Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ...
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% WITHIN 2-FOLD ERRORPredictive Performance in HumanIn vitro & In vivo models - Dataset on Vdss <strong>of</strong> 39 drugsHuman Vdss100STRONG ACIDS ALL & NEUTRALS DRUGS BASES (n=39) (n=16) (n=23)755025 250TC1 (Poulin)TC1 (Poulin)TC3 (Rodgers)TC3 (Rodgers)TC4 (GastroPlus)TC1 (Poulin, 2002)TC2 (Berezhkovskiy)TC3 (Rodgers)TC2 (Berezhkovskiy)TC2 (Berezhkovskiy)Oie-Tozer (Lombardo)TC4 (GastroPlus)Correlation (Janssen)Arundel (AZ)Correlation (Janssen)Arundel (AZ)Correlation (Janssen)Arundel (AZ)TC4 (GastroPlus)Hybrid (Poulin, 2009)