Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
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Chiral SeparationMeO*N CH3HMeO(R/S)-(+/-)-[6a- 14 C]Apomorphine dimethyl etherHPLC Conditions: Chiralcel OD column, eluting withhexane/propan-2-ol/dimethylamine [950:50:5]MeO*N CH3HSMeO*N CH3HRMeOMeO(S)-(+)-[6a- 14 C]Apomorphine dimethyl etherRadiochemical yield = 11% fromTetrahydro[ 14 C]isoquinoline(R)-(-)-[6a- 14 C]Apomorphine dimethyl etherRadiochemical yield = 16% fromTetrahydro[ 14 C]isoquinoline