Patterned and switchable surfaces for biomaterial applications

Andrew Hook – Patterned and switchable surfaces for biomaterial applicationslayer system of a glass prism (η = 1.71129), a 45 nm gold layer (η = 0.16 + 4.84i)[265, 266], a PLL polymer layer of varied thickness (η = 1.37) and an infinite waterlayer (η = 1.32908) [267]).and in Figure 5.5B as the change in reflectivity against theangle of incidence, it can be seen from Figure 5.5B that the angles at which each spotreaches the greatest absolute value for the differential of SPR reflectivity occurs overa range of 49.3° to 53.5°. 49.3° was selected for subsequent fixed angle theoreticalcalculations. For formation of a polymer microarray consisting of varied polymermaterials of different refractive index properties this problem is further amplified.Furthermore, each polymer spot formed by robotic spotting will have non-ideal,rough topography. It is, thus, difficult to select one single angle at which the SPRintensity will be of equivalent sensitive to changes in refractive index for all spots.5-175