Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
Synthetic Strategies for 14C Labelling of Drug Molecules Dr ... - Almac
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Synthesis <strong>of</strong> N-[carboxyl- 14 C]acetamideK 14 CN55mCi/mmolNO 2MeODMeO(COCl) 2DMFMeOMeOClNO 2D*OClMeOMeOANO 290% 86%86%(2 steps)NOacid2* hydrolysis MeOCN*OMeONONH 2H2 MeO* NDOMeOOHN-[carboxyl- 14 C]AcetamideARadiochemical yield = 67%