Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ...
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patrick-poulin@videotron.ca P. Poulin. April, 2007.<strong>Distribution</strong> <strong>Prediction</strong> AAPS – November 11, 2009PHYSIOLOGY VS ALLOMETRYHuman Vdss% Within 2-FoldError Window100%PHYSIOLOGICALIN VITRO-BASED94%25 DRUGS OUF OF THOSE THREE DATASETSIN VIVO-BASED85%COMMON EMPIRICAL75%ALLOMETRY(SA BOUND & UNBOUND DRUGS)*65%50%30%33%*Rat, dog + mouse and/or monkey0%