Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
patrick-poulin@videotron.ca P. Poulin. April, 2007.<strong>Distribution</strong> <strong>Prediction</strong> AAPS – November 11, 2009Comparison <strong>of</strong> <strong>Prediction</strong> Methods <strong>of</strong> <strong>Distribution</strong>Peyret T, Poulin P, Krishnan K. Toxicological Sciences (2010)MECHANISTICEQUATIONSENVIRONMENTAL CHEMICAL PCsPHARMACEUTICAL PCsTISSUE:AIR BLOOD:AIR BLOOD:AIR TISSUE:BLOOD TISSUE:PLASMA UNBOUNDALL VOCsLIPOPHILICVOCsHYDROPHILICVOCsPoulin & Krishnan (1996) A X X X XCONTAMINANTS BASES ACIDS, NEUTRALS,ZWITERRIONSHaddad et al. (2000) BXPoulin & Theil (2002) C X X XRodgers et al. (2005) DXRodgers & Rowland (2006) EXSchmitt (2008) F X XSUGGESTED UNIFIEDALGORITHMX X X X X XA: Toxicol Appl Pharmacol 136: 126-130 and 131-137.B: Chemosphere 40: 839-843..C: J Pharm Sci 91:129-156.D: Pharm Res 24:918-933.E: J Pharm Sci 95:1238-1249.F: Toxicol In Vitro 22: 457-67