Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
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Target: [methyl- 14 C]Combretastatin A-1 diphosphateMeO<strong>14C</strong>H 3OOMe• Treatment <strong>of</strong> solid tumoursOMeO• The pro-drug undergoes in vivo de-phosphorylationto generate the active agent combretastatin A-1OPOOPOHO.2K +OOH