Nucleic Acids as Therapeutic Agents - icaam
Nucleic Acids as Therapeutic Agents - icaam Nucleic Acids as Therapeutic Agents - icaam
Fig. 11.13 Overview of the process of RNA interference. Followingintroduction of double stranded (ds) RNA into a cell, the Dicer complexbinds to the RNA and cleaves it to a siRNA containing approximately 21-bp.The antisense strand (red) becomes part of the RISC complex, directing thecleavage of the complementary mRNA. A short hairpin RNA encoded on aplasmid may be used intead of ds RNA.
Fire and Mello shared the 2006 Nobel Prize fordiscovering RNA interferenceAndrew FireCraig Mello
- Page 1 and 2: Nucleic Acids asTherapeutic Agents
- Page 3 and 4: Fig. 11.1 Inhibition of translation
- Page 5 and 6: Fig. 11.7 Schematic representation
- Page 7 and 8: Thomas Cech and Sidney Altman share
- Page 9 and 10: Vascular endothelialgrowth factor
- Page 11: Interfering RNAs• Addition of ds
- Page 15 and 16: Nucleic Acid Delivery
- Page 17 and 18: Gene Doping: non-therapeutic use of
- Page 19 and 20: Fig. 11.21 Use of a nonpathogenic s
- Page 21 and 22: Fig. 11.23 A single chain Fab fragm
Fig. 11.13 Overview of the process of RNA interference. Followingintroduction of double stranded (ds) RNA into a cell, the Dicer complexbinds to the RNA and cleaves it to a siRNA containing approximately 21-bp.The antisense strand (red) becomes part of the RISC complex, directing thecleavage of the complementary mRNA. A short hairpin RNA encoded on apl<strong>as</strong>mid may be used intead of ds RNA.
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