Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ...
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patrick-poulin@videotron.ca P. Poulin. April, 2007.<strong>Distribution</strong> <strong>Prediction</strong> AAPS – November 11, 2009<strong>Distribution</strong><strong>Distribution</strong>The distribution <strong>of</strong> xenobiotics inthe body after their absorptionExtent <strong>of</strong> <strong>Distribution</strong>Determined by:• partitioning across various membranes.• non-specific binding to tissue components.• specific binding to proteins.• physiological volumes.
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