontiers in Psychiatry<br />
2010, Vol1, Article 19 doi:10.3389/Ppsyt.2010.00019.<br />
Gibbs ME, Bowser DN: Astrocytic adrenoceptors and learning:<br />
alpha(1)-Adrenoceptors. Neurochemistry International 2010,<br />
57(4):404-410.<br />
Gogos A, Gavrilescu M, Davison S, Searle K, Adams J,<br />
Rossell SL, Bell R, Davis SR, Egan GF: Greater superior than<br />
inferior parietal lobule activation with increasing rotation<br />
angle during mental rotation: An fMRI study.<br />
Neuropsychologia 2010, 48(2):529-535.<br />
51
52<br />
Publications<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Gogos A, Joshua N, Rossell SL: Use of the Repeatable Battery<br />
for the Assessment of Neuropsychological Status (RBANS) to<br />
investigate group and gender differences in schizophrenia<br />
and bipolar disorder. Australian and New Zealand Journal of<br />
Psychiatry 2010, 44(3):220-229.<br />
Gogos A, Kwek P, Chavez C, van den Buuse M. Estrogen<br />
treatment blocks 8-hydroxy-2-dipropylaminotetralin- and<br />
Apomorphine-induced disruptions of prepulse inhibition:<br />
Involvement of Dopamine D-1 or D-2 or Serotonin 5-HT1A,<br />
5-HT2A, or 5-HT7 Receptors. Journal of Pharmacology and<br />
Experimental Therapeutics 2010, 333(1):218-227.<br />
Gomes FA, Kauer-Sant’Anna M, Magalhaes PV, Jacka FN,<br />
Dodd S, Gama CS, Cunha A, Berk M, Kapczinski F. Obesity is<br />
associated with previous suicide attempts in bipolar disorder.<br />
Acta Neuropsychiatrica. April 2010, 22(2):63-67.<br />
Gray LJ, Dean B, Kronsbein HC, Robinson PJ, Scarr E:<br />
Region and diagnosis-specific changes in synaptic proteins in<br />
schizophrenia and bipolar 1 disorder. Psychiatry <strong>Research</strong><br />
2010, 178(2):374-380.<br />
Grunze H, Vieta E, Goodwin GM, Bowden C, Licht RW,<br />
Möller HJ, Kasper S WFSBP Task Force On Treatment<br />
Guidelines For Bipolar Disorders. The World Federation of<br />
Societies of Biological Psychiatry (WFSBP) Guidelines for the<br />
Biological Treatment of Bipolar Disorders: Update 2010 on the<br />
treatment of acute bipolar depression. World J Biol Psychiatry.<br />
2010,11(2):81-109.<br />
Guipponi M, Li Q-X, Hyde L, Beissbarth T, Smyth GK,<br />
Masters CL, Scott HS: SAGE analysis of genes differentially<br />
expressed in presymptomatic TgSOD1(G93A) Transgenic<br />
Mice identified cellular processes involved in early stage of<br />
ALS pathology. Journal of Molecular Neuroscience 2010,<br />
41(1):172-182.<br />
Gunn AP, Masters CL, Cherny, RA: Pyroglutamate-Aß:<br />
Role in the natural history of Alzheimer’s disease.<br />
International Journal of Biochemistry and Cell Biology 2010,<br />
42(12):1915-1918.<br />
Haeffner F, Barnham KJ, Bush AI, Brinck T: Generation of soluble<br />
oligomeric beta-amyloid species via copper catalyzed<br />
oxidation with implications for Alzheimer’s disease: A DFT study.<br />
Journal of Molecular Modeling 2010, 16(6):1103-1108.<br />
Haigh CL, Marom, SY, Collins SJ: Copper, endoproteolytic<br />
processing of the prion protein and cell signalling. Frontiers in<br />
Bioscience 2010, 15:1086-1104.<br />
Hare DJ, George JL, Grimm R, Wilkins S, Adlard PA, Cherny RA,<br />
Bush AI, Finkelstein DI, Doble P: Three-dimensional elemental<br />
bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine<br />
lesioned mouse brain. Metallomics 2010, 2(11):745-753.<br />
Harrison CF, Lawson VA, Coleman BM, Kim YS, Masters CL,<br />
Cappai R, Barnham KJ, Hill AF: Conservation of a<br />
glycine-rich region in the prion protein is required for uptake<br />
of prion infectivity. Journal of Biological Chemistry 2010,<br />
285(26):20213-20223.<br />
Horne MK, Nisbet DR, Forsythe JS, Parish CL: three-dimensional<br />
nanofibrous scaffolds incorporating immobilized BDNF<br />
promote proliferation and differentiation of cortical neural<br />
stem cells. Stem Cells and Development 2010, 19(6):843-852.<br />
Hung YH, Bush AI, Cherny RA: Copper in the brain and<br />
Alzheimer’s disease. Journal of Biological Inorganic Chemistry<br />
2010, 15(1):61-76.<br />
Jacka FN, Kremer PJ, Leslie ER, Berk M, Patton GC,<br />
Toumbourou JW, Williams JW: Associations between diet<br />
quality and depressed mood in adolescents: Results from the<br />
Australian <strong>Health</strong>y Neighbourhoods Study. Australian and<br />
New Zealand Journal of Psychiary 2010, 44(5):435-442.<br />
Jacka FN, Pasco JA, Mykletun A, Williams LJ, Hodge AM,<br />
O’Reilly SL, Nicholson GC, Kotowicz MA, Berk M. Association<br />
of Western and traditional diets with depression and anxiety in<br />
women. Am J Psychiatry. 2010 Mar;167(3):305-311.<br />
Jones NC, Martin S, Megatia I, Hakami T, Salzberg MR,<br />
Pinault D, Morris MJ, O’Brien TJ, van den Buuse M: A genetic<br />
epilepsy rat model displays endophenotypes of psychosis.<br />
Neurobiology of Disease 2010, 39(1):116-125.
Publications<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Kato T, Kapczinski F, Berk M. Mitochondrial dysfunction and<br />
oxidative stress. In: Yatham LN, Maj M, editors. Bipolar disorder:<br />
clinical and neurobiological foundations. Hoboken NJ,<br />
John Wiley and Sons, 2010.<br />
Kelin K, Berk M, Spann M, Sagman D, Raskin J, Walker D,<br />
Perahia D: Duloxetine 60 mg/day for the prevention of<br />
depressive recurrences: post hoc analyses from a recurrence<br />
prevention study. International Journal of Clinical Practice<br />
2010, 64(6):719: 726.<br />
Kishigami H, Nagano S, Bush AI, Sakoda S. Monomerized<br />
Cu,Zn-superoxide dismutase induces oxidative stress through<br />
aberrant Cu binding. Free Radical Biology and Medicine<br />
2010, 48(7):945-952.<br />
Kulkarni J, Gurvich C, Lee SJ, Gilbert H, Gavrilidis E,<br />
de Castella A, Berk M, Dodd S, Fitzgerald PB, Davis SR:<br />
Piloting the effective therapeutic dose of adjunctive selective<br />
estrogen receptor modulator treatment in postmenopausal<br />
women with schizophrenia. Psychoneuroendocrinology 2010,<br />
35(8):1142-1147.<br />
Labuschagne I, Castle DJ, Dunai J, Kyrios M, Rossell SL:<br />
An examination of delusional thinking and cognitive styles in<br />
body dysmorphic disorder. Australian and New Zealand<br />
Journal of Psychiatry 2010, 44(8):706-712.<br />
Lawson VA, Haigh CL, Roberts B, Kenche VB, Klemm HMJ,<br />
Masters CL, Collins SJ, Barnham KJ, Drew SC: Near-infrared<br />
fluorescence imaging of apoptotic neuronal cell death in<br />
a live animal model of Prion disease. ACS Chemical<br />
Neuroscience 2010, 1(11):720-727.<br />
Lawson VA, Lumicisi B, Welton J, Machalek D, Gouramanis K,<br />
Klemm HM, Stewart JD, Masters CL, Hoke DE, Collins SJ, Hill AF:<br />
Glycosaminoglycan sulphation affects the seeded misfolding<br />
of a mutant prion protein. PLoS One 2010, 5(8):9.<br />
Lee JY, Cho E, Kim TY, Kim DK, Palmiter RD, Volitakis I,<br />
Kim JS, Bush AI, Koh JY: Apolipoprotein E ablation decreases<br />
synaptic vesicular zinc in the brain. Biometals 2010,<br />
23(6):1085-1095<br />
Lei P, Ayton S, Finkelstein DI, Adlard PA, Masters CL,<br />
Bush AI: Tau protein: Relevance to Parkinson’s disease.<br />
International Journal of Biochemistry & Cell Biology 2010,<br />
42(11):1775-1778.<br />
Li HY, Kim WS, Guillemin GJ, Hill AF, Evin G, Garner B:<br />
Modulation of amyloid precursor protein processing by<br />
synthetic ceramide analogues. Biochimica et Biophysica<br />
Acta. Molecular and Cell Biology of Lipids 2010,<br />
1801(8):887-895.<br />
Lim S, Paterson BM, Fodero-Tavoletti MT, O’Keefe GJ,<br />
Cappai R, Barnham KJ, Villemagne VL, Donnelly PS: A copper<br />
radiopharmaceutical for diagnostic imaging of Alzheimer’s<br />
disease: a bis(thiosemicarbazonato)copper(II) complex that<br />
binds to amyloid-beta plaques. Chemical Communications<br />
2010, 46(30):5437-5439.<br />
Lubman DI, Berk M: Pharmacotherapy for co-occurring<br />
alcohol and drug disorders in schizophrenia and bipolar<br />
disorder: where is the evidence? Acta Neuropsychiatrica<br />
2010, 22(2):95-97.<br />
Lui JK, Laws SM, Li QX, Villemagne VL, Ames D, Brown B,<br />
Bush AI, De Ruyck K, Dromey J, Ellis KA, Faux NG, Foster J,<br />
Fowler C, Gupta V, Hudson P, Laughton K, Masters CL,<br />
Pertile K, Rembach A, Rimajova M, Rodrigues M, Rowe CC,<br />
Rumble R, Szoeke C, Taddei K, Taddei T, Trounson B, Ward V,<br />
Martins RN: Plasma amyloid-beta as a biomarker in<br />
Alzheimer’s disease: The AIBL Study of Aging. Journal of<br />
Alzheimers Disease 2010, 20(4):1233-1242.<br />
Macneil CA, Hasty MK, Berk M, Henry L, Evans M, Daglas R,<br />
McGorry PD, Conus P: First Episode Bipolar Disorder:<br />
Outcomes from a manualised psychotherapy intervention.<br />
Bipolar Disorders 2010, 12:35-36.<br />
Macneil CA, Hasty MK, Conus P, Berk M: Termination of<br />
therapy: what can clinicians do to maximise gains?<br />
Acta Neuropsychiatrica 2010, 22(1):43-45.<br />
53
54<br />
Publications<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Magalhaes PVS, Berk M, Cereser KM, Kunz M, Gomes FA,<br />
Fernandes BS, Jakobson L, Kapczinski F, Gama CS. Validity of<br />
the Portuguese version of the Bipolar Depression Rating Scale.<br />
Acta Neuropsychiatrica 2010, 22(2):100-101.<br />
McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD,<br />
Bush AI, Kapahi P, Lithgow GJ: Insulin-like signaling determines<br />
survival during stress via posttranscriptional mechanisms in C.<br />
elegans. Cell Metabolism 2010, 12(3):260-272.<br />
McLeod MC, Scarr E, Dean B: Effects of benzodiazepine<br />
treatment on cortical GABA(A) and muscarinic receptors:<br />
Studies in schizophrenia and rats. Psychiatry <strong>Research</strong> 2010,<br />
179(2):139 -146.<br />
Money TT, Scarr E, Udawela M, Gibbons AS, Jeon WJ, Seo MS,<br />
Dean B: Treating schizophrenia: Novel targets for the<br />
cholinergic system. CNS Neurological Disorders - Drug Targets<br />
2010 9(2):241-256.<br />
Mykletun A, Jacka F, Williams L, Pasco J, Henry M,<br />
Nicholson GC, Kotowicz MA, Berk M: Prevalence of mood<br />
and anxiety disorder in self reported irritable bowel syndrome<br />
(IBS). An epidemiological population based study of women.<br />
BMC Gastroenterology 2010, 5(10):88.<br />
Nisbet DR, Rodda AE, Horne MK, Forsythe JS, Finkelstein DI:<br />
Implantation of functionalized thermally gelling xyloglucan<br />
hydrogel within the brain: Associated neurite infiltration<br />
and inflammatory response. Tissue Engineering Part A 2010,<br />
16(9):2833-2842.<br />
Nisbet RM, Harrison CF, Lawson VA, Masters CL, Cappai R,<br />
Hill AF: Residues surrounding the glycosylphosphatidylinositol<br />
anchor attachment site of PrP modulate prion infection:<br />
Insight from the resistance of rabbits to prion disease.<br />
Journal of Virology 2010, 84(13): 6678-6686.<br />
Okamura N, Villemagne VL, Drago J, Pejoska S, Dhamija RK,<br />
Mulligan RS, Ellis JR, Ackermann U, O’Keefe G, Jones G,<br />
Kung HF, Pontecorvo MJ, Skovronsky D, Rowe CC: In Vivo<br />
measurement of vesicular monoamine transporter Type 2<br />
density in Parkinson disease with F-18-AV-133. Journal of<br />
Nuclear Medicine 2010, 51(2):223-228.<br />
Olshina MA, Angley LM, Ramdzan YM, Tang JW, Bailey MF,<br />
Hill AF, Hatters DM: Tracking mutant huntingtin aggregation<br />
kinetics in cells reveals three major populations that include<br />
an invariant oligomer pool. Journal of Biological Chemistry<br />
2010, 285(28):21807-21816.<br />
Pasco JA, Jacka FN, Williams LJ, Henry MJ, Nicholson GC,<br />
Kotowicz MA, Berk M: Clinical implications of the cytokine<br />
hypothesis of depression: The association between use of<br />
statins and aspirin and the risk of major depression.<br />
Psychotherapy and Psychosomatics 2010, 79(5):323-325.<br />
Pasco JA, Nicholson GC, Williams LJ, Jacka FN, Henry MJ,<br />
Kotowicz MA, Schneider HG, Leonard BE, Berk M.<br />
Association of high-sensitivity C-reactive protein with<br />
de novo major depression. British Journal of Psychiatry.<br />
2010; 197: 372-377.<br />
Pereira A, Zhang B, Malcolm P, Fink G, Sundram S:<br />
Antipsychotic drug modulation of downstream targets of<br />
the EGF-ERK cell signaling pathway in prefrontal cortex and<br />
striatum. International Journal of Neuropsychopharmacology<br />
2010, 13(1):104.<br />
Perreau VM, Orchard S, Adlard PA, Bellingham SA, Cappai R,<br />
Ciccotosto GD, Cowie TF, Crouch PJ, Duce JA, Evin G,<br />
Faux NG, Hill AF, Hung YH, James SA, Li Q-X, Mok SS, Tew DJ,<br />
White AR, Bush AI, Hermjakob H, Masters CL: A domain level<br />
interaction network of amyloid precursor protein and A beta<br />
of Alzheimer’s disease. Proteomics 2010, 10(12):2377-2395.<br />
Pettikiriarachchi JTS, Parish CL, Shoichet MS,<br />
Forsythe JS Nisbet DR: Biomaterials for brain tissue engineering.<br />
Australian Journal of Chemistry 2010, 63(8):1143-1154.<br />
Rekas A, Knott RB, Sokolova A, Barnham KJ, Perez KA, Masters<br />
CL, Drew SC, Cappai R, Curtain CC, Pham CLL: The structure<br />
of dopamine induced alpha-synuclein oligomers. European<br />
Biophysics Journal Biophysics Letters 2010, 39(10):1407-1419.<br />
Rowe CC, Ellis KA, Rimajova M, Bourgeat P, Pike KE, Jones G,<br />
Fripp J, Tochon-Danguy H, Morandeau L, O’Keefe G, Price R,<br />
Raniga P, Robins P, Acosta O, Lenzo N, Szoeke C,<br />
Salvado O, Head R, Martins R, Masters CL, Ames D,
Publications<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Villemagne VL: Amyloid imaging results from the Australian<br />
Imaging, Biomarkers and Lifestyle (AIBL) Study of aging.<br />
Neurobiological Aging 2010, 31(8):1275-1283.<br />
Scarr E, Money T, Dean B: Decreased mu opioid receptor<br />
availability in subjects with schizophrenia who died by suicide.<br />
Schizophrenia <strong>Research</strong> 2010, 117(2-3):487.<br />
Singleton WCJ, McInnes KT, Cater MA, Winnall WR, McKirdy R,<br />
Yu Y, Taylor PE, Ke BX, Richardson DR, Mercer JFB,<br />
La Fontaine S: Role of glutaredoxin1 and glutathione in<br />
regulating the activity of the copper-transporting P-type<br />
ATPases, ATP7A and ATP7B. Journal of Biological Chemistry<br />
2010, 285(35):27111-27121.<br />
Smith DG, Ciccotosto GD, Tew DJ, Perez K, Curtain CC,<br />
Boas JF, Masters CL, Cappai R, Barnham KJ: Histidine 14<br />
modulates membrane binding and neurotoxicity of the<br />
Alzheimer’s disease amyloid-beta peptide. Journal of<br />
Alzheimers Disease 2010, 19(4):1387-1400.<br />
Soon CPW, Crouch PJ, Turner BJ, McLean CA, Laughton KM,<br />
Atkin JD, Masters CL, White AR, Li Q-X: Serum matrix<br />
metalloproteinase-9 activity is dysregulated with disease<br />
progression in the mutant SOD1 transgenic mice.<br />
Neuromuscular Disorders 2010, 20(4):260-266.<br />
Tabrett CA, Harrison CF, Schmidt B, Bellingham SA, Hardy T,<br />
Sanejouand YH, Hill AF, Hogg PJ: Changing the solvent<br />
accessibility of the prion protein disulfide bond markedly<br />
influences its trafficking and effect on cell function.<br />
Biochemical Journal 2010, 428:169-182<br />
Torkamani A, Dean B, Schork NJ, Thomas EA: Coexpression<br />
network analysis of neural tissue reveals perturbations in<br />
developmental processes in schizophrenia. Genome<br />
<strong>Research</strong> 2010, 20(4):403-412.<br />
van den Buuse M, Choy C, Klug M, Hill R: Studying the<br />
‘two-hit’ hypothesis of schizophrenia in rats and mice: role of<br />
Brain-Derived Neurotrophic Factor (BDNF). International<br />
Journal of Neuropsychopharmacology 2010, 13(1):68.<br />
van den Buuse M: Modeling the positive symptoms of<br />
schizophrenia in genetically modified mice: pharmacology<br />
and methodology aspects. Schizophrenia Bulletin 2010,<br />
36(2):246-270.<br />
Villagonzalo KA, Dodd S, Dean O, Gray K, Tonge B, Berk M.<br />
Oxidative pathways as a drug target for the treatment of<br />
autism. Expert Opinion in Therapeutic Targets 2010;<br />
14(12); 1301-1310.<br />
Villagonzalo KA, Dodd S, Ng F, Mihaly S, Langbein A,<br />
Berk M: The utility of the Mood Disorders Questionnaire as a<br />
screening tool in a methadone maintenance treatment<br />
program. International Journal of Psychiatry in Clinical<br />
Practice 2010, 14(2):150-153.<br />
Villemagne VL, Perez KA, Pike KE, Kok WM, Rowe CC,<br />
White AR, Bourgeat P, Salvado O, Bedo J, Hutton CA,<br />
Faux NG, Masters CL, Barnham KJ: Blood-borne amyloid-beta<br />
dimer correlates with clinical markers of Alzheimer’s disease.<br />
Journal of Neuroscience 2010, 30(18):6315-6322.<br />
Villemagne VL, Pike K, Pejoska S, Boyd A, Power M, Jones G,<br />
Masters CL, Rowe CC: C-11-PiB PET A(Bri) Imaging in<br />
Worster-Drought Syndrome (Familial British Dementia):<br />
A Case <strong>Report</strong>. Journal of Alzheimers Disease 2010,<br />
19(2):423-428.<br />
Williams L, Jacka F, Pasco J, Henry M, Dodd S, Nicholson G,<br />
Kotowicz M, Berk M: The prevalence of mood and anxiety<br />
disorders in Australian women. Australasian Psychiatry 2010,<br />
18(3):250-255.<br />
Zheng ZQ, White C, Lee J, Peterson TS, Bush AI, Sun GY,<br />
Weisman GA, Petris MJ: Altered microglial copper<br />
homeostasis in a mouse model of Alzheimer’s disease.<br />
Journal of Neurochemistry 2010, 114(6):1630-1638.<br />
55
56<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
DIRECTORS' REPORT<br />
The Directors present this report on The <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> (MHRI) for the year ended 31 December 2010.<br />
Description of the short- and long-term objective<br />
MHRI’s long term vision is to become a global leader in research that improves the lives of people affected by mental illness<br />
including psychotic illness and neurodegenerative disease. Our immediate objective is to conduct sustainable, basic<br />
neuroscience, clinical and public health research of the highest quality.<br />
Details of the entity’s strategy for achieving those short- and long-term objectives<br />
MHRI has adopted a growth strategy in order to meet its long- and short- term objectives and is aiming to increase our revenue<br />
(both grant income and philanthropic donations), increase the number of researchers working at the <strong>Institute</strong> and grow the<br />
number of publications in high quality scientific journals.<br />
Principal Activities<br />
MHRI engages in basic medical research in neuroscience, clinical and public health research. The <strong>Institute</strong> has two major<br />
research streams; Neurodegeneration and Neuropsychiatry.<br />
Details of how those activities assisted in achieving the entity’s short- and long-term objectives<br />
Our activities have resulted in us achieving key growth objectives in 2010 by sustainably growing our overall income base year<br />
on year by 13% and by increasing our peer reviewed grant income year on year by 6%.<br />
Details of how the entity measures its performance, including any key performance indicators used by the entity<br />
The <strong>Institute</strong>’s performance is measured by annual revenue, including revenue from peer-reviewed grants and the number of<br />
publications in high impact scientific journals and cited in other publications.<br />
The Year Ahead<br />
MHRI has established a state-of-the-art research facility in Parkville in collaboration with the University of Melbourne and the<br />
Florey Neuroscience <strong>Institute</strong>s. This building will be completed in mid to late 2011 and our researchers engaged in<br />
wet-laboratory research will co-relocate into this new facility.<br />
In addition, the Cunningham Dax Collection will be relocated to the Parkville facility to become the human face of<br />
neuroscience research. A new incorporated entity, The Dax Centre Ltd, will be established to manage and to expand the<br />
education activities around the collection.<br />
ABN 48 101 228 451
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
Directors<br />
The names and qualifications of each person who has been a Director during the period and to date of this report are:<br />
Dr Sandra Hacker AO, MBBS, DPM, FRANZCP, FAICD - Chair<br />
Mr Trevor Clark OAM, ACIS, FAMI, FAICD, CPM - Deputy Chair<br />
Mr Rob Gerrand, BA, FAMI, FAICD<br />
Laureate Professor Colin Masters, BMedSc (Hons), MBBS, MD, Hon DLitt WAust, FRCPath, FRCPA, FAA, FTSE - Executive Director<br />
Professor James Angus, BSc, PhD, FAA (Leave of absence since November 2010)<br />
Professor Steve Wesselingh, MBBS, FRACP, PhD<br />
Ms Katarina Klaric, BA, LLB, LLM - resigned 27 May 2010<br />
Ms Jennifer Labourne, BBus, FCPA<br />
Professor Ingrid Winship, MBChB, MD, FRACP, FACD<br />
Mr Andrew Stripp, MSc (Clin Psychol), BBSc (Hons)<br />
The Directors have been in office since the start of the period to the date of this report unless otherwise stated.<br />
Ms Lisa Keam, Chief Operating Officer, held the position of company secretary at the end of the financial period.<br />
57
58<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
Directors Meetings<br />
During the financial period, 20 meetings of directors (including committees) were held.<br />
Attendances by each director were as follows;<br />
Committee Meetings<br />
Directors’ Intellectual Development Audit & Risk Cunningham Dax<br />
Meetings Property & Council Management Advisory<br />
Commercialisation Committee<br />
Committee<br />
Eligible Attended Eligible Attended Eligible Attended Eligible Attended Eligible Attended<br />
Dr S Hacker 4 4 4 4 1 1<br />
Mr T Clark 4 4 11 11<br />
Prof C Masters 4 4 0 0 4 4<br />
Mr R Gerrand 4 4 11 8 4 2<br />
Prof J Angus 4 0<br />
Ms K Klaric 2 2 0 0 2 1<br />
Ms J Labourne 4 4 4 4<br />
Prof S Wesselingh 4 2<br />
Prof I Winship 4 2<br />
Mr A Stripp 4 4 4 0<br />
No Board Member received any benefit from the <strong>Institute</strong>, apart from Professor Colin Masters, who received remuneration in<br />
respect of his employment as Executive Director.
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
Member’s guarantee<br />
If the company is wound up, the Constitution states that each member is required to contribute a maximum of $25 each<br />
towards meeting any outstanding obligations of the company. At 31 December 2010, the number of members was 30.<br />
Independence Declaration<br />
The lead auditor’s independence declaration for the period has been received and can be found on page 20<br />
of this report.<br />
Dr Sandra Hacker<br />
Chair<br />
Signed at Melbourne, dated this 11th day of April 2011.<br />
59
60<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
STATEMENT OF CHANGES IN EQUITY FOR THE YEAR ENDED 31 DECEMBER 2010<br />
<strong>Research</strong> Capital Asset Revaluation Unrealised gain Accumulated Total<br />
Funds Reserves Reserve on Investment Deficit/Surplus<br />
Reserve<br />
$ $ $ $ $ $<br />
Balance 1 January 2010 2,799,402 5,713,141 - 66,068 (1,800,113) 6,778,498<br />
Net surplus for period - - - - 11,320,569 11,320,569<br />
Other comprehensive income - - 2,526,383 (12,464) - 2,513,919<br />
Transfer from accumulated<br />
Deficit/Surplus (1,485,204) 11,005,660 - - (9,520,456) -<br />
Transfers to/from reserves 50,882 1,200,000 - - - 1,250,882<br />
Balance at<br />
31 December 2010 1,365,080 17,918,801 2,526,383 53,604 - 21,863,868<br />
<strong>Research</strong> Asset Revaluation Unrealised gain Accumulated Total<br />
Funds Reserves Reserve on Investment Deficit/Surplus<br />
Reserve<br />
$ $ $ $ $ $<br />
Balance 1 July 2009 2,818,475 5,713,141 - 37,874 (1,266,404) 7,303,086<br />
Net deficit for period - - - - (533,709) (533,709)<br />
Other comprehensive income - - - 28,194 - 28,194<br />
Transfers to/from reserves (19,073) - - - - (19,073)<br />
Balance at<br />
31 December 2009 2,799,402 5,713,141 - 66,068 (1,800,113) 6,778,498<br />
The accompanying notes form part of this financial report
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
STATEMENT OF COMPREHENSIVE INCOME FOR THE YEAR ENDED 31 DECEMBER 2010<br />
INCOME<br />
NOTE 12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
Grants 2(A) 7,938,047 3,373,315<br />
Contract research fees 2,161,894 1,251,819<br />
Public support 2(B) 1,897,685 598,569<br />
Interest 249,493 116,923<br />
Dividends 8,950 3,160<br />
Other revenue 397,690 480,158<br />
TOTAL INCOME excluding asset recognition and relocation grant 12,653,759 5,823,944<br />
EXPENDITURE<br />
Salaries and on costs 7,590,898 3,642,464<br />
Scientific equipment purchases 7 (E) 69,790 30,763<br />
Scientific consumables 1,475,667 865,375<br />
Scientific support 1,111,331 715,355<br />
Depreciation 3 (B) 938,655 418,188<br />
Infrastructure expenses 1,152,509 685,508<br />
Provision for doubtful debts - -<br />
TOTAL EXPENDITURE 12,338,850 6,357,653<br />
NET SURPLUS / (DEFICIT) before asset recognition and relocation grant 314,909 (533,709)<br />
Land asset recognised on transfer of Committee of Management 2(C) 8,981,000 -<br />
Relocation grant income - Cunningham Dax Collection 2(D) 2,024,660 -<br />
NET SURPLUS/ (DEFICIT) 13 11,320,569 (533,709)<br />
OTHER COMPREHENSIVE INCOME<br />
Gain on revaluation of property 12 2,526,383 -<br />
Net change in market value of investments recognised directly in equity (12,463) 28,194<br />
TOTAL COMPREHENSIVE SURPLUS (DEFICIT) FOR PERIOD 13,834,489 (505,515)<br />
The accompanying notes form part of this financial report<br />
61
62<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
CASH FLOW STATEMENT FOR THE YEAR ENDED 31 DECEMBER 2010<br />
NOTE 12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
Inflows/(Outflows) Inflows/(Outflows)<br />
CASH FLOWS FROM OPERATING ACTIVITIES<br />
Grants received 7,922,020 3,486,419<br />
Public support received 1,897,685 598,569<br />
Interest received 241,898 242,962<br />
Dividends received 451 3,160<br />
Contract research fees received 2,370,546 1,075,228<br />
Other revenue received 436,780 523,798<br />
Payments to suppliers and employees (12,242,040) (6,389,364)<br />
Payments for scientific equipment (75,004) (21,571)<br />
Net cash provided by operating activities 16(B) 552,336 (480,799)<br />
CASH FLOWS FROM INVESTING ACTIVITIES<br />
Fixed asset purchases (835,560) (93,072)<br />
Net sale/(purchase) of investments (523,397) 349,533<br />
Redemption of Dax relocation funds 3,224,660 -<br />
Payments for Dax building construction (2,216,929) -<br />
Net cash used by investing activities (351,226) 256,461<br />
CASH FLOWS FROM FINANCING ACTIVITIES<br />
Net (decrease)/increase in cash held 201,110 (224,338)<br />
Cash and cash equivalents at the beginning of the financial period 373,166 597,504<br />
Cash and cash equivalents at the end of the financial period 16(A) 574,276 373,166<br />
The accompanying notes form part of this financial report
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
BALANCE SHEET AS AT 31 DECEMBER 2010<br />
ASSETS<br />
CURRENT ASSETS<br />
NOTE 31 December 2010 31 December 2009<br />
Cash and cash equivalents 4 574,276 373,166<br />
Trade and other receivables 5 1,428,127 769,660<br />
Stock on Hand 5(A) 23,287 -<br />
Financial assets 6 5,068,523 4,545,126<br />
TOTAL CURRENT ASSETS 7,094,213 5,687,952<br />
NON-CURRENT ASSETS<br />
Financial assets 6 159,658 163,622<br />
Property, plant and equipment 7 18,488,005 2,726,515<br />
Cunningham Dax relocation account 6,11 - 3,132,430<br />
MHRI accommodation relocation account 6,11 10,688,031 10,047,226<br />
TOTAL NON-CURRENT ASSETS 29,335,694 16,069,793<br />
TOTAL ASSETS 36,429,907 21,757,745<br />
CURRENT LIABILITIES<br />
Trade and other payables 8 2,876,908 647,833<br />
Unexpended project grants 9 150,000 223,876<br />
Provisions for employee benefits 10 777,782 858,806<br />
TOTAL CURRENT LIABILITIES 3,804,690 1,730,515<br />
NON-CURRENT LIABILITIES<br />
Provisions for employee benefits 10 73,318 69,076<br />
Cunningham Dax relocation account 11 - 3,132,430<br />
MHRI accommodation relocation account 11 10,688,031 10,047,226<br />
TOTAL NON-CURRENT LIABILITIES 10,761,349 13,248,732<br />
TOTAL LIABILITIES 14,566,039 14,979,247<br />
NET ASSETS 21,863,868 6,778,498<br />
The accompanying notes form part of this financial report<br />
63
64<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
BALANCE SHEET AS AT 31 DECEMBER 2010 - Continued.<br />
EQUITY<br />
NOTE 31 December 2010 31 December 2009<br />
<strong>Research</strong> funds 12 1,365,080 2,799,402<br />
Capital reserves 12 17,918,801 5,713,141<br />
Asset revaluation reserve 12 2,526,383 -<br />
Unrealised gain on investment reserve 1(G) 53,604 66,068<br />
Accumulated deficit 13 - (1,800,113)<br />
TOTAL EQUITY 21,863,868 6,778,498<br />
The accompanying notes form part of this financial report
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010<br />
NOTE 1: STATEMENT OF ACCOUNTING POLICIES<br />
The financial report is a general purpose financial report that has been prepared in accordance with Accounting<br />
Standards - Reduced Disclosure Requirements and other authoritative pronouncements of the Australian Accounting<br />
Standards Board and the requirements of the Corporations Act 2001.<br />
The financial report covers the <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> as an individual entity.<br />
<strong>Report</strong>ing Basis and Conventions<br />
The financial report has been prepared on an accruals basis and is based on historical cost convention and except<br />
where stated, does not take account of current valuations of non-current assets, except for land and buildings<br />
valued at fair value, and listed shares valued at market value.<br />
The following is a summary of the material accounting policies adopted by the company in the preparation of the<br />
financial report. The accounting policies have been consistently applied unless otherwise stated.<br />
(A) PROPERTY, PLANT AND EQUIPMENT<br />
Property<br />
MHRI occupy a Crown Land site at 155 Oak Street, Parkville. This site was previously leased by MHRI. During 2010,<br />
MHRI was delegated responsibility to manage the site as a Committee of Management. The value of the land had<br />
not been recognised as a controlled asset previously, and is now recognised at fair value based on a valuation<br />
prepared for the Valuer-General in 2009. The buildings at 155 Oak Street, Parkville were previously recognised as<br />
controlled assets, and have been revalued during the 2010 year based on the same valuation.<br />
Plant and Equipment<br />
Plant and equipment are measured on the cost basis. The carrying amount of plant and equipment is reviewed<br />
annually to ensure it is not in excess of the recoverable amount from these assets. Due to the nature of the <strong>Institute</strong>’s<br />
funding, capital equipment acquired for scientific purposes prior to June 2004 was fully written off against grants in<br />
the year of purchase. All assets with a purchase value of less than $2,000 are written off in the year of purchase.<br />
Depreciation<br />
Scientific and non-scientific plant and equipment are shown as fixed assets in the Balance Sheet and depreciated<br />
on a straight line basis over the expected useful life of the asset from the time the asset is held ready for use.<br />
Building & Improvements 5% - 20%<br />
Equipment, Furniture & Fittings 10% to 33.33%<br />
Scientific Equipment 10% to 33.33%<br />
65
66<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
(B) EMPLOYEE BENEFITS<br />
Provision is made for the <strong>Institute</strong>’s liability for employee entitlements arising from services rendered by employees<br />
to balance date. Employee entitlements expected to be settled within one year have been measured at their<br />
nominal amount and recorded as Current Liabilities. Other employee entitlements payable later than one year<br />
have been measured at the present value of the estimated future cash outflows to be made for those entitlements.<br />
(C) TAX STATUS<br />
The <strong>Institute</strong> has been endorsed as an income tax exempt charitable entity and a deductible gift recipient under<br />
provisions of the Income Tax Assessment Act 1997. Donations of $2 or more made to the <strong>Institute</strong> are tax deductible.<br />
(D) INCOME RECOGNITION<br />
Grant funding is recognised as income as the obligations under the funding agreement have been met.<br />
Unexpended Grants relating to specific projects are shown as a Current Liability in the Balance Sheet as the funds<br />
are not controlled.<br />
Donations are brought to account as revenue when they are received.<br />
Revenue from the rendering of a service is recognised upon the delivery of the service.<br />
Interest revenue is recognised on a proportional basis taking into account the interest rates applicable to the<br />
financial assets.<br />
Dividend revenue is recognised when the right to receive a dividend has been established.<br />
(E) CAPITAL FUNDS<br />
The Capital Reserves represents gains related to the recognition of the property at Oak Street, Parkville and in fixed<br />
assets of MHRI.<br />
(F) SPECIAL PURPOSE FUNDS<br />
Donations are brought to account as revenue when they are received. Where any specified obligations have not<br />
yet been met nor the relevant expenditure incurred, the unexpended balances have been transferred to special<br />
purpose funds.<br />
1. Directed donations fund<br />
These funds are held to be used in accordance with the wishes of the donors.<br />
2. Perpetual fund<br />
The Claudia Wright appeal is a perpetual fund in which the capital is maintained and the income derived is directed<br />
towards specified research at the <strong>Institute</strong>.<br />
3. Development reserve fund<br />
Funds raised by the <strong>Institute</strong> to maintain a capital base for ongoing research are held in a special purpose fund.<br />
Expenditure from this fund requires board approval.
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
(G) FINANCIAL ASSETS<br />
The <strong>Institute</strong> classifies its other investments in the following categories: held to maturity investments and available for<br />
sale investments. The classification depends on the purpose for which the investments were acquired. Management<br />
determines the classification of its investments at initial recognition.<br />
Held to maturity investments<br />
These investments have fixed maturities and it is the <strong>Institute</strong>’s intention to hold these investments to maturity.<br />
Investments are stated at amortised cost using the effective interest rate method.<br />
Available for sale financial assets<br />
Available for sale financial assets include any financial assets not included in the above category.<br />
Available for sale financial assets are reflected at fair value. Unrealised gains and losses arising from changes in fair<br />
value are taken directly to equity.<br />
The fair value of investments that are actively traded in organised financial markets is determined by reference to<br />
quoted bid prices at the close of business on the balance sheet date.<br />
(H) RECEIVABLES<br />
Debtors are recognised at the amount receivable and are due for settlement within the terms stated, usually thirty<br />
days from the end of the month in which the debt is recognised.<br />
(I) PAYABLES<br />
Creditors are paid according to <strong>Institute</strong> policy, currently within thirty days from the end of the month in which the<br />
liability is recognised.<br />
(J) GOODS & SERVICES TAX (GST)<br />
Revenues, expenses and assets are recognised net of the amount of GST, except where the amount of GST incurred<br />
is not recoverable from the Australian Tax Office. In these circumstances the GST is recognised as part of the cost of<br />
acquisition of the asset or as part of an item of expense. Receivables and payables in the Balance Sheet are shown<br />
inclusive of GST.<br />
(K) CASH AND CASH EQUIVALENTS<br />
Cash and cash equivalents include cash on hand, deposits held at call with banks, other short term high liquid<br />
investments with original maturities of three months or less.<br />
(L) LEASES<br />
Lease payments for operating leases, where substantially all the risks and benefits remain with the lessor, are charged<br />
as expenses in the periods in which they are incurred.<br />
67
68<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
(M) MEMBERS’ GUARANTEE<br />
The Company is limited by guarantee. If the company is wound up, the Constitution states that each member is<br />
required to contribute a maximum of $25 each towards meeting any outstanding obligations of the company.<br />
At 31 December 2010, the number of members was 30.<br />
(N) MONIES HELD IN TRUST - ACCOMMODATION AND RELOCATION GRANT<br />
The <strong>Institute</strong> is in receipt of an $8,000,000 grant from the Victorian government which is held in trust until the<br />
anticipated relocation to the Parkville medical precinct. Under the agreement, the <strong>Institute</strong> must hold this grant<br />
(and the compounding interest) for the sole purpose of accommodation and relocation. Should the anticipated<br />
relocation not take place, the <strong>Institute</strong> has agreed to a total refund to the Victorian government.<br />
Therefore, the accommodation and relocation grant (and the compounding interest) has not been recognised<br />
through the Income Statement.<br />
The <strong>Institute</strong> has applied funds which were held in trust for the relocation of the Cunningham Dax gallery to the<br />
Parkville medical precinct.<br />
(P) IMPAIRMENT OF ASSETS<br />
At each reporting date, the <strong>Institute</strong> reviews the carrying values of its tangible assets to determine whether there is<br />
any indication that those assets have been impaired. Where it is not possible to estimate the recoverable amount of<br />
an individual asset, the <strong>Institute</strong> estimates the recoverable amount of the cash-generated unit to which it belongs.<br />
(Q) CRITICAL ACCOUNTING ESTIMATES AND JUDGEMENT<br />
The Directors evaluate estimates and judgements incorporated into the financial report based on historical<br />
knowledge and best available current information. Estimates assume a reasonable expectation of future events and<br />
are based on current trends and economic data, obtained both externally and within the <strong>Institute</strong>.<br />
Key estimates - impairment<br />
The <strong>Institute</strong> assesses impairment at each reporting date by evaluating conditions specific to the institute that may<br />
lead to impairment of assets. Where an impairment trigger exists, the recoverable amount of the asset is determined.<br />
Value-in-use calculations performed in assessing recoverable amounts incorporate a number of key estimates.<br />
(R) COMPARATIVE FIGURES<br />
Where required by accounting standards, comparative figures have been adjusted to conform to changes in<br />
presentation for the current financial period.<br />
(S) ROUNDING<br />
The <strong>Institute</strong> has applied the relief available to it under ASIC Class Order 98/100 and accordingly, amounts in the<br />
financial report and Directors’ report have been rounded off to the nearest dollar.
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
(T) CHANGE IN ACCOUNTING PERIOD IN THE PRIOR PERIOD<br />
The <strong>Institute</strong> changed its financial reporting period from a balance date at 30 June to end the financial reporting<br />
period at 31 December in 2009. The Directors anticipated the revised financial reporting period would align the<br />
financial reports for the period with the operational outcomes. The comparative financial period covered by this<br />
financial report is for the six months beginning on 1 July 2009 and ending on 31 December 2009 to facilitate this<br />
change. ASIC granted an instrument of relief under s340(1) of the Corporations Act 2001 allowing the change in<br />
reporting period.<br />
(U) ACCOUNTING STANDARDS ISSUED NOT YET OPERATIVE<br />
The <strong>Institute</strong> has considered the potential future impact of relevant Australian Accounting Standards issued at the<br />
date of this report but not yet operative, and have determined the implementation of these Standards will not result<br />
in any material adjustments or changes to accounting policies.<br />
(V) EARLY ADOPTION OF ACCOUNTING STANDARDS<br />
The <strong>Institute</strong> has elected to adopt the Reduced Disclosure Requirements available through early adoption of AASB<br />
1053 and AASB 2010-2. The Reduced Disclosure Requirements aim to improve the relevance and clarity of<br />
financial reporting.<br />
69
70<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
NOTE 2: INCOME<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
(A) GRANT INCOME - GOVERNMENT & STATUTORY BODIES<br />
(1) State Government Grants<br />
(i) Operating grants<br />
Brought forward from previous period 161,566 -<br />
Received in current period 2,626,605 1,178,430<br />
Capital commitment - -<br />
Less carried forward to next period - (161,566)<br />
2,788,171 1,016,864<br />
(ii) Project grants<br />
Brought forward from previous period 15,280 15,280<br />
Received in current period 96,664 47,585<br />
Less carried forward to next period (15,280) (15,280)<br />
96,664 47,585<br />
Total State Government Grants 2,884,835 1,064,449<br />
The <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> was supported by the Victorian Government’s operational infrastructure support program.<br />
We received income of $628,266 from the program in the year and spent these funds in support of operational infrastructure.<br />
(2) Federal Government Grants<br />
(i) Project grants<br />
Brought forward from previous period 62,310 453,958<br />
Received in current period 4,913,833 1,717,476<br />
Less grants received in advance carried forward to next period (150,000) (62,310)<br />
4,826,143 2,109,124<br />
(ii) Postgraduate research grants<br />
Received in current period - -<br />
Total Federal Government Grants 4,826,143 2,109,124
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
(3) Other Grants<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
Brought forward from previous period - -<br />
Received in current period 227,069 199,742<br />
Less carried forward to next period - -<br />
Total Other Grants 227,069 199,742<br />
TOTAL GRANTS 7,938,047 3,373,315<br />
(B) PUBLIC SUPPORT INCOME<br />
Donations and bequests as listed in this report are allocated<br />
and used in accordance with the wishes of the donors.<br />
- Unspecified donations 304,986 138,871<br />
- Directed donations 894,338 346,354<br />
- Foundation funds 166,428 109,093<br />
- Perpetual fund donations 302,037 -<br />
- Sales 6,618 4,251<br />
- Other Dax Gallery 223,278 -<br />
TOTAL PUBLIC SUPPORT INCOME 1,897,685 598,56<br />
(C) LAND ASSET RECOGNISED ON TRANSFER OF RESPONSIBILTY<br />
Land at 155 Oak Street 8,981,000 -<br />
The <strong>Institute</strong> was appointed Committee of Management over the<br />
Crown Land site at 155 Oak Street, Parkville. The land is recognised<br />
as an asset of the <strong>Institute</strong>, as the <strong>Institute</strong> has responsibility for the site.<br />
(D) RELOCATION GRANT INCOME<br />
Grant received for Dax Relocation and interest received on<br />
invested funds 2,024,660 -<br />
Income received in a prior period specifically for the purpose<br />
of relocating the Dax Collection to a new building. Income is now<br />
recognised as the funds have been expended for the specified purpose.<br />
71
72<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
NOTE 3: NON- OPERATING<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
(A) AUDITORS REMUNERATION<br />
Remuneration of auditor<br />
- auditing the accounts 13,500 10,500<br />
(B) DEPRECIATION<br />
Buildings and building improvements 328,876 156,347<br />
Equipment, furniture and fittings 60,742 23,750<br />
Scientific assets 549,037 238,091<br />
NOTE 4: CASH AND CASH EQUIVALENT ASSETS<br />
NOTE 5: TRADE AND OTHER RECEIVABLES<br />
NOTE 5(A): STOCK<br />
Total depreciation 938,655 418,188<br />
Cash on hand 2,499 1,831<br />
Cash at bank 433,892 326,300<br />
Cunningham Dax gallery cash at bank 137,885 45,035<br />
574,276 373,166<br />
Trade debtors 710,481 637,784<br />
Less provision for doubtful debts - -<br />
Accrued income 681,790 20,845<br />
Other debtors 35,856 111,031<br />
1,428,127 769,660<br />
Stock on Hand 23,287 -<br />
23,287 -
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
NOTE 6: FINANCIAL ASSETS<br />
CURRENT<br />
NON-CURRENT<br />
NOTE 7: PROPERTY, PLANT AND EQUIPMENT<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
Term deposits at cost 5,068,523 4,545,126<br />
5,068,523 4,545,126<br />
Cunningham Dax relocation account - 3,132,430<br />
Shares in listed corporations, at fair value 159,658 163,622<br />
MHRI accommodation relocation account 10,688,031 10,047,226<br />
The <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> occupies premises situated<br />
at 155 Oak Street, Parkville, Victoria 3052 on Crown Land gazetted<br />
as a <strong>Mental</strong> <strong>Health</strong> Reserve.<br />
(A) CONTROLLED AS COMMITTEE OF MANAGEMENT<br />
10,847,689 13,343,278<br />
Land at fair value 8,981,000 -<br />
Buildings and improvements at fair value 5,016,000 5,880,158<br />
Less accumulated depreciation (1,335,000) (4,441,165)<br />
Fair value for land and buildings controlled as Committee<br />
of Management is based on the value advised by the<br />
Department of <strong>Health</strong> at the time of delegation of responsibilty.<br />
3,681,000 1,438,993<br />
73
74<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
(B) ASSETS UNDER CONSTRUCTION<br />
(C) OWNED ASSETS<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
Dax Collection at the Melbourne Brain Centre 4,357,202 -<br />
The Melbourne Brain Centre is a collaboration between<br />
the <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong>, the University of Melbourne,<br />
the Florey Neuroscience <strong>Institute</strong>s, Austin <strong>Health</strong> and Melbourne <strong>Health</strong>.<br />
The <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> has received grant funding<br />
to assist with the construction and relocation to the new site (refer Note 11).<br />
During the year, construction of the new premises for the Dax<br />
Collection commenced, but the Collection has not yet been relocated.<br />
Equipment, furniture and fittings at cost 470,597 419,743<br />
Less accumulated depreciation (326,766) (266,024)<br />
143,831 153,719<br />
Scientific equipment at cost 2,992,860 2,252,654<br />
Less accumulated depreciation (1,667,888) (1,118,851)<br />
1,324,972 1,133,803<br />
TOTAL PROPERTY, PLANT AND EQUIPMENT 18,488,005 2,726,515
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
(D) MOVEMENT IN CARRYING AMOUNTS<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
Building Building under Equipment Scientific Total<br />
Land & improvements construction furniture & fittings equipment<br />
Carrying Amount 1 Jan 2010 - 1,438,993 - 153,719 1,133,803 2,726,515<br />
Additions - 44,500 4,357,202 50,854 740,206 5,192,762<br />
Disposals - - - - - -<br />
Depreciation - (328,876) - (60,742) (549,037) (938,655)<br />
Recognised as controlled asset 8,981,000 - - - - 8,981,000<br />
Revaluation to Fair Value - 2,526,383 - - - 2,526,383<br />
Impairment - - - - - -<br />
Carrying Amount 31 Dec 2010 8,981,000 3,681,000 4,357,202 143,831 1,324,972 18,488,005<br />
(E) SCIENTIFIC EQUIPMENT<br />
Scientific equipment purchased during the year to 31 December 2010<br />
above $2000 has been capitalised and depreciated in accordance with the policy<br />
described in Note 1(A). Purchases under this amount have been expensed<br />
through the Income Statement. 75,004 30,763<br />
75
76<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
NOTE 8: TRADE AND OTHER PAYABLES<br />
NOTE 9: UNEXPENDED PROJECT GRANTS<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
Trade creditors and accruals 2,575,436 299,039<br />
2,575,436 299,039<br />
GST, Superannuation and PAYG Liability 301,472 348,794<br />
301,472 348,794<br />
2,876,908 647,833<br />
State Government Project Grants - 161,566<br />
Federal Government Project Grants 150,000 62,310<br />
Other Grants - -<br />
NOTE 10: PROVISIONS FOR EMPLOYEE BENEFITS<br />
CURRENT<br />
NON-CURRENT<br />
150,000 223,876<br />
Employee entitlements - annual leave 475,393 578,833<br />
Employee entitlements - long service leave 298,746 264,973<br />
Employee entitlements - employee benefits 3,643 15,000<br />
777,782 858,806<br />
Employee entitlements - long service leave 73,318 69,076
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
NOTE 11: UNEXPENDED RELOCATION GRANT<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
MHRI Accommodation relocation account<br />
Trust funds invested 8,000,000 8,000,000<br />
Interest received 2,391,216 2,043,814<br />
Term deposit 10,391,216 10,043,814<br />
Interest accrued 296,815 3,412<br />
Total unexpended / (shortfall) 10,688,031 10,047,226<br />
Cunningham Dax relocation account<br />
Trust Funds invested 2,900,000 2,900,000<br />
Interest received 391,153 269,203<br />
Term deposit 3,291,153 3,169,203<br />
Cash Held - 2,751<br />
Costs of construction and relocation (4,423,695) (66,500)<br />
Interest accrued - 26,976<br />
Total unexpended / (shortfall) (1,132,542) 3,132,430<br />
The shortfall in construction costs is included in trade creditors at 31 December 2010.<br />
The Dax shortfall is to be paid from <strong>Health</strong> and Hospitals Fund contributions.<br />
In the event this funding is unavailable, MHRI has underwritten to cover the Dax relocation.<br />
77
78<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
NOTE 12: RESERVES<br />
(A) CAPITAL FUND 1(E)<br />
(B) ASSET REVALUATION RESERVE<br />
(C) ACCUMULATED RESEARCH FUNDS<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
Balance at the beginning of the period 5,713,141 5,713,141<br />
Transfers to/from Capital Fund 1,200,000 -<br />
Transfer from Accumulated Deficit/Surplus 11,005,660 -<br />
Balance at the end of the financial period 17,918,801 5,713,141<br />
Balance at the beginning of the period - -<br />
Revaluation of buildings and improvements - 155 Oak St, Parkville 2,526,383 -<br />
Balance at the end of the financial period 2,526,383 -<br />
(i) Directed Donations/Interest and <strong>Research</strong> Funds<br />
Balance at the beginning of the period 2,622,738 2,641,811<br />
Transfers to/from reserves 50,882 (19,073)<br />
Transfer from Accumulated Deficit/Surplus (1,485,204) -<br />
Balance at the end of the financial period 1,188,416 2,622,738<br />
Represented by :<br />
<strong>Research</strong> and General Reserves 1,136,406 2,614,894<br />
Claudia Wright Interest Fund 12(iii) 52,010 7,844<br />
Balance at the end of the financial period 1,188,416 2,622,738
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
NOTE 13: ACCUMULATED SURPLUS<br />
(ii) Perpetual Fund<br />
Claudia Wright Perpetual Fund<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
Balance at the beginning of the financial period 176,664 176,664<br />
Donations - -<br />
Balance at the end of the financial period 176,664 176,664<br />
1,365,080 2,799,402<br />
(iii) Movement in Claudia Wright Interest Fund<br />
(included in Directed Donations & Interest Fund)<br />
Balance at the beginning of the financial period 7,844 6,300<br />
Interest Received 14,191 6,044<br />
Salaries Paid - (4,500)<br />
Expenses Paid - -<br />
Balance at the end of the financial period 22,035 7,844<br />
Accumulated surplus at the beginning of the financial period (1,800,113) (1,266,404)<br />
Adjustment due to change in accounting policy - -<br />
Net surplus for the period 11,320,569 (533,709)<br />
Transfer from Accumulated Deficit/Surplus (9,520,456) -<br />
Transfer to perpetual fund - -<br />
Accumulated surplus at the end of the financial period - (1,800,113)<br />
NOTE 14: LEASING AND CAPITAL COMMITMENTS<br />
Operating lease commitments - motor vehicles<br />
Aggregate lease expenditure contracted at balance date<br />
but not provided for in the accounts<br />
Not later than 1 year 35,429 27,112<br />
Later than 1 year and not later than 2 years 28,958 15,090<br />
Later than 2 years and not later than 5 years 7,202 8,400<br />
Total lease commitments 71,589 50,602<br />
79
80<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
NOTE 15: EXECUTIVE REMUNERATION<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
(A) Remuneration of Board Members - -<br />
The names of each person who held office as a Board Member of The <strong>Mental</strong> <strong>Health</strong><br />
<strong>Research</strong> <strong>Institute</strong> during the financial period ended 31 December 2010 are:<br />
Dr Sandra Hacker Professor Colin Masters<br />
Mr Trevor Clark Professor Steve Wesselingh<br />
Professor James Angus Professor Ingrid Winship<br />
Mr Rob Gerrand Mr Andrew Stripp<br />
Ms Jennifer Labourne Ms Katarina Klaric<br />
No Board Member has received or has become entitled to receive any benefit from the <strong>Institute</strong>,<br />
apart from Executive Director Professor Colin Masters who receives remuneration in respect<br />
of his employment as Executive Director.<br />
(B) Remuneration of Key Management Personnel<br />
Aggregate remuneration paid or<br />
payable to key management personnel 1,855,545 898,916<br />
Key management personnel are comprised of a Senior Executive Committee<br />
which includes; the Executive Director, the Chief Operating Officer,<br />
the Laboratory Facilities Manager, five Laboratory Heads,<br />
the Development Manager and the Accountant.
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
NOTE 16: CASH FLOW INFORMATION<br />
(A) RECONCILIATION OF CASH<br />
12 months 6 months<br />
to 31 Dec 10 to 31 Dec 09<br />
$ $<br />
Cash on hand 2,491 1,831<br />
Cash at bank 433,899 326,300<br />
Cunningham Dax Gallery cash at bank 137,886 45,035<br />
(B) RECONCILIATION OF NET CASH PROVIDED BY OPERATING ACTIVITIES TO NET SURPLUS<br />
574,276 373,166<br />
Net surplus / (deficit) 11,320,569 (533,709)<br />
Non-cash flows in surplus:<br />
Recognition of land asset on transfer of Committee of Management (8,981,000) -<br />
Relocation grant income received in a prior period (2,024,660) -<br />
Depreciation 938,655 418,188<br />
Provision for doubtful debts - -<br />
Changes in assets and liabilities:<br />
Decrease (increase) in receivables (651,026) (127,726)<br />
Increase (decrease) in trade and other payables 100,456 1,419<br />
(Decrease) increase in unexpended grants and relocation accounts (73,876) (249,156)<br />
Increase in provisions for employee benefits (76,782) 10,185<br />
Cash flows from operating activities 552,336 (480,799)<br />
81
82<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2010 - Continued.<br />
NOTE 17: EVENTS SUBSEQUENT TO BALANCE DATE<br />
The Cunningham Dax has incorporated as a separate entity in preparation for separation from<br />
The <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong>. Within the next 12 months, the assets of the Cunningham<br />
Dax Collection managed by the <strong>Institute</strong>, together with relevant liabilities, will be transferred to<br />
the new entity.<br />
The following table indicates the impact of the transfer on the <strong>Institute</strong>.<br />
MHRI Dax Collection Total<br />
Statement of Comprehensive Income 2010<br />
Income $11,951,903 $701,856 $12,653.759<br />
Expenses -$11,652,626 -$686,224 -$12,338,850<br />
Net surplus / (deficit) $ 299,277 $ 314,909<br />
Balance Sheet as at 31 December 2010<br />
Total assets $35,642,412 $787,495 $36,429,907<br />
Total liabilities -$14,566,039 - -$14,566,039<br />
Net assets $21,076,373 $787,495 $21,863,868<br />
Cash Flow Statement 2010<br />
Net cash provided by operating activities $536,704 $15,632 $552,336<br />
Net cash from financing activities $ - - -$351,226<br />
Net increase / (decrease) in cash held $536,704 $15,632 $201,110<br />
There were no other events since balance date which<br />
significantly affected or may significantly affect the operations<br />
of the <strong>Institute</strong>, the results of those operations or the state of<br />
the <strong>Institute</strong> in future years.
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
DIRECTORS’ DECLARATION<br />
The Directors of the company declare that:<br />
(1) The financial statements and notes, as set out on pages 56 to 86 are in accordance with the Corporations Act 2001:<br />
(a) comply with Accounting Standards Reduced Disclosure Requirements and the Corporations Regulations 2001;<br />
and<br />
(b) give a true and fair view of the <strong>Institute</strong>’s financial position as at 31 December 2010 and of its performance<br />
for the year ended on that date.<br />
(2) In the Directors’ opinion there are reasonable grounds to believe that the <strong>Institute</strong> will be able to pay its debts as<br />
and when they become due and payable.<br />
This declaration is made in accordance with a resolution of the Board of Directors.<br />
S Hacker AO<br />
Chair<br />
Signed at Melbourne on the 11th April, 2011.<br />
83
84<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
INDEPENDENT AUDITOR’S REPORT TO THE MEMBERS OF THE MENTAL HEALTH RESEARCH INSTITUTE<br />
<strong>Report</strong> on the financial report<br />
We have audited the accompanying financial report of The <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> (the company), which comprises<br />
the Balance Sheet as at 31 December 2010, and the Statement of Comprehensive Income, Statement of Changes in Equity<br />
and Cash Flow Statement for the year ended on that date, a summary of significant accounting policies and other explanatory<br />
notes and the Directors’ Declaration.<br />
Directors’ responsibility for the financial report<br />
The directors of the company are responsible for the preparation and fair presentation of the financial report in accordance<br />
with Australian Accounting Standards - Reduced Disclosure Requirements and the Corporations Act 2001 and for such internal<br />
control as the directors determine is necessary to enable the preparation of the financial report that is free from material<br />
misstatement, whether due to fraud or error.<br />
Auditor’s responsibility<br />
Our responsibility is to express an opinion on the financial report based on our audit. We conducted our audit in accordance<br />
with Australian Auditing Standards. Those Standards require that we comply with relevant ethical requirements relating to<br />
audit engagements and plan and perform the audit to obtain reasonable assurance whether the financial report is free<br />
from material misstatement.<br />
An audit involves performing procedures to obtain audit evidence about the amounts and disclosures in the financial report.<br />
The procedures selected depend on the auditor’s judgment, including the assessment of risks of material misstatement of the<br />
financial report, whether due to fraud or error. In making those risk assessments, the auditor considers internal control relevant to<br />
the entity’s preparation of the financial report that gives a true and fair view in order to design audit procedures that are<br />
appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the entity’s internal<br />
control. An audit also includes evaluating the appropriateness of accounting policies used and the reasonableness of<br />
accounting estimates made by the directors, as well as evaluating the overall presentation of the financial report.<br />
We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our audit opinion.<br />
Matters Relating to the Electronic Publication of the Audited Financial <strong>Report</strong><br />
This auditor’s report relates to the financial report of The <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> for the year ended 31 December 2010<br />
included on the <strong>Institute</strong>’s website. The company’s directors are responsible for the integrity of the <strong>Institute</strong>’s website.<br />
We have not been engaged to report on the integrity of the <strong>Institute</strong>’s website. The auditor’s report refers only to the subject<br />
matter described above. It does not provide an opinion on any other information which may have been hyperlinked to/from<br />
these statements. If users of the financial report are concerned with the inherent risks arising from publication on a website, they<br />
are advised to refer to the hard copy of the financial report to confirm the information contained in this website version of the<br />
financial report.
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
Independence<br />
In conducting our audit, we have complied with the independence requirements of the Corporations Act 2001.<br />
We confirm that the independence declaration required by the Corporations Act 2001, which has been given to the directors<br />
of the company, would be in the same terms if given to the directors as at the time of this auditor’s report.<br />
Audit Opinion<br />
In our opinion, the financial report of The <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> is in accordance with the Corporations<br />
Act 2001 including:<br />
(i) giving a true and fair view of the <strong>Institute</strong>’s financial position as at 31 December 2010 and of its<br />
performance for the year ended on that date; and<br />
(ii) complying with Australian Accounting Standards - Reduced Disclosure Requirements and the<br />
Corporations Regulations 2001.<br />
UHY Haines Norton Joella Gould<br />
Chartered Accountants Partner<br />
Signed<br />
Melbourne<br />
Dated this the 11th day of April 2011.<br />
Liability limited by a scheme approved under Professional Standards legislation.<br />
85
86<br />
Audited Financial Statements<br />
for the year ended 31 December 2010<br />
AUDITOR’S INDEPENDENCE DECLARATION<br />
TO THE BOARD OF DIRECTORS OF THE MENTAL HEALTH RESEARCH INSTITUTE<br />
I declare that, to the best of my knowledge and belief, during the year ended 31 December 2010, there have been:<br />
(i) no contraventions of the auditor independence requirements as set out in the Corporations Act 2001 in relation<br />
to the audit: and<br />
(ii) no contraventions of any applicable code of professional conduct in relation to the audit.<br />
Joella F Gould<br />
Partner<br />
UHY Haines Norton<br />
Chartered Accountants<br />
Dated this the 11th day of April 2011.<br />
Liability limited by a scheme approved under Professional Standards Legislation.
Personnel<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Rebecca L Cooper Laboratory<br />
Head of Laboratory / NHMRC Senior<br />
<strong>Research</strong> Fellow<br />
Professor Brian Dean HND ApplBiol,<br />
MSc, PhD, Fl Biol<br />
Head of Muscarinic Receptor Group /<br />
Royce Abbey Postdoctoral Fellow<br />
Dr Elizabeth Scarr BSc (Hons), PhD<br />
<strong>Research</strong> Officers<br />
Dr Andrew Gibbons BSc (Hons), PhD<br />
Dr Madhara Udawela BSc (Hons), PhD<br />
Dr Jung Yoon Um BSc, PhD<br />
Graduate <strong>Research</strong> Assistant<br />
Geoffrey Pavey BSc (Hons)<br />
Doctoral Students<br />
Tammie Money BSc (Hons)<br />
Nahed Tawadros BSc (Hons)<br />
Ajeet Singh (MBBS)<br />
Myoung Suk Seo BSc, MSc<br />
Won Je Jeon BSc, MSc<br />
Masters Students<br />
Lucy Brooks (BSc)<br />
Collaborators<br />
Dr Andrew Aquilina<br />
(University of Woolongong)<br />
Professor Michael Berk<br />
(Barwon <strong>Health</strong> and The Geelong<br />
Clinic, The University of Melbourne)<br />
Dr Olivia Dean<br />
(Barwon <strong>Health</strong> and The Geelong<br />
Clinic, The University of Melbourne)<br />
Professor Ian Everall (Cato Chair of<br />
Psychiatry, The University of Melbourne)<br />
Professor Vahram Haroutunian<br />
(Mount Sinai School of Medicine,<br />
New York, NY, USA)<br />
Professor James Meadow-Woodruff<br />
(Department of Psychiatry and<br />
Behavioral Neurobiology, University of<br />
Alabama at Birmingham, USA)<br />
Dr Robert McCullumsmith (Department<br />
of Psychiatry and Behavioral<br />
Neurobiology, University of Alabama<br />
at Birmingham, USA)<br />
Professor Christos Pantelis (Melbourne<br />
Neuropsychiatry Centre, The University<br />
of Melbourne)<br />
Dr Victoria Perreau (Centre for<br />
Neuroscience, The University of<br />
Melbourne)<br />
Dr Elizabeth Thomas (The Scripps<br />
<strong>Research</strong> <strong>Institute</strong>, California, USA)<br />
Takeo Yoshikawa (RIKEN)<br />
Behavioural Neuroscience<br />
Laboratory<br />
Head of Laboratory<br />
Associate Professor Maarten van den<br />
Buuse BSc (Hons), PhD<br />
Postdoctoral Scientists<br />
Dr Andrea Gogos BSc (Hons), PhD<br />
Dr Rachel Hill BSc (Hons), PhD<br />
Dr Paul Halley BSc (Hons), PhD<br />
(Until March 2010)<br />
Dr Sue Tye BSc (Hons), PhD<br />
(Deakin University) (from June 2010)<br />
<strong>Research</strong> Assistants<br />
Sally Martin BSc (Hons)<br />
Perrin Kwek BSc (Hons)<br />
Angela Hurley BSc<br />
PhD Students<br />
Maren Klug BSc (Hons)<br />
Shane Thwaites BSc (Hons)<br />
Yee Wen Candace Wu BSc (Hons)<br />
Elizabeth Manning BSc (Hons)<br />
(From July 2010)<br />
Honours student<br />
Jac Kee Low BSc<br />
Visiting Students<br />
Emma Ruimschotel BSc (Netherlands)<br />
(Until June 2010)<br />
Maaike Labots BSc (Netherlands)<br />
(Until March 2010)<br />
Ger Post BSc (Netherlands)<br />
Collaborators<br />
Professor Ashley Bush<br />
(<strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong>)<br />
Professor Michael Berk<br />
(The University of Melbourne)<br />
Dr Tony Hannan<br />
(Howard Florey <strong>Institute</strong>, Melbourne)<br />
Dr Nigel Jones<br />
(Royal Melbourne Hospital, Melbourne)<br />
Professor Terence O’Brien<br />
(Royal Melbourne Hospital, Melbourne)<br />
Dr Simon Murray<br />
(The University of Melbourne)<br />
Dr Jeff Craig<br />
(Murdoch Childrens <strong>Research</strong> <strong>Institute</strong>)<br />
Dr Sue Tye (Deakin University)<br />
Dr Manfred Gerlach<br />
(University of Wurzburg, Germany)<br />
87
88<br />
Personnel<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Molecular Psychopharmacology<br />
Laboratory<br />
Head<br />
Associate Professor Suresh Sundram<br />
MBBS, MMed, FRANZCP, PhD<br />
Senior Scientist Honorary Professorial<br />
Fellow<br />
Professor George Fink MBBS, DPhil,<br />
MD, FRCPE, FRSE<br />
Senior <strong>Research</strong> Officer<br />
Dr Avril Pereira BAppSc, MSc, PhD<br />
<strong>Research</strong> Assistant<br />
Peter Malcolm BSc (Hons)<br />
PhD Students<br />
Sujeevan Sinnatamby MD, FRANZCP<br />
Vaidy Swaminathan MD, FRANZCP<br />
(until February 2010)<br />
Advanced Medical Sciences (AMS)<br />
Students<br />
Yuanna Zhou<br />
Honam Choi<br />
Postgraduate Student<br />
Hanneke Raaijmakers<br />
Northern Psychiatry <strong>Research</strong><br />
Centre<br />
Head<br />
Associate Professor Suresh Sundram<br />
MBBS, MMed, FRANZCP, PhD<br />
Senior <strong>Research</strong> Physician<br />
Dr Russell D’Souza MPM, MD<br />
<strong>Research</strong> Coordinator<br />
Fiona Bole RN<br />
<strong>Research</strong> Nurse<br />
Sumathy Sathiyamoorthy RN (Div II)<br />
<strong>Research</strong> Physician<br />
Dr Rohit Lodhi MD, MRCPsych<br />
PhD Student<br />
Jody Stanley<br />
Postgraduate Students<br />
Lydia Brown<br />
Sarah Arnold<br />
Advanced Medical Sciences (AMS)<br />
Students<br />
Zexi Allan<br />
Collaborators<br />
Professor Michael Berk<br />
(The University of Melbourne)<br />
Dr Olivia Carter<br />
(The University of Melbourne)<br />
Dr Gursh Chana<br />
(The University of Melbourne)<br />
Ms Tiffany Cowie<br />
(The University of Melbourne)<br />
Dr Peter Crouch<br />
(The University of Melbourne)<br />
Professor Brian Dean<br />
(<strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong>)<br />
Dr Seetal Dodd<br />
(The University of Melbourne)<br />
Professor Ian Everall<br />
(The University of Melbourne)<br />
Dr John Farhall (La Trobe University)<br />
Ms Marnie Graeco (Northern Hospital)<br />
Professor Brenda Happell<br />
(Central Queensland University)<br />
Ms Alison Harrington<br />
(Northern Area <strong>Mental</strong> <strong>Health</strong> Service)<br />
Dr Alexander Holmes<br />
(The University of Melbourne)<br />
Dr Ana Hutchinson<br />
(Northern Clinical <strong>Research</strong> Centre)<br />
Dr Nigel Jones<br />
(The University of Melbourne)<br />
Dr Gerard Kennedy (Victoria University)<br />
Dr Ken McAnally (Defense Science<br />
Technology Organization)<br />
Professor Ralph Martins (Edith Cowan<br />
University)<br />
Professor Terence O’Brien<br />
(The University of Melbourne)<br />
Dr Meaghan O’Donnell<br />
(The University of Melbourne)<br />
Dr Elizabeth Scarr<br />
(The University of Melbourne)<br />
Dr Elizabeth Thomas<br />
(Scripps <strong>Institute</strong>, USA)<br />
Professor Cyndi Shannon-Weickert<br />
(Prince of Wales Medical<br />
<strong>Research</strong> <strong>Institute</strong>)<br />
Dr Anthony White<br />
(The University of Melbourne)
Personnel<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Neuropathology<br />
Head (Group Leader)<br />
Professor Colin Masters<br />
Post-doctoral Scientists<br />
Dr Blaine Roberts BSc, PhD<br />
Dr Tim Ryan BSc (Hons), PhD<br />
Dr Qiao-Xin Li BSc, PhD<br />
Dr Scott Lafoon BSc, PhD<br />
<strong>Research</strong> Assistants<br />
Monica Lind BChemEng, MBiotech<br />
Kathryn Jones-Ganio BSc<br />
Katrina Laughton BSc<br />
Collaborators<br />
National Collaborators:<br />
Dr Tara Pukala,<br />
(Adelaide University, Adelaide, SA)<br />
International Collaborators:<br />
Professor Edward A. Dratz (Montana<br />
State University, Bozeman, MT)<br />
Oxidation Biology Laboratory<br />
Head of Laboratory<br />
Professor Ashley Bush MBBS, DPM,<br />
PhD, FRANZCP, FTSE<br />
Principal <strong>Research</strong> Fellow and Deputy Head<br />
Associate Professor Robert Cherny<br />
BSc, PhD<br />
Personal & Administrative Assistant<br />
Suzie McNicol Dip Fin Plan<br />
Senior <strong>Research</strong> Fellow<br />
Dr Paul Adlard BSc (Hons), PhD<br />
Associate Professor Robert Cherny<br />
BSc, PhD<br />
Associate Professor David Finkelstein<br />
BSc, GradDip, MSc, PhD<br />
Dr James Duce BSc (Hons), PhD<br />
<strong>Research</strong> Fellows and Post-doctoral<br />
Scientists<br />
Dr Ya Hui Hung BMus, BSc (Hons), PhD<br />
Dr Chris Lim BSc (Hons), PhD<br />
Dr Gawain McColl BSc (Hons), PhD<br />
Dr Lynda O’Sullivan BSc (Hons), PhD<br />
Dr Alan Rembach BSc (Hons), PhD<br />
<strong>Research</strong> Officer<br />
Dr Toni Lynch BAppSc, MSc, PhD<br />
<strong>Research</strong> Assistants<br />
Andrew Dalziel, BA, BSc (Hons)<br />
Gulay Filiz BSc (Hons)<br />
Jessica George BSc (Hons), MSc<br />
Lydia Gunawan MappSc<br />
Linh Lam BSc (Hons)<br />
Xiang Liu BSc<br />
Elysia Robb BMedSc (Hons)<br />
Amelia Sedjahtera BSc (Hons)<br />
Andrew Tsatsanis BSc (Hons) (until<br />
June 2010)<br />
Irene Volitakis BSc (Hons)<br />
Helena Kim BSc (Hons)<br />
Varsha Lal BSc, BEng (Hons),<br />
PostgradDipMngt<br />
Amelia Sedjahtera BSc (Hons)<br />
Technical Assistants<br />
Lisa Bray AssocDipAppSc (AnimTech)<br />
Nicole Critch (DipAnimTech)<br />
Bruce Etherton, Animal Technician<br />
Sarah Evans (DipAnimTech)<br />
Rinola Singh (DipAnimTech)<br />
Postgraduate Students<br />
Scott Ayton BBNSc (Hons)<br />
Yif’at Biran BPharmSci, CertIV BusMgt,<br />
BSc (Hons)<br />
Mark Greenough BSc<br />
Adam Gunn BSc (Hons)<br />
Simon James BSc (Hons)<br />
Peng Lei BSc<br />
Rebecca Vaughan BSc (Hons)<br />
Visiting Students<br />
Daniela Zuser (IMC University of<br />
Applied Sciences, Krems, Austria)<br />
Elisa Arthofer (IMC University of Applied<br />
Sciences, Krems, Austria)<br />
National Collaborators<br />
Professor James Camakaris<br />
(Department of Genetics, The University<br />
of Melbourne)<br />
Dr Roger Chung<br />
(University of Tasmania)<br />
Dr Tracey Dickson<br />
(University of Tasmania)<br />
Dr Philip Doble<br />
(University of Technology, Sydney)<br />
Dr John Forsythe (Materials<br />
Engineering, Monash University)<br />
Professor Brett Garner (Illawarra <strong>Health</strong><br />
and Medical <strong>Research</strong> <strong>Institute</strong>,<br />
University of Wollongong)<br />
89
90<br />
Personnel<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Dr Melissa Gresle (Multiple Sclerosis<br />
Group, Howard Florey <strong>Institute</strong>)<br />
Professor Trevor Kilpatrick<br />
(Centre for Neuroscience/Howard<br />
Florey <strong>Institute</strong>, Melbourne)<br />
Professor Ralph Martins<br />
(University of Western Australia)<br />
Professor Julian FB Mercer<br />
(Director, Centre for Cellular and<br />
Molecular Biology, School of Biological<br />
and Chemical Sciences, Deakin<br />
University, Burwood)<br />
Associate Professor Christina Morganti-<br />
Kossmann (The Alfred, Melbourne)<br />
Dr David Nisbet (Materials Engineering,<br />
Monash University)<br />
Dr Melanie Pritchard (Department of<br />
Biochemistry and Molecular Biology,<br />
Monash University)<br />
Dr Tara Pukala (University of Adelaide)<br />
Professor James Vickers<br />
(University of Tasmania)<br />
Professor Adrian West<br />
(University of Tasmania)<br />
International Collaborators<br />
United States of America<br />
Professor Julie Anderson (Buck <strong>Institute</strong><br />
for Age <strong>Research</strong>, Novato, CA)<br />
Dr Math Cuajungco (Massachusetts<br />
General Hospital and Harvard Medical<br />
School, Boston, MA)<br />
Dr M Flint Beal (Cornell University,<br />
New York, NY)<br />
Professor Joseph S Beckman<br />
(Linus Pauling <strong>Institute</strong>, Corvallis, OR)<br />
Professor Edward A Dratz (Montana<br />
State University, Bozeman, MT)<br />
Dr Jane Flinn<br />
(George Mason University, Fairfax VA)<br />
Dr Jonathan Fox (Neurology,<br />
Massachusetts General Hospital,<br />
Boston, MA)<br />
Dr Avi Friedlich (Bedford Veterans<br />
Affairs Hospital, Boston, MA)<br />
Dr Lee Goldstein (Brigham and<br />
Women’s Hospital, Harvard Medical<br />
School, Boston, MA)<br />
Professor Elizabeth Head<br />
(University of Kentucky, Lexington, KY)<br />
Assistant Professor Xudong Huang<br />
(Department of Psychiatry,<br />
Massachusetts General Hospital,<br />
Boston, MA)<br />
Dr Deepinder Kaur (Buck <strong>Institute</strong> for<br />
Age <strong>Research</strong>, Novato, CA)<br />
Dr Mahmoud Kiaei (Weill Medical<br />
College of Cornell University,<br />
New York, NY)<br />
Dr Lenore Launer (National <strong>Institute</strong> on<br />
Aging, Bethesda, MD)<br />
Associate Professor Christopher D Link<br />
(<strong>Institute</strong> for Behavioral Genetics;<br />
University of Colorado, Boulder, CO)<br />
Associate Professor Gordon J Lithgow<br />
(Buck <strong>Institute</strong> for Age <strong>Research</strong>,<br />
Novato, CA)<br />
Associate Professor Simon Melov<br />
(Buck <strong>Institute</strong> for Age <strong>Research</strong>,<br />
Novato, CA)<br />
Associate Professor Martha Clare Morris<br />
(Rush <strong>Institute</strong> for <strong>Health</strong>y Aging, Rush<br />
University Medical Center, Chicago, IL)<br />
Dr Dan Ory (Washington University<br />
School of Medicine, St Louis)<br />
Associate Professor Michael Petris<br />
(Department of Biochemistry,<br />
University of Missouri-Columbia, MO)<br />
Associate Professor Jack Rogers<br />
(Psychiatry, Massachusetts General<br />
Hospital, Boston, MA)<br />
Professor Rudolph Tanzi (Director,<br />
Genetics and Aging <strong>Research</strong> Unit<br />
at Massachusetts General <strong>Institute</strong> for<br />
Neurodegenerative Disease,<br />
Boston, MA)<br />
Assistant Professor Robert Moir<br />
(Massachusetts General Hospital &<br />
Harvard Medical School, Boston, MA)<br />
Professor Dennis Thiele (Duke University<br />
Medical Center, Durham, NC)<br />
Dr Hui Zheng (Baylor College of<br />
Medicine, Houston, Texas)<br />
United Kingdom<br />
Dr Janet Johnston (Division of<br />
Psychiatry and Neuroscience, Queen’s<br />
University, Belfast, Ireland)<br />
Dr Craig W. Ritchie<br />
(Royal Free & University College<br />
Medical School, Hampstead)<br />
Professor Robert Evans<br />
(School of <strong>Health</strong> Sciences and Social<br />
Care, Brunel University, West London)<br />
Chile<br />
Professor Nibaldo Inestrosa,<br />
(Catholic University of Chile, Santiago)<br />
Dr Carlos Opazo (University of<br />
Concepcion)
Personnel<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Republic of Korea<br />
Professor Jae Koh (University of Ulsan<br />
College of Medicine, Seoul)<br />
Assistant Professor Joo-Yong Lee<br />
(University of Ulsan College of<br />
Medicine, Seoul)<br />
Japan<br />
Assistant Professor Yoichi Kato<br />
(University of Hyogo)<br />
Dr Seiichi Nagano (Harvard<br />
Medical School, Massachusetts<br />
General Hospital)<br />
Spain<br />
Dr Juan Hidalgo (Universidad<br />
Autonoma de Barcelona)<br />
Hungary<br />
Dr Zsolt Datki (University of Szeged)<br />
Israel<br />
Professor Irit Sagi (The Weizmann<br />
<strong>Institute</strong> of Science, Rehovot, Israel)<br />
Dr Inna Solomonov (The Weizmann<br />
<strong>Institute</strong> of Science, Rehovot, Israel)<br />
List of Scientific Visitors<br />
Professor Julie Anderson<br />
(Buck <strong>Institute</strong>, California, USA)<br />
Dr Scott Laffoon<br />
(Montana State University,<br />
Bozeman, MT, USA)<br />
Assistant Professor Math Cuajungco<br />
(California State University,<br />
Fullerton, USA)<br />
Professor Gordon Lithgow<br />
(Buck <strong>Institute</strong>, California, USA)<br />
Clinical <strong>Research</strong> Group<br />
Head<br />
Dr Kathryn Ellis BSc (Hons), PhD<br />
Clinical and Neuropsychology<br />
researchers<br />
Adrian Kamer BSc (Hons),<br />
Candidate DPsych (ClinNeuropsych)<br />
Carolina Restrepo (Psych)<br />
Fiona Lamb BASc(Psych)(Hons),<br />
DPsych(ClinNeuro)<br />
Harriet Downing BA, PGrad Dip Psych,<br />
Candidate DPsych (ClinNeuropsych)<br />
Jo Robertson BA(Psych)(Hons)<br />
Karra Harrington BA<br />
Rachel Buckley BSc(Psych)(Hons)<br />
Stacey Walker<br />
Molecular Biology <strong>Research</strong>ers<br />
Brett Trounson BSc (Hons) - AIBL Blood<br />
Processing Laboratory Manager<br />
Dr Christopher Fowler BSc (Hons) - PhD<br />
Kelly Pertile BSc (Hons) -<br />
<strong>Research</strong> Assistant<br />
Rebecca Rumble BBioSc (Hons) -<br />
<strong>Research</strong> Assistant<br />
Postdoctoral Fellows<br />
Dr Alan Rembach BSc (Hons),<br />
PhD - Postdoctoral <strong>Research</strong> Fellow<br />
Dr Noel Faux BSc (Hons), Grad Dip<br />
Comp Sci, PhD<br />
DIAN Study<br />
Alicia Rooney BSc, BNurs,<br />
GCHumanFact<br />
<strong>Research</strong> Nurses<br />
Fairlie Hinton RN<br />
Alison Boyd<br />
Susan Dickie RN<br />
Administration<br />
Yumiko Matsumoto<br />
Visiting Scientist<br />
Gobhathai Sittironnarit MD<br />
Senior AIBL Study Scientists<br />
and Collaborators<br />
Professor David Ames<br />
(National Ageing <strong>Research</strong> <strong>Institute</strong>)<br />
Professor Kaarin Anstey<br />
(Australian National University)<br />
Associate Professor Marc Budge<br />
(Australian National University)<br />
Professor Ashley Bush<br />
(<strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong>)<br />
Associate Professor David Darby<br />
(CogState)<br />
James Doecke (CSIRO Mathematical<br />
and Information Sciences)<br />
Dr Maree Farrow<br />
(Alzheimer’s Australia Victoria)<br />
Associate Professor Jonathan Foster<br />
(Edith Cowan University)<br />
Norm Good (CSIRO Mathematical and<br />
Information Sciences)<br />
Professor Richard Head (CSIRO)<br />
Professor Peter Hudson (CSIRO)<br />
Professor Nicola Lautenschlager<br />
(The University of Melbourne)<br />
Dr Qiao-Xin Li<br />
(The University of Melbourne)<br />
91
92<br />
Personnel<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Dr Lance Macaulay (CSIRO)<br />
Simon McBride (The Australian e-<strong>Health</strong><br />
<strong>Research</strong> Centre)<br />
Professor Paul Maruff<br />
(<strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong>)<br />
Professor Ralph Martins<br />
(Edith Cowan University)<br />
Professor Colin Masters<br />
(<strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong>)<br />
Andrew Milner (Neurosciences Victoria)<br />
Lynette Moore<br />
(Alzheimer’s Australia Victoria)<br />
Dr Timothy O’Meara (CSIRO)<br />
Glenn Rees (Alzheimer’s Australia)<br />
Professor Chris Rowe (Austin <strong>Health</strong>)<br />
Olivier Salvado (CSIRO e-<strong>Health</strong>)<br />
Associate Professor Greg Savage<br />
(MACCS)<br />
Jack Sach<br />
(Alzheimer’s Australia Victoria)<br />
Dr Wichat Srikusalanukul<br />
(Australian National University)<br />
Dr Cassandra Szoeke<br />
(CSIRO Preventative <strong>Health</strong>)<br />
Kevin Taddei (Edith Cowan University)<br />
Associate Professor Victor Villemagne<br />
(Austin <strong>Health</strong>)<br />
Associate Professor Michael Woodward<br />
(Austin <strong>Health</strong>)<br />
Associate Professor Olga Yatsrubetskaya<br />
(The University of Melbourne)<br />
Clinical Discovery Unit<br />
Head of Program<br />
Professor Michael Berk MBBCh, MMed,<br />
FF(Psych)SA, FRANZCP, PhD<br />
Co-Investigators<br />
Professor Ashley Bush MB BS, DPM, PhD,<br />
FRANZCP<br />
Associate Professor Maarten van den<br />
Buuse PhD<br />
Professor Gin Malhi BSc Pharmacl (Hons),<br />
MBChB, MRC Psych, FRANZCP, MD<br />
Professor Flavio Kapczinki MD, PhD<br />
Professor Brian Dean MSc, PhD<br />
Postdoctoral Scientist<br />
Dr Olivia Dean PhD<br />
Trial Clinicians<br />
Dr Sue Jeavons BA Psych (Hons),<br />
MPhil (Clinical Psychology), PhD<br />
Karen Hewitt<br />
Michelle Tanious BmedSci (Hons),<br />
GradDipPsych<br />
Postgraduate Students<br />
Kristi-Ann Villagonzalo BSc (Hons)<br />
Collaborators and Visiting Fellows<br />
Dr Tina Andreazza PharmD, PhD<br />
Dr Clarissa Gama MD, PhD<br />
Dr Pedro Magalhaes PhD<br />
Dr Marc Udina MD<br />
Dr Yimming Wang PhD<br />
Victorian Brain Bank Network<br />
Head, Tissue Bank<br />
Professor Catriona McLean BSc, MBBS,<br />
FRCPA, MD<br />
Consultants<br />
Professor Brian Dean HND ApplBiol,<br />
MSc, PhD, Fl Biol<br />
Professor Colin Masters BMedSc (Hons),<br />
MBBS, MD, HonDLitt WAust, FRCPath,<br />
FRCPA, FAA, FTSE<br />
Associate Professor Suresh Sundram<br />
MBBS, MMed, PhD, FRANZCP<br />
Coordinator<br />
Fairlie Hinton<br />
<strong>Research</strong> Assistants<br />
Geoff Pavey BSc (Hons)<br />
Leanne Frazer BSc (Hons)<br />
Consultant Histologist<br />
Dr Ian Birchall BAppSc, MSc, PhD<br />
Collaborators<br />
Transplant and Family Liaison Coordinators<br />
(Donor Tissue Bank of Victoria)<br />
Pathologists, Medical Liaison Officers<br />
and Mortuary Technicians (Victorian<br />
<strong>Institute</strong> of Forensic Medicine)<br />
Psychotropic Drug Advisory Service<br />
Head<br />
Professor Nicholas Keks MBBS, MPM,<br />
PhD, FRANZCP<br />
Staff<br />
Christine Culhane BPharm, Grad Dip<br />
Hosp Pharm<br />
The Dax Centre<br />
Director<br />
Dr Eugen Koh BSc (Hons), MBBS, MPM,<br />
FRACGP, FRANZCP<br />
Senior Lecturer in Arts & Psychiatry<br />
(The University of Melbourne)
Personnel<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Collection Manager<br />
Anthony Fitzpatrick BA (Hons), Postgrad<br />
Certificate(Art Conservation Studies),<br />
MA (Art Curatorship)<br />
Exhibition Manager<br />
Loretta Shepherd BA (Psychology<br />
& Economics), Grad Dip<br />
Communications, Grad Dip Art History,<br />
MA (Art Curatorship)<br />
Education Manager<br />
Penelope Lee RN, RPN, BA (Hons), FPV<br />
Certificate (Acting until April 2010)<br />
Anita Kopiec(Until Aug 2010)<br />
Emma Last Grad Dip Family Therapy,<br />
BA Social Work, Bach of Arts (From<br />
Aug 2010)<br />
Psychoanalyst in Residence<br />
Associate Professor Frances Salo<br />
Communication and Administration<br />
Manager<br />
Kirsten Kachab BEd (Primary),<br />
Grad Cert (Counseling)<br />
Project Managers<br />
Margaret Nixon DipEdDipArts<br />
PiaBrous (Honorary) MBBS, BMedSc,<br />
MPM, FRANZCP, Certif Child Psychiatry<br />
Public Programs, Partnerships &<br />
Professional Development Manager<br />
Penelope Lee RN, RPN, BA (Hons), FPV<br />
Certificate<br />
Curatorial Staff<br />
Juliette Hanson BA (Art History &<br />
Philosophy), MA(Art Curatorship)<br />
Alison Langley BSc, BA (Fine Art)<br />
(casual)<br />
Zoe Evershed BA (Hons Visual) (casual)<br />
Charlotte Christie BCA, DML, MA<br />
(Art Curatorsip)<br />
Dr Hassanah Briedis BA, MA<br />
(Creative Arts Therapy), PhD (Arts)<br />
Transition Manager<br />
Dr Kim Selling BA (Hons), Phd<br />
(Doctor of Philosophy), MA<br />
(Sustainable Heritage Development<br />
& Management) (Until Sep 2010)<br />
Communications Officer<br />
Cara Schultz BA (Hons)<br />
(From November 2010)<br />
Schools Coordinator<br />
Glenda UrquartBEd , Grad Dip<br />
Psychology<br />
Megan LeeBBNsc, DipEd<br />
Education Officers<br />
Penelope Lee RN, RPN, BA (Hons),<br />
FPV Certificate<br />
Deb Zipper BA Occupational Therapy<br />
Cassie Redlich (Until July 2010)<br />
Rachel Lysaght (Until Aug 2010)<br />
Personal Assistant to the Director<br />
Jo Whatley BA, Postgrad Dip (Art<br />
Curatorial Studies) (Until March 2009)<br />
Amy Middleton BA (Hons), MA (Arts<br />
Management) (from March 2010)<br />
Julia Robinson Grad Dip Marketing<br />
(From November 2010)<br />
Executive Assistant and Development Officer<br />
Bridget MacLeod BFA MA (Art<br />
Curatorship) (from June 2009)<br />
Administration Officer<br />
Susan Murphy BEd<br />
Publication & Grants Officer<br />
Jessica Raschke PhD, BA<br />
Fundraising Consultant<br />
Stephanie Joseph<br />
Conservation Students<br />
Louise Allen<br />
Johanna Ellersdorfer<br />
Tegan Broderick<br />
Jane Manallack<br />
Curatorial Scholarship Students currently<br />
enrolled in MA (Art Curatorship),<br />
The University of Melbourne<br />
Nikki Anderson<br />
Georgie Adams<br />
Advisory Committee<br />
Chair: Associate Professor Elizabeth<br />
Dax, AM<br />
Dr Sandra Hacker, AO, Board Chair,<br />
<strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong><br />
Professor Sid Bloch, Professor of<br />
Psychiatry,St Vincent’s Hospital<br />
93
94<br />
Personnel<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Ms Suzanne Davies, Director and Chief<br />
Curator, RMIT Gallery<br />
Ms Caroline Hogg, Former Minister<br />
for <strong>Health</strong><br />
Mr Robert Knowles, Former Minister<br />
for <strong>Health</strong><br />
MrJohn Lesser, Legal Member<br />
Executive Director’s Office<br />
Executive Director<br />
Professor Colin Masters BMedSc (Hons),<br />
MBBS, MD, HonDLitt WAust, FRCPath,<br />
FRCPA, FAA, FTSE<br />
Emily Cuningham BBiomedSci (Hons<br />
Sci) - Personal <strong>Research</strong> Assistant<br />
Brenda Huckstepp - Secretary<br />
Administrative Services<br />
Chief Operating Officer and Company<br />
Secretary<br />
Lisa Keam GradDip IP Law, BSc<br />
Commercialisation and Business<br />
Development<br />
Michael Vovos - (from 9 September 2010)<br />
Development and Communications<br />
Ross Johnstone MFIA - Development<br />
and Communications Manager<br />
Nichole Alfreds BA, MFIA - Fundraising<br />
Communications Coordinator<br />
Dianne Clark FFIA - Bequests<br />
(from April 2010)<br />
Jo-Anne Morgan - Events<br />
Babita Narayan - Development Assistant<br />
Finance and Administration<br />
Nick Catton LLB, BMS - Accountant<br />
Brian Fleming BBus(Acc) - Assistant<br />
Accountant<br />
Marinos Tsikkos - Receptionist<br />
Alistair Kittson - Administration Assistant<br />
Human Resources<br />
Rachel Mostacci - HR and<br />
Administrative Officer<br />
Information Technology<br />
Rik Casama BSc - IT Manager<br />
Gena Shoykhet BIS - IT Officer<br />
Laboratory Services<br />
Anna Sellens BSc (Hons) -<br />
Laboratory Facilities Manager<br />
Jason Verde Dip Animal Tech -<br />
Animal Facility Manager<br />
Lisa Madigan Dip Animal Tech -<br />
Animal Facility Technician<br />
(until 5 March 2010)<br />
Malcolm Marshall - Animal Facility<br />
Assistant (until 7 July 2010)<br />
Melissa Cameron - Technical Assistant<br />
(from 15 March 2010)<br />
Elissa Wells Dip Animal Tech - Technical<br />
Assistant (from 8 November 2010)<br />
Elsa Tsui - Laboratory Assistant<br />
Michael Kent - Property &<br />
Maintenance Manager<br />
Don Kuruppu, NDT, CGI (London) -<br />
Laboratory Assistant<br />
Governors<br />
Mr Charles Allen AO<br />
Dr Di Bresciani<br />
Mr Richard Buxton<br />
Mr Peter Clemenger AM<br />
Professor David Copolov OAM<br />
Mr Ian Farrington<br />
Professor George Fink<br />
Mr Roger Flynn<br />
Mr Doug George AM<br />
Dr David Greatorex AO<br />
Ms Caroline Hogg<br />
Mr John Kearney AM QC<br />
Dr Ben Lochtenberg<br />
Mr Geoff Marshall<br />
Mr George McMaster<br />
Dame Elisabeth Murdoch AC DBE<br />
Emeritus Professor Sir Gustav Nossal<br />
Mr Ross Oakley<br />
Mr Andrew Wardlaw<br />
Mrs Liz Wardlaw<br />
Ms Meredith Woods
Donations<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Thank you<br />
We are grateful to the many<br />
individuals, businesses and<br />
philanthropic trusts and foundations<br />
who support our work by donating,<br />
participating in events, purchasing<br />
our Christmas cards or sharing their<br />
expertise, all of whom are listed in<br />
these pages.<br />
In-kind Supporters<br />
Audi Penfold<br />
Barbecues Plus<br />
Block Arcade<br />
Briner Signs<br />
CAMCARE Charity Christmas Card Shop<br />
Mr Alf Caruana<br />
Coopers<br />
Department of Human Services, <strong>Mental</strong><br />
<strong>Health</strong> Branch<br />
Dulux<br />
Gerrand & Associates<br />
Melbourne Theatre Company<br />
Middletons Lawyers<br />
Monash University<br />
Mr Ross Oakley<br />
Mutual Ltd<br />
One in Five Association<br />
Royal Yacht Club of Victoria<br />
Sanpellegrino<br />
The Age<br />
The Egg<br />
The University of Melbourne<br />
Whybin / TWBA<br />
Wardlaw Family<br />
Woods Family<br />
Yering Station<br />
$50,000 – 199,999<br />
Mrs Anne Kantor<br />
Australian Rotary <strong>Health</strong><br />
Estate of Eva Orloff<br />
Joan & Peter Clemenger Trust<br />
Mr J F Kearney AM QC &<br />
Mrs M A Kearney<br />
Mr & Mrs Douglas & Anne Rathbone<br />
The William Buckland Foundation<br />
$10,000 – 49,999<br />
Mr & Mrs John & Lorraine Bates<br />
Geoff & Helen Handbury Foundation<br />
Mr Pieter Huveneers<br />
Mrs Pam Knott<br />
Mrs Norma Leslie<br />
Reece Australia Ltd<br />
The Bailey Charitable Trust<br />
The Isabel & John Gilbertson<br />
Charitable Trust<br />
The Mason Foundation<br />
$2000-9,999<br />
Mrs R Andre & Miss M O’Sullevan<br />
Australian Rotary <strong>Health</strong><br />
Ms Helen Baldwin<br />
Berwick Opportunity Shop Incorporated<br />
BP Australia<br />
Mr Ross Bryant<br />
Coventry Group Limited<br />
Cross Docks Australia<br />
Disha<br />
Dixson Trust Pty Ltd<br />
Djerriwarrh <strong>Health</strong> Services<br />
Mr Andrew Erikson<br />
Esso (BHP Billiton)<br />
Mrs Neilma Gantner<br />
Mr & Mrs Dean & Ilana Harris<br />
Hart Charities Pty Ltd<br />
<strong>Health</strong> Super<br />
Jianguo Pty Ltd<br />
Mr A P Kelly<br />
Mr John Leaver<br />
Mrs Diana M Lowe<br />
Melbourne <strong>Institute</strong> of Business and<br />
Technology<br />
NHP Electrical Engineering Products P/L<br />
Parks Victoria<br />
Mr Nigel H Peck AM & Mrs Patricia Peck<br />
Mr David G A Say<br />
Ms Pauline Speedy<br />
Mr Hugh R Taylor<br />
The Angior Family Foundation<br />
Warringal Financial Services Pty Ltd<br />
Dr Robin Wilson<br />
Wilson Security<br />
Mrs Meredith Woods<br />
Lady June Zeidler<br />
$200 – 1,999<br />
Mr Steve Abeckett<br />
Ms Stephanie Aeuckens<br />
Mr Cameron Afrasiabi<br />
Mr Douglas Agnew<br />
Mrs M C Ainsworth<br />
Mr & Mrs Michael Aitken<br />
Ms Nichole Alfreds<br />
Anglican Parish of Wagga Wagga<br />
Mr D M Aston<br />
Mr James Atkins<br />
Mr Robert Audsley<br />
Dr W J Bailey AO<br />
Mr Paul Bartlett<br />
Mr J G Bate OAM<br />
Dr Josephine Beatson<br />
Mr Dean Bedggood<br />
95
96<br />
Donations<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Belmore Park Pty Ltd Carroll Family Trust<br />
Mr Mark Bezemer<br />
BHP Billiton<br />
Dr Ian Birchall<br />
Mrs Annette Bird<br />
Mr Andrew Blaak<br />
Mr E Bladeni<br />
Mr G R Blair<br />
Professor Sidney Bloch &<br />
Mrs Felicity Bloch<br />
Dr John P Bomford<br />
Mr Joseph Bounader<br />
Ms Margaret Bounader<br />
Miss Sarah Bowden<br />
Mr John Bowen<br />
Professor Judith Brine<br />
Brookfield Mulitplex Construction Pty Ltd<br />
Mr Leo Browne<br />
Mrs Pearl Bruhn<br />
Dr & Mrs Mark & Ann Bryce<br />
Mrs M J Bugg<br />
Burn O’Donoghue Commercial<br />
Mrs Ellen M Burt<br />
Miss E M Butt<br />
Mr Jarrod Byham & Mrs Sally Emerson<br />
C R Kennedy & Company Pty Ltd<br />
Ms Rochelle Cairns<br />
Mr Allan Callender & Mr Tom Callender<br />
Mr Pat Callisto<br />
Camberwell Charity Christmas Card Shop<br />
Mrs June Cameron<br />
Mr John Carey<br />
Mr & Mrs Joe & Samar Chalin<br />
The Hon S P & Mrs J J Charles<br />
Ms Susan Chun<br />
Ms Di Clark<br />
Mr & Mrs Tim & Julie Clarke<br />
Mrs Florence Clarridge<br />
Mr & Mrs J L & E S Cleland<br />
Mr F J Colwell<br />
Confoil Pty Ltd<br />
Dr & Mrs Geoffrey & Joan Conron<br />
Mrs Heather Coombes<br />
Ms Kristine Cooney<br />
Professor David Copolov & Associate<br />
Professor Christine McDonald<br />
Mr Kevin J Cosgrave<br />
Mrs Anne Cowan<br />
Ms Helen Cowan<br />
Mr L Gordon Darling AC CMG<br />
Mr Ernest F Dawes OBE FTS<br />
de Malet & Assoc Pty Ltd<br />
Decor Corporation<br />
Dr & Mrs C M Deeley<br />
Mr A L Dickson<br />
Mr Jim Dingwall<br />
Mr & Mrs J & D Dixon<br />
Ms Billie Donaldson<br />
Ms Sue Donaldson<br />
Ms Felicity Druce<br />
Mr John Duncan<br />
Miss Yvette Dutt<br />
Eastbeth Services Pty Limited<br />
Eastwood Primary School<br />
Mrs F R Edens<br />
Mr Carl Elliott<br />
Mr Z Elton & Dr Diana Elton<br />
Mr David Farnsworth<br />
Mr Julian Feller<br />
Mr Brian Fleming<br />
Mr Roger B Flynn<br />
Mr Andrew Fraser<br />
Dr George Freed<br />
Ms Judith Freund<br />
Dr A K Fryday<br />
Mr G J Fulton<br />
Mr Drew Fyfe<br />
S Gaylard<br />
GCB Bookkeeping Pty Ltd<br />
Mrs Sylvia Gelman AM MBE<br />
Miss Belinda Gibson<br />
Mr R N Gotch<br />
Mrs L M Gourlay OAM<br />
Ms E M Graham<br />
Mrs Lesley Griffin<br />
Mrs J B Guerin<br />
Dr James Guest AM OBE & Mrs Guest<br />
Dr Sandra Hacker AO<br />
Mr Wayne Hall<br />
Ms Kate Hamilton<br />
Justice H R Hansen<br />
Mr Roy Hardcastle<br />
Miss Joan M Harman<br />
Mr Dan Harris<br />
Mr & Mrs Peter & Elaine Harris<br />
Mr Nick Hartigan<br />
Mrs Kathleen Hatch<br />
Mrs June Haughton<br />
Ms Fiona Healy<br />
Ms Elizabeth M Heinze<br />
Mr Eric Herding<br />
Mrs Carolyn J Hewson<br />
Mr Ian Hicks<br />
Mr Jack Hines<br />
Mrs Zara Hines<br />
Ms W E Hirst<br />
Mrs I Y Hoolihan<br />
Mr Peter Horstmann<br />
Ms Jannie Howard<br />
Ms Penny Hughes & Frank Lewis<br />
Mr Michael Hutchison<br />
In Vogue Blinds Pty Ltd<br />
Mr Rowan V Ingpen<br />
Interpath Services Pty Ltd
Donations<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Jalna Dairy Foods Pty Ltd<br />
Dr Brian D James<br />
Ms Louise James<br />
Professor Norman James<br />
Ms Therese James<br />
Dr Elcahnan H Januszewicz<br />
Ms Lisa Jeffery<br />
Mr David Joachim<br />
Mr Ross J Johnstone<br />
Karingal Bowling Club Inc<br />
Mr & Mrs D & M Kaufmann<br />
Ms Jane F Kelly<br />
Mr Howard Kemball<br />
Mrs Michelle Kenna<br />
Ms Anna Kerrison<br />
Mr John Kirkhope<br />
Mrs B M Kohane<br />
Dr Jerzy Krupinski<br />
Ms Margaret Ladanyl<br />
Mrs Eve Landman<br />
Mr John Landy AC CVO MBE<br />
Ms Sarah Lane<br />
Mr R F Lauwers<br />
Mr Rod Law<br />
Miss Kate Leddick<br />
Miss Kate Lemon<br />
Mr D W & Mrs W I Leslie<br />
Mr J B Leslie AC & Mrs A Leslie<br />
Mr John Lesser<br />
Mr Lewis Lester<br />
Ms Emily Lewis<br />
Miss Kay Lewisohn<br />
Mr Ambrose Linke<br />
Ms Pearl Lubansky<br />
Lubrimaxx Marketing Pty Ltd<br />
Ludden Group<br />
Mr Paul Ludekens<br />
Mrs J A Lunt<br />
Ms Rosemary B S Macindoe<br />
Mr & Ms R & M Maeder<br />
Mr Don Maloney<br />
Mr Andrew Mansour<br />
Ms Greta Matzat<br />
Mr Kent May<br />
Mr Justin McCarthy<br />
Mrs Vivien McCarthy<br />
Dr Ian W McCay<br />
Ms P T McColl<br />
Mrs Linda McConnell<br />
Miss Ursula McFadden<br />
Mr Bruce Mckenzie<br />
Miss Claire McKeown<br />
Ms Anna McLaren<br />
Dr & Mrs A P & M S McPhate<br />
McPherson’s Limited<br />
Mr & Mrs R A McVicker<br />
MECU Ltd<br />
Mrs Janice Medway<br />
Mr & Mrs Ron & Margot Meldrum<br />
Mr John Michaux<br />
Mr Brad Mogferd<br />
Mr K Moller<br />
Mr & Mrs Brian & Marilyn Moloney<br />
Mr W F Montague OAM<br />
Mr Stephen Moore<br />
Mr & Mrs G A & C R Morgan<br />
Mr Richard Moshinsky<br />
Dr Bruce Munro<br />
Mr Elie Nasri<br />
Mr John Nixon-Smith & Mrs June Nixon-Smith<br />
Ms H M Oakes<br />
Mrs Doreen O’Brien<br />
Mrs S Ohl<br />
Mr Gareth Old<br />
Mr Matthew Osbourne<br />
Mr James Paterson<br />
Mr Jeremy Paterson<br />
Mrs Tina Paterson<br />
Penfold Motors<br />
Ms Rhonda Peters<br />
Dr D M Pinkerton<br />
Mr R G Pitcher AM<br />
Mr Roland Pless<br />
Mrs Margaret Poh Kam Chan<br />
Mrs Jean Potter<br />
Mr Philip Potter<br />
Ms Fiona Powell<br />
Mr Ian Pratt<br />
Mr Greg Rafferty<br />
Mr J T Ralph AC<br />
Ralph Meats<br />
Mr Robert Reed<br />
Mrs Ann Reid<br />
Ms Catherine Reilly<br />
Mr Ralph Renard<br />
Mr Chris Richardson<br />
Ritchies Expense Company<br />
Mr D W Rogers<br />
Rotary Club of Central Melbourne<br />
Mr Peter Rowell<br />
Mrs Margaret Royston<br />
Ms Kirsten Ruddo<br />
Mr Matthew Ryan<br />
Mr & Mrs P & E Ryba<br />
Mr Ron Sacks-Davis<br />
Mr Quin Scalzo<br />
Mr Ian Seymour<br />
Dr Garry Sheehan<br />
The Hon Jim Short<br />
Mr & Mrs M & J Simmons<br />
Miss P Smart<br />
Mr A W Smith<br />
Mr Samuel Smorgon AO &<br />
Mrs Minnie Smorgon<br />
97
98<br />
Donations<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Mr Richard Solomons<br />
Solubility Pty Ltd<br />
Ms Fiona Somerville<br />
Mr & Mrs J & L Somerville<br />
Somerville Lions Club<br />
Mrs Lyn South<br />
Mrs Ana Spremic<br />
Mr & Mrs Phillip & Genny Steer<br />
Mr & Mrs A W Stephens<br />
Mr Russell Stewart<br />
Ms Caroline Storm<br />
Mrs Fay Strachan<br />
Mr & Mrs Anthony Sullivan<br />
Ms R E Swanson<br />
Mr James Syme<br />
Mr Rowan Tatchell<br />
Ms Brooke Taylor<br />
Mr Robin Taylor<br />
Mr & Mrs B & P Teague<br />
The Leo & Mina Fink Fund<br />
The William Angliss (Vic)Charitable Fund<br />
Thomson Playford Cutlers<br />
Dr Bruce Thorley<br />
Mr Robert C Thrower<br />
Mr & Mrs J G Thrum<br />
Mr Andrew Tinney<br />
Mrs Marjorie Todd<br />
Dr Diana Tolhurst<br />
Mr David Travers<br />
Dr Gad Trevaks AM<br />
Twentieth Super Place Nominees Pty Ltd<br />
Urbis Pty Ltd<br />
Ms Sally van Doorn<br />
Mr Brian Vernon<br />
Mr David Vernon<br />
Mr Stan Wallis AC & Mrs Judith Wallis<br />
Miss Leisl Walsh<br />
Mrs M Walsh<br />
Mr Ralph Ward-Ambler AM &<br />
Mrs Barbara Ward-Ambler<br />
Mr Tim Watkin<br />
Mr Philip Weickhardt<br />
Mrs Claudine West<br />
Ms Rachela H West<br />
Dr W Whitton<br />
Mr John V Wilkins<br />
Mr Paul A Willee QC<br />
Mrs Lyn Williams AM<br />
Mrs Margaret Wilson<br />
Mr J Wise<br />
Mr Peter C Wolfe<br />
Ms Nadia Woodhouse<br />
Mrs Sheila Wynne<br />
Mr & Mrs L & E Yoannidis<br />
$2 – 199<br />
Mrs Jane Aarons<br />
Mrs Jennifer Abraham<br />
Mrs Heather Abramson<br />
Mr W J Absalom<br />
Ms Sharon Aceret<br />
Mr & Mrs I D Ada<br />
Ms Peta Adams<br />
Mr W Adams OAM<br />
Mr Jaira Adlawan<br />
Mr Michael Agresta<br />
Mr Allan Aitken<br />
Ms Gabrielle Aitken<br />
Ms Kim Aitken<br />
Ms Zoe Aitken<br />
Mr Ebru Akerman<br />
Ms Zexi Allan<br />
Mrs Angela Allen<br />
Ms Cassy Allen<br />
Dr Glenison Alsop<br />
Mrs Alsop<br />
Mr & Mrs FM & H Altman<br />
Ms Fiona Alveyn<br />
Mrs Beverley Alway<br />
Ms Lisa Amad<br />
Ms Angela Anderson<br />
Ms Sally Anderson<br />
Mrs Elizabeth Andrews<br />
Mr Ingmar Apinis<br />
Miss Samantha Appleby<br />
Mrs A M Arbuckle<br />
Mr Andrew Arendsen<br />
J Armstrong<br />
Mrs V Armstrong OAM<br />
Mr Andre Arndt<br />
Miss E Arthur<br />
Mrs Lara M Atkins<br />
Mr Alexandra Auaguostakis<br />
Mr Daniel Auld<br />
Mr Antony Auliso<br />
Mr Matthew Backman<br />
Mr Andrew Badcoe<br />
Mrs Patricia Baddeley<br />
Dr Joseph Badr<br />
Mrs Beth Bailey<br />
Mr Hugh Bailey<br />
Mrs Julie Bailey<br />
Mr Ameet Bains<br />
Mr Peter Baird<br />
Mr & Ms B K & H Baker<br />
Mrs T Baker<br />
Mr Richard Baldwin<br />
Ms Karen Ball<br />
Mr Dale Bangco<br />
Mr Peter Banyasz<br />
Mr Doron Bard<br />
Mr Morris Bardas<br />
Mrs Mary Barker<br />
Ms Jennifer Barnes
Donations<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Mr Melvyn Barnett<br />
Mr Merv Barnett<br />
Ms Felicity Barr<br />
Miss Joanna Barrett<br />
Mrs Manola P Barrett<br />
Mr Peter Barrie<br />
Mrs Jane Barron<br />
Mr G Bartle<br />
Miss Layna Bartlett<br />
Mr & Mrs N & L Bartolo<br />
Dr Bridget Bassilios<br />
Mr David Bastian<br />
Mrs Carolyn Bastock<br />
Mr J L Bath<br />
Dr Sue Batista<br />
Mrs Laura Battistella<br />
Mr Richard Baum<br />
Ms Alison Bayne<br />
Ms M P Beard OAM<br />
Mrs Jean Beaumont<br />
Mrs Ann Beck<br />
Mrs Carla Beck<br />
Mr Chris Beckman<br />
Ms Anne Beilby<br />
Mrs Doreen Bell<br />
Mr Aaron Belton<br />
Mr Brucey Belton<br />
Mrs Diana F Benefield<br />
Miss B R Benjamin<br />
Mr David Benjamin<br />
Mr Dean Benjamin<br />
Mr David Bennett<br />
Mr Sol Benporath<br />
Mrs Barb Benson<br />
Mrs Tanya Bentata<br />
Mr Colin Berry<br />
Ms Hollie Bevans<br />
Mrs V Bicknell<br />
Mr Michael Bidey<br />
Mr & Mrs C & I Billinghurst<br />
Ms Margaret Birch<br />
Dr William Birch AM<br />
Dr Ruth Birrell<br />
Ms Franca Bisaz<br />
Mr & Mrs Robert & Patricia Bish<br />
Miss Mel Blackson<br />
Ms Robin Blair<br />
Mr & Mrs BL & MP Blannin<br />
Mr Emilio Blasetti<br />
Miss Melanie Blint<br />
Miss M Blundell<br />
Miss Aimee Board<br />
Ms Sonya Bohlen<br />
Mrs Sharon Boissonneault<br />
Miss Ciara Boland<br />
Miss Nancy Bonarrigo<br />
Miss Helen Bonello<br />
Mr Stephen Booth<br />
Mr Richard Borghesi<br />
Ms Christina Bos<br />
Ms Maria Bottos<br />
Ms Kim Bowers<br />
Miss Kim Boyle<br />
Mrs Emma Bradburn<br />
Miss Madeline Brady<br />
Mrs Mindy Brake<br />
Mr David Bramley<br />
Mr & Mrs A Brecknell<br />
Ms Amy Brennan<br />
Mr B M Brennan<br />
Mr Tim Brennan<br />
Mrs Geni Brewster<br />
Mr John Bride<br />
Mrs Anneliese Bridges<br />
Mrs Joanne Brimelow<br />
Mrs Marietta Brinkley<br />
Ms Sonia Brockington<br />
Mr Adam Broder<br />
Mr Daniel Brooke<br />
Mr Ian Brookman<br />
Ms Kerry Brougham<br />
Ms Beth Brown & Mr Tom Bruce AM<br />
Mr David Brown<br />
Ms Rebecca Brown<br />
Mrs Sally Brown<br />
Mrs Linda Bruce<br />
Ms Caroline Bruckner<br />
Ms Irene Buchanan<br />
Mr J A Buchanan<br />
Mr Aaron Buckley<br />
Mrs Carol Bueno<br />
Mr Rocco & Kristina Bueti<br />
Mr H Bufe<br />
Mrs Huong Bui<br />
Ms Huong Bui<br />
Mr A B Bunnett OAM<br />
Ms Sonya Bunting<br />
Ms Ann-Marie Burgar<br />
Ms Helen Burge<br />
Mr Michael Burke<br />
Ms Colleen Burnes<br />
Ms Fiona Burnes<br />
Miss Georgia Burns<br />
Mr Joel Burstyner<br />
Dr Carol A Burton<br />
Mr G & M Buschmann<br />
Mr William Bussau<br />
Miss R I Byers<br />
Mr & Mrs L & R Calabrese<br />
Mr James Callander<br />
Ms Sophie Callander<br />
Mr David Calleja<br />
Ms Michelle Calligaro<br />
Mr Jeremy Callman<br />
99
100<br />
Donations<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Mrs Judy Callman<br />
Mrs Fleur Calvert<br />
Mr Graeme Calway<br />
Ms Margie Cameron<br />
Mr & Mrs Neil & Pam Cameron<br />
Ms Trish Cameron<br />
Mrs B M Campbell<br />
Mr David Campbell<br />
Mr Simon Canny<br />
Mr Paul Canterbury<br />
Mr Adrian Cantwell<br />
Mr Rocco Capogrecco<br />
Ms Dawn Carey<br />
Mrs Zanon Carla<br />
Ms Annette Carlin<br />
Mr Pete Carnell<br />
Miss Una Carney<br />
Mr Jon Carr<br />
Mr Brian Carson<br />
Mr David Carswell<br />
Mrs Susan Carter<br />
Mr Lachlan Carty<br />
Mr Ricardo Casama<br />
Mr Paul Cassidy<br />
Mr Rob Cassr<br />
Mrs B K Cates<br />
Mrs Jocelyn Cato<br />
Mr Hugh Cattermole<br />
Mr Nick Catton<br />
Mrs Yolanda Catton<br />
Ms Tanya Cawthan<br />
Mrs Susie Cay<br />
Mr Neil Chadwick<br />
Mr Anthony E Chaloner<br />
Mr William Chan<br />
Ms Jill Chapman<br />
Mrs Jo Charalamt<br />
Mrs P A Chaston<br />
Ms May Chen<br />
Mr Tony Chen<br />
Dr I G Chenoweth<br />
Mr Jack Chester<br />
Ms Gabriella Chirumbolo<br />
Mr Peter Chisnall<br />
Mrs Jennifer Chrystie<br />
Mr Kenneth Chung<br />
Mr Frank Clark<br />
Mrs H Clark<br />
Ms Penelope Clark<br />
Mr Brian Clarke<br />
Mrs P J Clarke<br />
Ms Heather Clay<br />
Clayton Bowls Club Inc<br />
Mrs Julie Cleary<br />
Mr Peter Cleaver<br />
Mrs Joan Cleeve<br />
Ms Lucy Cleeve<br />
Mr John Xavier Clifton<br />
Miss Kim Clipstone<br />
Ms Heidi Cmager<br />
Mr F J Coates<br />
Mr L E Coburn<br />
Mr Lance Coburn<br />
Mrs Leanne Coburn<br />
Mr Geoff L Code<br />
Mrs Michelle Cody<br />
Ms S M Cohen<br />
Mrs E M Coldwell<br />
Ms Helen Colla<br />
Mr & Mrs A Collins<br />
Ms Benita Collins<br />
Ms Fiona Collins<br />
Mr Haley Collins<br />
Mrs Julie Collins<br />
Miss Amy Colquhoun<br />
Mr Craig Combes<br />
Mrs Nadia Conn<br />
Mr Francis Constantinidis<br />
Mr V A Cooke<br />
Mr & Mrs BB & SH Cooling<br />
Miss Caroline Cooper<br />
Mrs Margaret Cooper<br />
Ms Richard Coorey<br />
Miss Melanie Copelin<br />
Mr Raoul Copolov<br />
Ms Noelene Copper<br />
Mrs Mareeta Corcoran<br />
Ms Irene Corr<br />
Mr Peter Corrigan<br />
Mrs Kate Coryndon<br />
Mr Terry Cosgriff<br />
Mrs N Costello<br />
Ms Norma Cotterell<br />
Ms Sarah Cotton<br />
Mrs Andree Coutts<br />
Mr Joshua Cowan<br />
Ms Deryn Cox<br />
Ms Katrina Cox<br />
Mr Andrew Cramer<br />
Mrs Kylie Crawford<br />
Mrs Pamela Crosthwaite<br />
Mr Scott Crough<br />
Mrs Deborah Crow<br />
Mr Simon Crowther<br />
Mr & Mrs J & C Crutchfield<br />
Ms Christine Culhane<br />
Mr Peter Cummiskey<br />
Miss Sally Cunningham<br />
Ms Hazel Currie<br />
Ms Sue Currie<br />
Mr Kieran Curtain<br />
Mrs Ella Czelen<br />
Miss Rebecca Dabbs<br />
Ms Angela Daffey
Donations<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Mr & Mrs R Dafter<br />
Ms Pam Dalrymple<br />
Mr Damian Dalton<br />
Ms Kate Dalton<br />
Mrs Julie Daly<br />
Mr Phillp Daly<br />
Mrs Marissa Damianidis<br />
Mr Anthony Daniel<br />
Ms Claire Daniel<br />
Ms Michelle Daniel<br />
Miss Oliva Darian<br />
Mr A D’Astoli<br />
Mr Adam Davidson<br />
Mrs Irene E Davidson<br />
Miss Kerry Davidson<br />
Ms Megan Davidson<br />
Mr Craig Davis<br />
Ms Lucy Davis<br />
Miss Debbie Davut<br />
Ms Anne Dawson<br />
Mrs R De Fegely OAM<br />
Mr Domenic De Marco<br />
Ms Kristin Dean<br />
Ms Maria DeBartolo<br />
Debstudio Interior Design<br />
Mr Abaran Deep<br />
Mrs S Deeves<br />
Miss Danielle Delaney<br />
Ms Kristina Dellosa<br />
Mr Steve DeLuca<br />
Dr Bill Denholm<br />
Mrs Jacqui Dennis<br />
Mr Richard Dent<br />
Ms Anna Derlin<br />
Ms Catherine Deszcz<br />
Mrs P J Devlin<br />
Mrs Gillian Dickson<br />
Mrs I V Dickson<br />
Ms Paula Dimakos<br />
Mr Paul Dinnage<br />
Mr Naush Dinshaw<br />
Mr Shane Doherty<br />
Mrs June Donald<br />
Ms Wenda Donaldson<br />
Miss Jane Donohoe<br />
Mrs Louise Doquile<br />
Ms Andrea Dore<br />
Ms Hannah Downie<br />
Mrs Rosemary Drenen<br />
Mr Marty Drill<br />
Miss Rebecca Driver<br />
Miss Linda Drvodelic<br />
Ms Janet Duff<br />
Ms Yasmin Dugan<br />
Mrs Clare Duggan<br />
Miss Rachael Duggan<br />
Mr D Dugger<br />
Mr Paul Duncan<br />
Mr Daniel Dungan<br />
Mrs Penny Dunn<br />
Mr Richard Dwyer<br />
Mrs Alexandra Dyball<br />
Ms Sharlene Eade<br />
Mrs Val Earl<br />
Mrs Rebecca East<br />
Mr & Mrs D & I J Eddleston<br />
Ms Annette Edwards<br />
Ms Mary A Edwards<br />
Professor Meredith A Edwards<br />
Mr Scot Edwards<br />
Ms Vanessa Edwards<br />
Mrs Barbara Elliott<br />
Ms Jessica Ellis<br />
Mr Earl Elpers<br />
Miss Nicola Elsom<br />
Mr Ben English<br />
Mrs Ottelina Erceg<br />
Mr & Mrs G Ermer<br />
Mr Bruce Etherton<br />
Miss Cassandra Eyres<br />
Mrs P A Fagg<br />
Ms P K Falcinella<br />
Mr Jim Falzon<br />
Ms Jane Fannon<br />
Mr David Farnsworth<br />
Ms Lynne Faulkner<br />
Mr Morgan Fayle<br />
Ms Jane Fenton<br />
Ms Ann Fernando<br />
Ms Fiona Ferrington<br />
Miss Caroline Ferris<br />
Ms Karen Field<br />
Mr Malcolm Fielden<br />
Mr Duncan Fikkers<br />
Mrs Elizabeth Fikkers<br />
Ms Gulay Filiz<br />
Mr Stephen Fisher<br />
Fit 4 Living<br />
Ms Barbara Flegg<br />
Mr & Mrs FE & KJ Fletcher<br />
Mr Peter Fletcher<br />
Mr Perks Flick<br />
Dr Eleanor Flynn<br />
Mr Chris Fogarty<br />
Ms Madison Foley<br />
Mrs Sue Foran<br />
Mr Clark Forbes<br />
Mrs & Mr Barb & Frank Ford<br />
Mr George Fordyce<br />
Warwick and Sue Forge<br />
Miss Erin Forrest<br />
Mr E C Foster OAM<br />
Mr George Fotakis<br />
Mr Andrew Fox<br />
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102<br />
Donations<br />
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Mrs Lyn Francis<br />
Mr Mircea Frandas<br />
Mr Reginald Freeman<br />
Ms Caroline Freemantle<br />
Ms Vera Freidin<br />
Mrs Vera Friedrich<br />
Ms Tracey Frigo<br />
Mr Fred Frohlich<br />
Mrs Beverley Fuller<br />
Mr Andrew Fulton<br />
Mr Ben Fulton<br />
Mr Stewart Fulton<br />
Mrs J A Gabb<br />
Mrs Susanne E Gabor<br />
Mr Andrew Gador-Whyte<br />
Ms Angela Gahan<br />
Mr Lambis Galanopoulos<br />
Mr Richard Galassi<br />
Miss Sarina Gale<br />
Mr Nikola Galinac<br />
Ms Edwina Gallagher<br />
Mr Scott Gallagher<br />
Mr & Mrs B & R L Gallaway<br />
Mr Neil Gardiner<br />
Miss Sheryl Gardner<br />
Mrs Paula Garnett<br />
Garry & Warren Smith Pty Ltd<br />
The Garry Martin & Associates Pty Ltd<br />
Mr Matt Gazzard<br />
Miss Stephanie Gebert<br />
Mr R Gehrig<br />
Ms Sarah Gelder<br />
Ms Amy George<br />
Mr Justin George<br />
Mr Michael George<br />
Ms Rosemary George<br />
Ms Judith Geraghty<br />
Mr Stuart Getley<br />
Ms V Giannarelli<br />
Ms Grace Giannini<br />
Miss Luisa Giannone<br />
Mr & Mrs D S & V I Gibb<br />
Mrs M J Gibson<br />
Mr Robert Gilbert<br />
Mr Steve Gilbert<br />
Ms Anne Gill<br />
Ms Alison Gilmore<br />
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Mr Thomas Gin<br />
Mr David Girolamo<br />
Mr Paul Gladwell<br />
Mr Apoorve Goel<br />
Mr Chong Ming Goh<br />
Mr Raph Goldenberg<br />
Mr John Goldlust<br />
Mr Dennis Goldner<br />
Mrs Tracy Gomall<br />
Ms Isabel Gonzalez<br />
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Mr Brian Goodwin<br />
Ms Julie Gordon<br />
Mr Peter Gordon<br />
Ms U Gordon<br />
Mrs Doreen Gordon-Kirkby<br />
Mrs Sue Gorman<br />
Ms Irene Gorr<br />
Mrs Erika Gough<br />
Ms Alaina Gougoulis<br />
Mrs Gaylene Gould<br />
Ms Anna Gouttmann<br />
Mr & Ms Dave & Kate Gowans<br />
Ms Doris Graham<br />
Mrs Carmen Granger<br />
Ms Patricia Grant<br />
Mrs M L Gray<br />
Mr Stuart Gray<br />
Mr Charles Grech<br />
Miss Barb Green<br />
Dr Todd Green<br />
Miss Rachel Greene<br />
Mrs Joyce Greenwood AM<br />
Mr Martin Griffith<br />
Mr Jordon Griffiths<br />
Mr Rob Grinter<br />
Mr Des Grogan<br />
Ms Loris L Grote<br />
Mr Guang Guan<br />
Mrs Anne Gugger<br />
Mr Christina Guglielmi<br />
Mrs H Gulson<br />
Mr & Ms M Weir H Densen<br />
H W I Electrical Ltd<br />
Mrs Edna Hackleton<br />
Mrs Andrea Haddad<br />
Mrs Jean Hadges<br />
Haines Muir Hill<br />
Mrs Alice Halasz<br />
Dr L A Hallett<br />
Mrs Shirley Hallows<br />
Mr Craig Hamilton<br />
Ms Eileen M Hamilton<br />
Ms Joan Hamilton<br />
Ms Olive M Hamilton<br />
Miss Kate Hancock<br />
Mrs Sally Hanley<br />
Mr Jake Hanneman<br />
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Mr Rick Harcourt<br />
Ms Angel Harden<br />
Miss V E Harding<br />
Mrs Julia Hare<br />
Mr & Mrs G B Hargreaves<br />
Ms Merrie Harkness<br />
Mrs E Harman
Donations<br />
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Miss Kate Harper<br />
Ms Alissa Harris<br />
Dr Karen Harris<br />
Mrs Lynette Harris<br />
Ms Ruth Harris<br />
Mrs Elizabeth Harrison<br />
Mr Stephen Harrison<br />
Miss Maura Harty<br />
Mr Simon Harvey<br />
Miss Helen Havryliv<br />
Ms Rosemary Hawkins<br />
Mrs Margaret A Hawksworth<br />
Mr Marty Hayes<br />
Mrs Alex Hayward<br />
Mr Freya Headlam<br />
<strong>Health</strong> Explanations Pty Ltd<br />
Mr Paul Healy<br />
Mrs Jane Hearn<br />
Ms Kerry Hecht<br />
Mrs Rosemary Heide<br />
Ms Desiree Hemberger<br />
Mr Ian Henderson<br />
Ms Janette Henderson<br />
Mr Tony Hennessy<br />
Mrs Edna A Herbert<br />
Ms Elizabeth Herd<br />
Mr Mark Herding<br />
Mrs Nancy Herding<br />
Mr Werner Herding<br />
Mr Michael Hermann<br />
Mr Erik Hetrick<br />
Mr Paul Thomas Hicks<br />
Mrs Jill Higginbotham<br />
Mr Vincent Higgins<br />
Mrs Margaret Higgs<br />
Mr Kim Hildebrandt<br />
Miss Lyndall Hillbrich<br />
Ms Margaret Hilton<br />
Ms Maureen Hilton<br />
Mr Mark Hindmarsh<br />
Mr Steven Hines<br />
Ms Fairlie Hinton<br />
Ms Pamela Hitchcock<br />
Mrs Deborah Hitchen<br />
Mrs Jean Hofmaier<br />
Ms Kate Holden<br />
Ms Marnie Holden<br />
Ms Jane F Holland<br />
Lady Suzanne Holland<br />
Mrs H Holman<br />
Mrs B Holmes<br />
Mrs Anna Holmstrom<br />
Ms Nanette Home<br />
Mrs J Homewood<br />
Mr Auostasio Hondros<br />
Ms Meni Hondros<br />
Mrs Monica Hopgood<br />
Mrs & Mr Chris & Alan Hopkins<br />
Mr John Hopper<br />
Mr Ted Hormer<br />
Miss Katie Horrell<br />
Mr R K Horsburgh AM<br />
Mr & Mrs W J Hosking<br />
Ms Nadine House<br />
Mr Scott Howard<br />
Ms Corinne Howell<br />
Miss Ceara Howley<br />
Mr Michael Hoyle<br />
Ms Brenda Huckstepp<br />
H J Hughes<br />
Mr L Hughes<br />
Miss L Hughes<br />
Mr Mark Hughes<br />
Mr Christopher Hunt<br />
Ms Mandy Hunt<br />
Mr Eric Hunter<br />
Mrs Anna Huntley<br />
Dr Agim Hymer<br />
Mrs Lisa Hynes<br />
Ms Shelley Hynes<br />
Mr & Mrs N Iddles<br />
Ms Joanne IIsley<br />
Mrs Suzie Jackobovits<br />
Miss Bethany Jackson<br />
Mr G A Jackson<br />
Mrs H E Jackson<br />
Mrs K Jackson<br />
Mr & Mrs K A & N J Jackson<br />
Ms Emma Jacques<br />
Ms Francesca James<br />
Ms Marian James<br />
Mr Peter Jamieson<br />
Miss Sophie Jamieson<br />
Mrs Ursula Jansen<br />
Ms Dianne Jenkins<br />
Mr Tony Jennett<br />
Mrs Olga Jensen<br />
Jeshimon House<br />
Mr John Jessup<br />
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Mr Tim Johansen<br />
Mr Myles Johansson<br />
Mr & Mrs Anna & Rhys Johnson<br />
Dr Mark Johnson<br />
Ms Trudi Johnson<br />
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Ms Eunice Jolliffe<br />
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Mr Matthew Jones<br />
Mr Peter Jones<br />
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Ms Brenda Jones_Evans<br />
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Mrs Cathryn Jowett<br />
Miss Ashlee Joyce<br />
Mrs Rachel Kalman OAM<br />
Mr Paul Kam<br />
Mr Andrew Kaplan<br />
Mr Adem Karafili<br />
Ms Linda Karafili<br />
Mrs & Mr Rosemary & Reg Karafili<br />
Ms Valentina Karafili<br />
Mr Andrew Karavias<br />
Mr Phil Karlhuber & Ms Jo- Anne Morgan<br />
Mr Alex Katsaros<br />
Mr E & E Katz<br />
Ms Margaret Kaye<br />
Miss Cathy Kayess<br />
Mrs Peg Keast<br />
Mr Francis C Keen<br />
Mr Samuel Keenan<br />
Mr Tony Kellar<br />
Ms Jennifer Kelso<br />
Ms & Mr Mary Kennedy-Jones & Paul Day<br />
Miss Sarah Kenner<br />
Ms Irene Kenny<br />
Mrs Jillian Kenny<br />
Mr Randall Kent<br />
Mr & Mrs Bryan & June Keon-Cohen<br />
Ms Olivia Kerr<br />
Mrs Baiba Kerrison<br />
Ms Sharon Keys<br />
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Ms Charlotte King<br />
Mr G E King<br />
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Mr Warrick King<br />
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Mr A J Kirkham AM<br />
Mr M C Kirkland<br />
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Mrs Marie Knight<br />
M E Knights<br />
Ms Jan Knox<br />
Mrs Maralyn Kobert<br />
Ms Laura Koh<br />
Mr & Mrs Bill & Dianne Koller<br />
Ms Samantha Korman<br />
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Mr & Mrs H & B Kosky<br />
Ms Eleftheria Kotsopoulos<br />
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Mr G Kuran<br />
Mr Don Kuruppu<br />
Ms Magenta Kuzbicki<br />
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Mr R Lanini<br />
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Mr Rod Lush
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Mrs M Lynch<br />
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Mrs Jacqui Malcolm<br />
Mr Kimberley Malcolm<br />
Mr Paul Malcolm<br />
Miss Alexandra Malfroy<br />
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Mrs M D March<br />
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Mr S Marks OAM<br />
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Mrs Dorothy Martin<br />
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Ms Diane Mason<br />
Ms Julia Mason<br />
Mr Chris Masterman<br />
Professor Colin L. Masters MD<br />
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Ms Maria May<br />
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Mr Cameron McAllister<br />
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Ms Melissa McCartin<br />
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Mr John McCormack<br />
Ms Jessica McCreadie<br />
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Mr Paul McDonald<br />
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Mr Andrew Mcevoy<br />
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McFadden Property Pty Ltd<br />
Ms Emma McGoldrick<br />
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Ms Laura McKenzie<br />
Miss Lyndal Mckenzie<br />
Ms Margaret McKenzie<br />
Mr Toby Mckinnon<br />
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Mrs P A McLean<br />
Mr W G McLean<br />
Mr Rodney McLeish<br />
Miss Tania McLeish<br />
Ms Kathy McLeod<br />
Mrs Catherine Mclntyre<br />
Father Daniel McMahon<br />
Dr Ruth McMahon<br />
Ms Suzanne McManus<br />
Mrs Theresa McManus<br />
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Mr John Milton<br />
Mir Bros Group of Companies<br />
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Mr Christopher Morgan<br />
Miss J Morgan<br />
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Mr Chris Morrey<br />
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Ms Danielle Moss<br />
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Mr N Moulden<br />
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Mulwala Football Club<br />
Des Munday & Son<br />
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Irvine Newton<br />
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Mr Dominic O’Brien<br />
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Ms Rosemary O’Connell<br />
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Ms Anne O’Donovan<br />
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Mr Muhair Parkes<br />
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Mr Des Patterson<br />
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Perfect Vision Systems<br />
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R & T (Australia) Pty Ltd<br />
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Mr Tim Rasmusse<br />
Ms Michelle Rasmussen<br />
Mr Philip Ratcliff<br />
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Mrs M Riccio<br />
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Mr Iain Roberts<br />
Mr J Roberts<br />
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Mr & Mrs A & J Robertson<br />
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Mrs Ann Robertson<br />
Mr Hunter Robertson<br />
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Mr Matt Rowe<br />
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Miss Pat Sadler<br />
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Professor A G L Shaw AO<br />
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Further Information<br />
<strong>Annual</strong> <strong>Report</strong> 2010<br />
Donor Enquires<br />
Individuals and organizations interested in financially supporting the <strong>Institute</strong>’s work, or needing to advise a change of<br />
address, should contact the Development & Communications Manager on (03) 9388 1633.<br />
<strong>Institute</strong> Publications<br />
The annual report is the main source of information for our supporters. Supplementing this publication is a free bi-annual<br />
newsletter which outlines recent developments at the <strong>Institute</strong>.<br />
Contact the Development Officer on (03) 9388 1633 for placement on the Towards Understanding or annual report mailing<br />
lists, or simply to notify a change of address.<br />
Volunteers To Assist With <strong>Research</strong> Trials<br />
The <strong>Institute</strong> is always looking for people to assist us with our research. This assistance can take a number of courses.<br />
For example, sometimes we have new drugs to trial for Alzheimer’s disease, or we may want to compare responses in a<br />
group of people without mental illness with those who have a mental illness.<br />
Please call the <strong>Institute</strong> on (03) 9388 1633 if you would like to be directly involved in our research.<br />
Bequests<br />
The <strong>Institute</strong> has been able to continue its research and add strength to its work thanks to the people who have<br />
remembered the organisation’s work in their will. For further information about how to make a bequest to The <strong>Mental</strong> <strong>Health</strong><br />
<strong>Research</strong> <strong>Institute</strong>, please contact the Bequest Officer on (03) 9388 1633.<br />
Why Make A Will<br />
Making a Will ensures that your estate is distributed according to your wishes. After considering the needs of your family and<br />
friends, do think about making a gift in your Will to our research. Your gift, no matter what the amount, will help support our<br />
efforts to find better treatments for Alzheimer’s disease, schizophrenia and depressive illnesses. We strongly recommend you<br />
seek the professional advice of a solicitor when making your Will. However, a general guideline for wording is as follows:<br />
I Give Devise And Bequeath to the <strong>Mental</strong> <strong>Health</strong> <strong>Research</strong> <strong>Institute</strong> Incorporated of 155 Oak Street, Parkville, free of all<br />
duties the sum of……………. (or details of real property, shares or other assets) to be applied by it for its general purposes and<br />
I direct that the receipt of its Treasurer or other proper officer shall be full and sufficient discharge to my Executors.<br />
111
<strong>Mental</strong> <strong>Health</strong><br />
<strong>Research</strong> <strong>Institute</strong><br />
ABN: 48 101 228 451<br />
155 Oak Street, Parkville Victoria 3052<br />
Locked Bag 11, Parkville Victoria 3052<br />
P: +61 3 9388 1633 F: +61 3 9387 5061<br />
www.mhri.edu.au