Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
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<strong>14C</strong> SynthesisOHOMOMOMOMNaH/DMFn-BuLiI* * *MOM-ClI 2[ 14 C]-1Step 1 [ 14 C]-2 Step 2 [ 14 C]-3CuBr/DMFNaOMe/MeOHOMOMO OMOMOMe n-BuLiOMeH* *DMFStep 3 [ 14 C]-4 Step 4[ 14 C]-5O OHHCl/MeOH ICl / CHOMe2 Cl 2H*NaHCO 3HOOH*ClOMe* = U- 14 CStep 5[ 14 C]-6Step 6[ 14 C]-7
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