Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
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<strong>14C</strong> <strong>Synthetic</strong> routeR T Brown et al. J Label Compd. Radiopharm 2009, 52, 567-570MeOO<strong>14C</strong>H 3ITBAFCH 3CNMeOOTBSOO75%<strong>14C</strong>H 3OOOMeOMeOMeOMeTiCl 4/ DCMMeOOH(BnO) 2P(O)H27%<strong>14C</strong>H 3OOHCCl 4/ CH 3CNOMeOMeDIPEA / DMAP72%MeOOP(O)(OBn) 21. TMSBr / MeCN2. KOMe, MeOH3. HCl/H 2O/EtOHMeOOPOOHO<strong>14C</strong>H 3OOMeOMeOP(O)(OBn) 257%<strong>14C</strong>H 3OOMeOMeOOP.2K +OOH[methyl- 14 C]-Combretastatin A1 diphosphate