Patterned and switchable surfaces for biomaterial applications
Patterned and switchable surfaces for biomaterial applications
Patterned and switchable surfaces for biomaterial applications
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Andrew Hook – <strong>Patterned</strong> <strong>and</strong> <strong>switchable</strong> <strong>surfaces</strong> <strong>for</strong> <strong>biomaterial</strong> <strong>applications</strong>ACKNOWLEDGEMENTSAny large undertaking simply cannot be completed without the assistance of manydifferent people, which is particularly true <strong>for</strong> this PhD thesis. Firstly, I would like to extenda very big thanks to my two supervisors who have become my biggest scientific influences.Professor Nicolas Voelcker <strong>and</strong> Dr. Helmut Thissen, thank you both so very much <strong>for</strong> yourkind support, advice, time, encouragement, patience <strong>and</strong> wisdom that your have continuallyextended throughout my postgraduate study. I have greatly appreciated the friendship wehave been able to enjoy. Thank you <strong>for</strong> opening your scientific expertise <strong>and</strong> also yourhomes to me.The many colleagues I have shared ideas, laboratory space, skills <strong>and</strong> chemicals withhave all made important contributions to my PhD. Many thanks to Dr. Endre Szili. Youreally have taught me just about everything I know about cell culture. The skills you spentthe time to teach me right back at the start of Honours have been extremely important <strong>for</strong> theoverall success of my PhD. Thanks to Dr. Sue Low. Anything I didn’t learn about cellculture from Endre I learnt from you. Thank you <strong>for</strong> the time you gave to answer myquestions, give your advice <strong>and</strong> draw on the white board. We really did create somemasterpieces. Thank you also to Dr. Dusan Losic <strong>for</strong> your assistance with AFM.Thanks to Steve McInnes, Martin Cole <strong>and</strong> Matthew Nussio. Our friendship goes rightback to the start of uni. We are the first fledglings of the Nanotech phenomenon here atFlinders. Long may we continue to make the world a nano place. Thanks Steve <strong>for</strong> yourfriendship <strong>and</strong> all the squash games. I look <strong>for</strong>ward to many more, <strong>and</strong> maybe one day wewill beat Nico. Thank you Martin <strong>for</strong> your friendship, the surfing experience, touring Europewith me <strong>and</strong> <strong>for</strong> providing the PNIPAAm. I’m glad you taught me Aarhus is in Denmark.Thank you to Yamini Akkamsetty, Noni Creasy <strong>and</strong> Michael Olbrich <strong>for</strong> yourcontribution to this project.Thank you to Dr. Jamie Quinton <strong>and</strong> Dr. Joe Shapter <strong>for</strong> the use of your laboratory space,equipment <strong>and</strong> the corresponding support <strong>and</strong> advice here at Flinders. Your willingness tohelp has helped made things much easier <strong>and</strong> is greatly appreciated.Thank you to the many faces at CSIRO that have supported <strong>and</strong> befriended me when I’vevisited Melbourne. The welcome <strong>and</strong> advice you continually give makes working at CSIROso much more enjoyable <strong>and</strong> worthwhile. In particular, I would like to thank Dr. KeithMcLean, Dr. Thomas Gengenbach, Dr. Paul Pasic, Dr. Ben Muir <strong>and</strong> Dr. Anna Tarasova.Many thanks to Jason Hayes <strong>for</strong> time <strong>and</strong> assistance with laser ablation.Thank you to Krasimir Vasilev <strong>for</strong> your time, support <strong>and</strong> advice with SPR imaging.Thanks also to Tim Burl<strong>and</strong> from GWC technologies <strong>for</strong> your advice in regard to the trickyproblems encountered with the SPR imager.Thank you to Dr. B<strong>and</strong>aru Murthy <strong>for</strong> showing me India. Thank you to Associate Prof. N.Jayaraman <strong>and</strong> Prof. Dipankar Chatterji <strong>for</strong> your advice <strong>and</strong> laboratory space whilst in India.Thank you to Dr. Ken Short <strong>for</strong> your advice <strong>and</strong> assistance with <strong>for</strong>ce measurements.Thank you Dr. Daniel Jardine <strong>and</strong> Dominic Reppucci <strong>for</strong> your assistance with SPRmeasurements.Thank you to Flinders University, CSIRO, Australian Research Council <strong>and</strong> AustralianInstitute of Nuclear Science <strong>and</strong> Engineering <strong>for</strong> funding <strong>and</strong> the opportunity to conduct thisproject.Many, many thanks <strong>for</strong> the love <strong>and</strong> support of my family. Thank you to Auntie Trish <strong>and</strong>Uncle John <strong>for</strong> opening your home to my in Melbourne. To me beloved wife Cindy, I cannotimagine life without you. There are no words to express my gratitude.And finally, thank you to my Lord <strong>and</strong> Saviour Jesus Christ.VII