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<strong>Column</strong>s for Special ApplicationsUltron ES Chiral <strong>Column</strong>s• Direct racemic separations without derivatization• Use Ultron ES-OVM as the USP L57 choice and to separate enantiomers of acidicand basic pharmaceuticals, such as hexobarbital, ibuprofen, and profenamine• Ultron ES-Pepsin Chiral columns are best suited to separate basic compounds thatare difficult to separate with other chiral columns• ES-OVM and ES-Pepsin columns contain 120Å, 5 µm silica particles bonded with anovomucoid protein and pepsin protein, respectively• Both types of chiral columns are usable with reversed-phase mobile phases such asacetonitrile or ethanol and phosphate bufferUltron ES Chiral columns are immobilized protein columns that feature numerous chiralrecognition sites for enantiomeric separations of dozens of chiral compounds. They areengineered with two complementary protein-based chiral stationary phases, making theman excellent choice for the <strong>HPLC</strong> separation of enantiomers without derivatization – includinga growing number of drug substances of interest.Separation of Enantiomers of Fluoxetine (Prozac)<strong>Column</strong>: Ultron ES-OVM Chiral7021116514.6 x 150 mm, 5 µmMobile Phase: 25:75 (v/v) EtOH / 20 mM KH 2 PO 4 , pH 5.5(adjusted with NaOH)Temperature: AmbientDetector: UV (225 nm)Sample: Mixture Fluoxetine (Prozac) entantiomersCourtesy of D. S. Risley and V. S. Sharp of Lilly Research Laboratories, Eli Lilly and Co.0 510 15Retention Time (min)20 25 30LCUC001Order online at www.agilent.com/chem/store103
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