Patterned and switchable surfaces for biomaterial applications

Andrew Hook – Patterned and switchable surfaces for biomaterial applications(A)(B)(C)(D)Figure 1.7. A patterned co-culture of hepatocytes and endothelial calls. (A) Thepatterned metal mask with holes (1-mm diameter) used for surfacepatterning of PNIPAAm and PS. (B) Hepatocytes were seeded and adheredhomogeneously on the whole surfaces at 37 °C. (C) By reducing thetemperature, hepatocytes detached spontaneously and selectively fromPNIPAAm -grafted domains. (D) Endothelial cells were seeded andcocultured with formerly seeded hepatocytes at 37 °C, forming a co-culture.Scale bars = (A, C, D) 1 mm and (B) 200 m. From [73].1-37