Bavarian Biotech Report 2011/2012 (7MB) - Bio M

XL-protein GmbHBIOTECHKeywords: Peptide/Protein, Pharmacokinetics, Drug DevelopmentXL-protein is a biopharmaceutical company utilizing its proprietary‘PASylation’ technology to develop second generation biopharmaceuticalswith prolonged plasma half-life. PASylation of therapeutic proteins allowsless frequent and lower dosing combined with better tolerability, also openingperspectives for follow-on products of approved biopharmaceuticals.‘PASylation’ – the genetic fusion with conformationally disordered polypeptidesequences composed of the amino acids Pro, Ala, and Ser – provides asuperior way to attach a solvated random chain with large hydrodynamicvolume to a biologically active protein. Thus, its typically rapid clearance viakidney filtration can be retarded by one to two orders of magnitude whilethe PAS moiety is biochemically inert and easily degradable.Contact:Prof. Dr. Arne SkerraLise-Meitner-Str. 30D-85354 FreisingPhone: +49 (0) 8161 53730-90Fax: +49 (0) 8161 53730-99E-Mail: info@xl-protein.comInternet: www.xl-protein.comXvir Therapeutics GmbHBIOTECH THERAPEUTICS & DIAGNOSTICSXvir Therapeutics GmbH was founded in 2004 and is focusing on the clinicaldevelopment of novel cancer therapies for the treatment of various solidtumors, and in particular of drug-resistant or radiation-resistant tumors.Such cancer therapies are based on the use of oncolytic adenoviruses restoringdrug sensitivity and radiation-sensitivity, respectively, of the tumors.Experimental evidence for the efficacy of Xvir’s therapeutic approach hasbeen provided in several animal studies. Xvir’s therapeutic approach iscovered by proprietary patents and patent applications, respectively.Contact:Dr. Per Sonne HolmNymphenburger Str. 1D-80335 MünchenPhone: +49 (0) 89 99317446Fax: +49 (0) 89 51556413E-Mail: info@xvir.comInternet: www.xvir.comZentrum für Humangenetik undLaboratoriumsmedizin Dr. Klein undDr. Rost GbRBIOTECH THERAPEUTICS & DIAGNOSTICSKeywords: ELISA / EIA, Chip / Array Technology, Genomics, Microscopy, PCR,Pharmacogenomics, PharmacogeneticsThe Center for Human Genetics und Laboratory Medicine Dr. Klein and Dr.Rost in Martinsried was founded in 1998 and is accredited according to DINEN ISO/IEC 17025 and ISO 15189. The facility provides quality genetic servicesin diagnostics, prevention and management of hereditary disorders aswell as birth defects affecting the fetus, the newborn, the child and adults.The laboratory provides DNA/RNA testing for more than 200 diseases, continuouslydeveloping new tests and implementing state-of-the-art technologiessuch as array-CGH and Next Generation Sequencing (NGS).Contact:Dr. Hanns-Georg KleinLochhamer Str. 29D-82152 MartinsriedPhone: +49 (0) 89 895578-0Fax: +49 (0) 89 895578-780E-Mail: info@medizinische-genetik.deInternet: www.medizinische-genetik.de121