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patrick-poulin@videotron.ca P. Poulin. April, 2007.Distribution Prediction AAPS – November 11, 2009Reported Predictive Performance for Kp and Vdssusing diverse Datasets and Methods% Within 2-FoldError Window100%Rat Kp’s*81%Rat Vdss85%Human Vdss94%50%39%35%14%0%* : 13 tissues
% WITHIN 2-FOLD ERRORPredictive Performance in HumanIn vitro & In vivo models - Dataset on Vdss of 39 drugsHuman Vdss100STRONG ACIDS ALL & NEUTRALS DRUGS BASES (n=39) (n=16) (n=23)755025 250TC1 (Poulin)TC1 (Poulin)TC3 (Rodgers)TC3 (Rodgers)TC4 (GastroPlus)TC1 (Poulin, 2002)TC2 (Berezhkovskiy)TC3 (Rodgers)TC2 (Berezhkovskiy)TC2 (Berezhkovskiy)Oie-Tozer (Lombardo)TC4 (GastroPlus)Correlation (Janssen)Arundel (AZ)Correlation (Janssen)Arundel (AZ)Correlation (Janssen)Arundel (AZ)TC4 (GastroPlus)Hybrid (Poulin, 2009)
Page 1 and 2: AAPSVolume of Distribution Predicti
Page 3 and 4: patrick-poulin@videotron.ca P. Poul
Page 19: Additional Validation of this Study
Page 23 and 24: % WITHIN 2-FOLD ERRORpatrick-poulin
Page 29 and 30: Cell permeability (cm/s)Cell permea
Page 33: ReferencesPoulin P, Theil FP. 2002.

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