Patterned and switchable surfaces for biomaterial applications

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Chapter 1 - Introductioninteractions of the DNA base pairs [18, 19], although hydrogen bond formation alsoplays a certain role in DNA surface interactions in aqueous conditions [20]. Unlikesynthetic polyelectrolytes, which generally adopt a loop-train conformation whenadsorbed to a surface due to their flexible ‘thread-like’ nature [21], double-strandedDNA (dsDNA) can be considered as a rigid rod (Figure 1.1B) with a nitrogenouscore and a phosphate and pentose sugar exterior (Figure 1.1A) such that it generallylies flat to a surface upon adsorption [22]. Conversely, although more ordered andrigid than synthetic polyelectrolytes, single-stranded DNA (ssDNA) can beconsidered as a flexible thread, not nearly as rigid as dsDNA, with the nitrogenousbases readily exposed (Figure 1.1C). Thus, hydrophobic interactions play a moresignificant role with the adsorption of ssDNA as compared with dsDNA [22].1-6
Andrew Hook – Patterned and switchable surfaces for biomaterial applications(A) (B) (C)NONGuanineN NnOOPOOOOBaseNNNNNAdenineN NNNNCytosineOONNThymineOFigure 1.1. Structure of DNA. (A) The chemical structure of DNA nucleotides, (B)three dimensional space filling model of B-type helical dsDNA, (C) threedimensional space filling model of ssDNA.1-7
Page 1 and 2: Patterned andswitchable surfacesfor
Page 3 and 4: TABLE OF CONTENTSTABLE OF CONTENTS
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Chapter 1 - IntroductionOnce releas
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Chapter 1 - Introductionimaging not
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Chapter 1 - IntroductionA number of
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CHAPTER 2.SPATIALLY CONTROLLED ELEC
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CHAPTER 3.COMPARISON OF THE BINDING
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DNA (mg/m 2 ) DNA (mg/m 2 )Andrew H
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DNA (mg/m 2 )Andrew Hook - Patterne
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Chapter 4 - Formation of a chemical
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CHAPTER 5.SURFACE PLASMON RESONANCE
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SPR signal intensity (counts)Andrew
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Reflectivity (%) Reflectivity (%)An
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SPR signal intensity (counts)Andrew
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Thickness (nm)Thickness (nm)Thickne
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CHAPTER 6.OVERALL CONCLUSIONS6.6An
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Chapter 6 - Overall conclusionsThes
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Chapter 6 - Overall conclusionsnew
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Force (nN)Force (nN)Force (nN)Force
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Patterned and switchable surfaces for biomaterial applications

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