Patterned and switchable surfaces for biomaterial applications

Andrew Hook – Patterned and switchable surfaces for biomaterial applicationsrespectively (Table 5.1). These lower values are likely due to the lower molecularweight of the adsorbed BSA of 68 kDa [296] as compared with 407 kDa for CN typeI [297] and 450 kDa for FN [288]. Thus, the adsorption of a single BSA moleculewill produce only 15% of the equivalent response of a FN molecule. Furthermore, athicker layer would be expected for monolayer coverage of FN and CN type I ascompared with BSA due to the larger size of FN and CN type I. The A biomol of 30 and35 nm 2 for BSA adsorption to PEIc and PLLc (Table 5.2), respectively, suggests thatapproximately 54% and 62% of the protein area (total size is 56 nm 2 [298]) is incontact with the surface at complete coverage. BSA adsorption to PLL haspreviously been studied given a s of 6.5 mg/m 2 [295]. This higher BSA adsorptionis likely due to the lower pH of 5 at which the adsorption was conducted.5-201