Nucleic Acids as Therapeutic Agents - icaam

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Fig. 11.22 Negatively charged siRNAs bind to positively chargedatelocollagen (subunit size ~300 kDa; from calf dermis followingdigestion with pepsin in acid). The complex facilitates delivery ofsiRNAs and protects them against nuclease digestion. Used to deliversiRNA to injected mice.
Fig. 11.23 A single chain Fab fragment directed against a mammaliancell surface (breast cancer) protein is fused to the positively chargedpolypeptide protamine which binds non-covalently to negativelycharged siRNAs. The Fab fragment acts to deliver the siRNA tospecific cancerous cells. A two chain Fab fragment has also beenused to deliver siRNAs. Used in culture and by injecting directly intotumours.
Page 1 and 2: Nucleic Acids asTherapeutic Agents
Page 3 and 4: Fig. 11.1 Inhibition of translation
Page 5 and 6: Fig. 11.7 Schematic representation
Page 7 and 8: Thomas Cech and Sidney Altman share
Page 9 and 10: Vascular endothelialgrowth factor
Page 11 and 12: Interfering RNAs• Addition of ds
Page 13 and 14: Fire and Mello shared the 2006 Nobe
Page 15 and 16: Nucleic Acid Delivery
Page 17 and 18: Gene Doping: non-therapeutic use of
Page 19: Fig. 11.21 Use of a nonpathogenic s

Nucleic Acids as Therapeutic Agents - icaam

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