Patterned and switchable surfaces for biomaterial applications

Andrew Hook – Patterned and switchable surfaces for biomaterial applicationsOverexpressing a defined cDNA is useful for the genomic analysis of proteins ofinterest that are functioning within their natural environments. Receptor proteinshave been a focus of these studies and, in particular, the screening of activators andinhibitors of GPCRs [148]. As GPCRs are currently the target of 40% of commercialdrugs, determining the functionality and binding properties of unstudied GPCRs willlikely determine other potential drug targets. Furthermore, microarray analysis ofthese receptors in a microarray format enables the high-throughput examination ofthe selectivity of drugs and identification of any side-reactions.Recently, RNAi has been demonstrated on TCMs [150, 152-154]. RNAi formammalian cells involves the use of either short (