Volume of Distribution Prediction: Physiologically Based ...

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patrick-poulin@videotron.ca P. Poulin. April, 2007.Distribution Prediction AAPS – November 11, 2009Starting Point of Tissue CompositionModels (TC) – Reconstituting the tissueExperimental work of Lowe & Hagler, 1969 for VOCs:Triglyceride:air PCTissuecomponentsCholesterol:air PCPhospholipid:air PCWater:air PCKp ( tissue:air)PC : air * VcComponentvolume fractions
patrick-poulin@videotron.ca P. Poulin. April, 2007.Distribution Prediction AAPS – November 11, 2009In-vitro Distribution of Neutral VOCsSupporting the Concept of Lowe & HaglerPoulin and Krishnan & de Jongh et al.
Page 1 and 2: AAPSVolume of Distribution Predicti
Page 3 and 4: patrick-poulin@videotron.ca P. Poul
Page 9: patrick-poulin@videotron.ca P. Poul
Page 19 and 20: Additional Validation of this Study
Page 21 and 22: % WITHIN 2-FOLD ERRORPredictive Per
Page 23 and 24: % WITHIN 2-FOLD ERRORpatrick-poulin
Page 29 and 30: Cell permeability (cm/s)Cell permea
Page 33: ReferencesPoulin P, Theil FP. 2002.

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