Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
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[ 14 C]ZT-1: a new generation <strong>of</strong> acetylcholinesterase(AChE) inhibitorsL Leman, S L Kitson et al. J. Label Compd. Radiopharm 2011, 720-730CH 3exocyclic E-double bondbicyclo[3.3.1] double bondHNOH 3CCH 3NH 2hydrogen bondHOMeOCH 3N RHNHOactive metabolite, (-)-huperzine Ain vivoprogressive hydrolysis+CHOOHClpyridin-2-one ringClOMePro-drug (-)ZT-1inactive metabolite, 5-chloro-o-vanillin
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