Nucleic Acids as Therapeutic Agents - icaam

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Fig. 11.8 Two-dimensional representation of A hammerhead and B hairpinribozyme-mRNA substrate complexes. Naturally-occurring catalytic RNA ~40-50 nucleotides long. Introduced by transfection of ds DNA version on a vector.The mRNA substrates and ribozymes are shown in red and blue, respectively.Abbreviations: Y, a pyrimidine nucleotide (C or U); R, a purine nucleotide (A orG); H, any nucleotide except G; B, any nucleotide except A; V, any nucleotideexcept U; N and N’, any complementary nucleotides. An arrow indicates thepoint of mRNA cleavage.AB
Thom<strong>as</strong> Cech and Sidney Altman shared the 1989Nobel Prize in chemistry for discovering the catalyticproperties of RNA
Page 1 and 2: Nucleic Acids asTherapeutic Agents
Page 3 and 4: Fig. 11.1 Inhibition of translation
Page 5: Fig. 11.7 Schematic representation
Page 9 and 10: Vascular endothelialgrowth factor
Page 11 and 12: Interfering RNAs• Addition of ds
Page 13 and 14: Fire and Mello shared the 2006 Nobe
Page 15 and 16: Nucleic Acid Delivery
Page 17 and 18: Gene Doping: non-therapeutic use of
Page 19 and 20: Fig. 11.21 Use of a nonpathogenic s
Page 21 and 22: Fig. 11.23 A single chain Fab fragm

Nucleic Acids as Therapeutic Agents - icaam

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