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patrick-poulin@videotron.ca P. Poulin. April, 2007.Distribution Prediction AAPS – November 11, 2009PHYSIOLOGY VS ALLOMETRYHuman Vdss% Within 2-FoldError Window100%PHYSIOLOGICALIN VITRO-BASED94%25 DRUGS OUF OF THOSE THREE DATASETSIN VIVO-BASED85%COMMON EMPIRICAL75%ALLOMETRY(SA BOUND & UNBOUND DRUGS)*65%50%30%33%*Rat, dog + mouse and/or monkey0%
patrick-poulin@videotron.ca P. Poulin. April, 2007.Distribution Prediction AAPS – November 11, 2009AAPS4. Further Developments
Page 1 and 2: AAPSVolume of Distribution Predicti
Page 3 and 4: patrick-poulin@videotron.ca P. Poul
Page 19 and 20: Additional Validation of this Study
Page 21 and 22: % WITHIN 2-FOLD ERRORPredictive Per
Page 23: % WITHIN 2-FOLD ERRORpatrick-poulin
Page 29 and 30: Cell permeability (cm/s)Cell permea
Page 33: ReferencesPoulin P, Theil FP. 2002.

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