Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ... Volume of Distribution Prediction: Physiologically Based ...
patrick-poulin@videotron.ca P. Poulin. April, 2007.Distribution Prediction AAPS – November 11, 2009Predictive Performance in HumanIn vitro models - Dataset on Vdss of 61 Basic drugsHuman VdssPERCENTAGE WITHIN 2 FOLD-ERRORHybrid (Poulin)10080Oie-Tozer (Lombardo)6040200TC1 (Poulin)TC4 (GastroPlus)TC2 (Berezhkovskiy)TC3 (Rodgers)Poulin and Theil, 2009AB, JPS(A:accepted, B:submitted)
% WITHIN 2-FOLD ERRORpatrick-poulin@videotron.ca P. Poulin. April, 2007.Distribution Prediction AAPS – November 11, 2009Predictive Performance in RatIn vitro & In vivo models - Dataset on rat Kp’s of 64 drugsChoosing the more accurate method for each class of drugsRat Kp’s (13 tissues) (n=600)1007550TC1 (Poulin)TC3 (Rodgers)TC4 (GastroPlus)Correlation (Janssen)250Neutrals Acids Bases Zwiterions
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patrick-poulin@videotron.ca P. Poulin. April, 2007.<strong>Distribution</strong> <strong>Prediction</strong> AAPS – November 11, 2009Predictive Performance in HumanIn vitro models - Dataset on Vdss <strong>of</strong> 61 Basic drugsHuman VdssPERCENTAGE WITHIN 2 FOLD-ERRORHybrid (Poulin)10080Oie-Tozer (Lombardo)6040200TC1 (Poulin)TC4 (GastroPlus)TC2 (Berezhkovskiy)TC3 (Rodgers)Poulin and Theil, 2009AB, JPS(A:accepted, B:submitted)
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