Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ...
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patrick-poulin@videotron.ca P. Poulin. April, 2007.<strong>Distribution</strong> <strong>Prediction</strong> AAPS – November 11, 2009<strong>Distribution</strong> Parameters EstimationMETHOD XMETHOD YKpEssential inputParameters <strong>of</strong>PBPK modelsTissue<strong>Volume</strong>sVdssVdssVdss = volume <strong>of</strong> distribution at steady-stateKp = tissue:plasma (blood) ratios at steady-state