Patterned and switchable surfaces for biomaterial applications

Chapter 1 - IntroductionTable 1.1. Outline of the applications of transfected cell microarrays.ApplicationReferencesScreening of siRNAs and shRNAs for effective silencing of target genes by RNAi.Use of RNAi for gene function determination. [150-154]Development of a reporter system for monitoring the expression of proteinsassociated with signalling pathways. [155, 156]Assignment of the position of subcellular localised proteins. [147, 157]Automated analysis of nuclear area, cell area and number of cells. [158]Screening for agonists and antagonists of GPCRs. [148]Screening for gene products that are involved with kinase signalling pathways,stimulation of apoptosis or cell-cell adhesion. [8]Monitoring the interaction of receptor molecules with membrane-bound signalproteins. [8, 159]Use of linear polymerase chain reaction (PCR) products for TCM format. [155]1-48