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patrick-poulin@videotron.ca P. Poulin. April, 2007.Distribution Prediction AAPS – November 11, 2009AAPS6. AcknowledgementsNamesInstitutionsDr. Zhang Hua LillianDr. Jennifer ShengDr. Michael HagemanPhRMA membersProf. Kannan KrishnanThomas PeyretProf. Sami HaddadFDA, Washington DCAstrazeneca, USABMS, USAPhRMA, Washington DCUniversité de MontréalUniversité de MontréalUQAM, MontréalDr. Thierry LavéHoffmann-La Roche, BaselDr. Frank-P Theil Genentech, San FranciscoThank you!
ReferencesPoulin P, Theil FP. 2002. Prediction of pharmacokinetics prior to in vivo studies: 1. Mechanism-based prediction ofvolume of distribution. J Pharm Sci 91:129-156.Poulin P, Theil FP. 2009A. Development of a novel method for predicting volume of distribution at steady-state ofbasic drugs and comparative assessment with existing methods. J Pharm Sci 98:4941-4961.Poulin P, Theil FP. 2009B. Follow up of a novel correlation method used to predict volume of distribution atsteady-state. J Pharm Sci (October, submitted).Berezhkovskiy LM. 2004. Volume of distribution at steady-state for a linear pharmacokinetic system withperipheral elimination. J Pharm Sci 93:1628-1640.Rodgers T, Leahy D, Rowland M. 2005. Physiologically based pharmacokinetic modeling 1: Predicting the tissuedistribution of moderate-to-strong bases. J Pharm Sci 94:1259-1267.Rodgers T, Rowland M. 2007. Mechanistic approaches to volume of distribution predictions: Understanding theprocesses. Pharm Res 24:918-933.Lombardo F. 2004. Prediction of volume of distribution values in human for neutral and basic drugs usingphysicochemcal measurements and plasma protein binding data. J Med Chem 47:1243-1250.Jansson R, Bredberg U, Ashton M. 2008. Prediction of drug tissue to plasma concentration ratios using ameasured volume of distribution in combination with lipophilicity. J Pharm Sci 97:2324-2339.Bjorkman S. 2002. Prediction of the volume of distribution of a drug: which tissue-plasma partition coefficients areneeded? J Pharm Pharmacol 54: 237-245.GastroPlus®. www.simulationplus.com. Lancaster California.Lowe HJ and Hagler K. 1969. Determination of volatile organic anesthetics in blood, gases, tissues and lipids:partition coefficients. In: Porter R, ed. Gas chromatography in biology and medicine. A Ciba-GeigyFoundation Symposium. Chruchill, New York. Pp. 86-103.Arundel PA. 1997. A multi-compartmental model generally applicable to physiologically-based pharmacokinetics.(Astra-Zeneca, UK). Poster presentation during the third IFAC symposium. Modeling and control inbiomathematical systems. University of Warwick, UK, 23–26 March.Paterson S, and Mackay D. 1989. Correlation of tissue, blood and air partition coefficients of volatile organicchemicals. Brit. J. Ind. Med. 46: 321-328.
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