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ResH&S 2012 FINAL

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RESPIRATORY HEALTH AND SAFETY IN THE FLAVOR MANUFACTURING WORKPLACEKovacic P. and Cooksy A.L. Electron transfer asa potential cause of diacetyl toxicity in popcornlung disease. Rev. Environ. Contam. Toxicol.,204,133. 2010.Maier A., Kohrman-Vincent M., Parker A., andHaber L. Evaluation of concentration-responseoptions for diacetyl in support of occupationalrisk assessment. Regulatory Toxicology & Pharmacology.58, 285. 2010.Mathews J. M., Burgess J. P., Snyder R. W.,Etheridge A. S., Burka L. T. Reaction of the butterflavorant butanedione with N-R-acetylarginine.Drug Metab. Rev., 37, 273. 2005.Mathews J.M., Watson S.C., Snyder R.W., BurgessJ.P. and Morgan D.L. Reaction of the butterflavorant diacetyl (2,3-butanedione) withN-r-acetylarginine: A model for epitope formationwith pulmonary proteins in the etiology ofobliterative bronchiolitis. J. Agric. Food Chem.,58,12761. 2010.Morgan D.L., Flake G.P., Kirby P.J. and PalmerS.M. Respiratory toxicity of diacetyl in C57B1/6mice. Toxicol. Sci., 103(1): 169-180. 2008.Gloede E., Cichoki J.A., Baldino J.B. and MorrisJ.B. A validated hybrid computational fluiddynamics-physiologically based pharmacokineticmodel for respiratory tract vapor absorptionin the human and rat and its application toinhalation dosimetry of diacetyl. ToxicologicalSciences. Advanced access. 24 June 2011.VanRooy F.G.B.G.J., Rooyackers J.M., ProkopM., Houba R., Smit A.M. and Heederik D.J.J.Bronchiolitis obliterans syndrome in chemicalworkers producing diacetyl for food flavorings.Am. J. Respir. Crit. Care Med., 176(5): 498-504.2007.VanRooy F.G.B.G.J., Smit L.A.M., Houba R.,Zaat V.A.C., Rooyackers J.M. and HeederikD.J.J. A cross sectional study on lung functionand respiratory symptoms among chemicalworkers producing diacetyl for food flavourings.Occup Environ Med, 66,105. 2009.Zviely M. Molecule of the month: 2,3-pentanedione.Perfumer & Flavorist. 34(7), 20.2009.Morgan D.L., Kirby P.J., Price H.C., BousquetR.W., Taylor G.J., Gage N. and Flake G.P. Inhalationtoxicity of acetyl propionyl in rats andmice. The Toxicologist, 114, 316. 2010.Morris J.B. and Hubbs A.F. Inhalation dosimetryof diacetyl and butyric acid, two componentsof butter flavoring vapors. Toxicol. Sci. 108(1):173. 2009.14

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