Volume of Distribution Prediction: Physiologically Based ...
Volume of Distribution Prediction: Physiologically Based ... Volume of Distribution Prediction: Physiologically Based ...
patrick-poulin@videotron.ca P. Poulin. April, 2007.Distribution Prediction AAPS – November 11, 2009Predicting Distribution for DrugsNeutral VOCsBasesacidic phospholipids,cation transportersAcids, Neutralsalbumin, lipoproteinsIonizationPlasma proteinsbindingDrugs
patrick-poulin@videotron.ca P. Poulin. April, 2007.Distribution Prediction AAPS – November 11, 2009Existing Prediction methods of Kpand/or Vdss based on PhysiologyTissue compositionmodels/algorithmsAll in vitro-basedLowe and HaglerPaterson and MackayPoulin et alBerezhkovskiyRodgers & RowlandGastroPlus®Correlation-HybridmodelsPoulin & Theil (in vitro-based)Bjorkman (in vivo-based)Janssen et al (in vivo-based)Arundel modelAstra Zeneca (in vivo-based)Oie-Tozer modelLombardo et al (in vitro-based)
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- Page 33: ReferencesPoulin P, Theil FP. 2002.
patrick-poulin@videotron.ca P. Poulin. April, 2007.<strong>Distribution</strong> <strong>Prediction</strong> AAPS – November 11, 2009Predicting <strong>Distribution</strong> for DrugsNeutral VOCsBasesacidic phospholipids,cation transportersAcids, Neutralsalbumin, lipoproteinsIonizationPlasma proteinsbindingDrugs
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